CN113030480B - Reagent preheating device and sample analyzer - Google Patents
Reagent preheating device and sample analyzer Download PDFInfo
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- CN113030480B CN113030480B CN201911359193.9A CN201911359193A CN113030480B CN 113030480 B CN113030480 B CN 113030480B CN 201911359193 A CN201911359193 A CN 201911359193A CN 113030480 B CN113030480 B CN 113030480B
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G01N2333/4737—C-reactive protein
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Abstract
The embodiment of the application discloses a reagent preheating device and a sample analyzer, wherein the reagent preheating device comprises a first pipeline assembly and a second pipeline assembly, the first pipeline assembly comprises a first preheating matrix and a first pipeline for conveying a first reagent, and the first preheating matrix is used for preheating the first reagent; the second pipeline assembly comprises a second preheating matrix and a second pipeline for conveying a second reagent, one end of the second pipeline is connected with the first pipeline, the second preheating matrix is used for preheating the second reagent, and the second pipeline is used for conveying the second reagent to the reaction tank through the first pipeline under the action of a pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to a reaction tank together with the first reagent in the first pipeline; the diameter of the second pipe is larger than the diameter of the first pipe so that the preheating speed of the first reagent is larger than the preheating speed of the second reagent.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a reagent preheating device and a sample analyzer.
Background
When a sample is tested, as the antigen-antibody reaction binding speed in the CRP reaction process is greatly affected by temperature, the temperature is higher, the reaction rate is increased, and the obtained CRP value is higher than the true value; and if the temperature is lower, the reaction rate is reduced, and the obtained CRP value is lower than the true value, so that the CRP value obtained by the detection system is larger in difference, and the consistency and accuracy of the measurement result are affected.
The CRP measurement system used at present cannot preheat two or three reagents together, and multiple reagents are required to be mixed after being preheated separately, so that the CRP measurement system is complex in structural design and high in manufacturing and maintaining cost.
Disclosure of Invention
The application provides a reagent preheating device and sample analyzer can preheat two kinds of reagents simultaneously through first pipeline and first pipeline, not only simple structure, the cost of manufacture is low moreover.
According to a first aspect of the present application, there is provided a reagent preheating apparatus comprising:
a first conduit assembly comprising a first preheating substrate and a first conduit for transporting a first reagent, the first preheating substrate being for preheating the first reagent;
the second pipeline assembly comprises a second preheating matrix and a second pipeline for conveying a second reagent, one end of the second pipeline is connected with the first pipeline, the second preheating matrix is used for preheating the second reagent, and the second pipeline is used for conveying the second reagent to the reaction tank through the first pipeline under the action of a pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to a reaction tank together with the first reagent in the first pipeline;
Wherein the diameter of the second pipeline is larger than the diameter of the first pipeline, so that the preheating speed of the first reagent is larger than the preheating speed of the second reagent.
In the preheating device of the present application, the first pipeline is spiral and wound on the first preheating substrate, and/or the second pipeline is spiral and wound on the second preheating substrate.
In the preheating device of the application, a first substrate spiral groove is formed in the first preheating substrate, the diameter of the first substrate spiral groove is matched with the diameter of the first pipeline, and the first pipeline is wound on the first substrate spiral groove.
In the preheating device of the application, a second substrate spiral groove is formed in the second preheating substrate, the diameter of the second substrate spiral groove is matched with the diameter of the second pipeline, and the second pipeline is wound on the second substrate spiral groove.
In the preheating device of the application, the outside of the first pipeline and the second pipeline are both coated with heat preservation cotton, and the heat preservation cotton is used for preserving heat of the first reagent in the first pipeline and the second reagent in the second pipeline.
In the preheating device, the first preheating substrate is arranged at the upper end of the second preheating substrate, and the diameter of the first preheating substrate is equal to that of the second preheating substrate.
In the preheating device of the application, the preheating device comprises a heat storage substrate and a heating source, wherein a substrate installation part is arranged on the heat storage substrate, the lower end of the second preheating substrate is installed on the substrate installation part, and the heating source is used for heating the heat storage substrate.
In the preheating device of the application, the preheating device comprises a locking piece, a base body installation part is provided with a fixed through hole, a first base body through hole is formed in a first preheating base body, a second base body through hole is formed in a second preheating base body, and the locking piece sequentially penetrates through the first base body through hole and the second base body through hole and then is connected to the fixed through hole.
In the preheating device, the preheating device further comprises a switching pipe, and the first pipeline is communicated with the second pipeline through the switching pipe.
In the preheating device of the application, the preheating device further comprises a quick connector, and the first pipeline is communicated with the second pipeline through the quick connector.
In the preheating device, the first reagent is a latex reagent, the second reagent is a hemolysis agent, and the first pipeline conveys the latex reagent to the first pipeline for preheating under the action of a pressure source; the second pipeline is used for conveying the hemolytic agent to the second pipeline for preheating under the action of a pressure source, then conveying the hemolytic agent to the first pipeline, and conveying the hemolytic agent and the emulsion reagent to the reaction tank after being mixed in the first pipeline.
According to a second aspect of the present application, there is also provided a sample analyzer comprising:
the reaction tank is arranged on the sample analyzer and is provided with a liquid inlet;
a liquid storage device comprising a first reagent liquid supply device for storing the first reagent and a second reagent liquid supply device for storing the second reagent;
the sampling device is used for collecting samples and comprises a sampling needle and a sampling needle driving part for driving the sampling needle to move, wherein the sampling needle driving part drives the sampling needle to collect samples and distributes the collected samples into the reaction tank; and
the preheating device comprises a first pipeline and a second pipeline, one end of the first pipeline, which is far away from the second pipeline, is divided into two paths, one path of the first pipeline is connected to the first reagent liquid supply device, the other path of the first pipeline is connected to the reaction tank, one end of the second pipeline is connected with the first pipeline, and the other end of the second pipeline is connected with the second reagent liquid supply device, so that under the action of a pressure source, a first reagent on the first reagent liquid supply device can be conveyed to the first pipeline for preheating, and a second reagent on the second reagent liquid supply device can be conveyed to the second pipeline for preheating;
After the first reagent on the first pipeline and the second reagent on the second pipeline are preheated, the second pipeline conveys the second reagent to a reaction tank through the first pipeline under the action of a pressure source; and/or the second reagent is conveyed into the first pipeline and conveyed to the reaction tank together with the first reagent in the first pipeline. In the sample analyzer of the present application, the sample analyzer further includes a confluence plate disposed between the reaction tank and the preheating device, the confluence plate is provided with a liquid outflow end and a liquid inlet end, the liquid outflow end is communicated with the liquid inlet, and the first pipeline is conveyed to the reaction tank through the confluence plate.
In the sample analyzer, the sample analyzer further comprises a first control valve and a second control valve, wherein the first control valve is respectively connected with the first pipeline, the first reagent liquid supply device and the reaction tank, and the second control valve is respectively connected with the second pipeline, the pressure source and the second reagent liquid supply device;
the first reagent in the first reagent liquid supply device enters a first pipeline under the control of a pressure source, a first control valve and a second control valve, and is preheated in the first pipeline;
The second reagent in the second reagent liquid supply device enters a second pipeline under the control of a pressure source and a second control valve, and is preheated in the second pipeline;
after the first reagent on the first pipeline and the second reagent on the second pipeline are preheated, the second reagent in the second pipeline is conveyed to the confluence plate through the first pipeline under the control of the pressure source, the first control valve and the second control valve; and/or the second reagent is conveyed into the first pipeline and conveyed to the bus plate together with the first reagent in the first pipeline.
In the sample analyzer of the present application, the sample analyzer further comprises a reaction tank mounting seat, a fixing seat is arranged on one side of the reaction tank mounting seat facing the preheating device, the bus plate is mounted on the fixing seat, and the first control valve and the second control valve are both mounted on the bus plate.
In the sample analyzer of the present application, the fixing base is installed the upper end of reaction cell mount pad, the busbar board is installed the lower extreme of fixing base, first control valve and second control valve are located the below of busbar board.
In the sample analyzer of the application, the bottom of reaction tank mount pad is equipped with the bedplate, the heat accumulation base member on the preheating device is L type structure, the horizontal end of heat accumulation base member is placed on the bedplate, the vertical end of heat accumulation base member is fixed on the lateral wall of reaction tank mount pad.
In the sample analyzer of the present application, be equipped with the pipeline through-hole on the heat accumulation base member, be equipped with the bedplate through-hole on the bedplate, the position of pipeline through-hole with the position of bedplate through-hole is corresponding, so that first pipeline and second pipeline can pass behind pipeline through-hole and the bedplate through-hole with liquid storage device intercommunication.
In the sample analyzer of the present application, the reaction tank mount pad is equipped with the mounting groove, the mounting groove has first opening and second opening, first opening and second opening set up respectively on two terminal surfaces that the reaction tank mount pad is adjacent, the reaction tank passes through first opening is installed on the mounting groove, the application of sample mouth orientation of reaction tank the open-ended direction of second, the inlet orientation the open-ended outside of first.
In the sample analyzer of the present application, be connected with the feed liquor pipeline that is L type structure on the feed liquor mouth, the one end of feed liquor pipeline is followed first opening to the mounting groove extends, the other end of feed liquor pipeline with the busbar links to each other.
In the sample analyzer of the present application, the reaction cell mount is further provided with:
the light-emitting device is arranged on one side of the mounting groove and can emit light into the reaction cavity;
and the receiving device is arranged on the other side of the mounting groove opposite to the light emitting device, and can receive the light scattered by the reaction tank.
In the sample analyzer of the present application, the light incident surface of the mounting groove and the light emitted from the light emitting device to the reaction tank are arranged at an inclined angle.
The technical scheme provided by the embodiment of the application can comprise the following beneficial effects: the application designs a reagent preheating device and sample analysis, which comprises a first pipeline component and a second pipeline component, wherein a first preheating matrix and a first pipeline for conveying a first reagent are arranged on the first pipeline component, and a second preheating matrix and a second pipeline for conveying a second reagent are arranged on the second pipeline component, so that the first reagent on the first pipeline can be preheated through the first preheating matrix and the second reagent on the second pipeline can be preheated through the second preheating matrix; when the first reagent and the second reagent are preheated, the second pipeline conveys the second reagent to the reaction tank through the first pipeline under the action of the pressure source; and/or the second reagent is conveyed into the first pipeline and is conveyed to the reaction tank together with the first reagent in the first pipeline, so that the structure is simple, and the manufacturing cost is low.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a reagent preheating apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic liquid path diagram of the reagent preheating apparatus of FIG. 1;
FIG. 3 is an exploded schematic view of the reagent preheating apparatus of FIG. 1;
FIG. 4 is a partially exploded schematic view of the reagent preheating apparatus of FIG. 1;
FIG. 5 is a partially exploded schematic view of the reagent preheating apparatus of FIG. 1;
FIG. 6 is a schematic view of the second conduit assembly of FIG. 1;
FIG. 7 is a schematic cross-sectional view of the second conduit assembly of FIG. 1;
FIG. 8 is an exploded view of the second conduit assembly of FIG. 1;
FIG. 9 is a schematic diagram of the second pipeline in FIG. 1;
FIG. 10 is a schematic view of the first conduit assembly of FIG. 1;
FIG. 11 is a schematic cross-sectional view of the first conduit assembly of FIG. 1;
FIG. 12 is an exploded view of the first conduit assembly of FIG. 1;
FIG. 13 is a schematic view of the first conduit of FIG. 1;
FIG. 14 is a schematic view of a portion of a sample analyzer according to yet another embodiment of the present application;
FIG. 15 is a partially exploded schematic view of the sample analyzer of FIG. 14;
FIG. 16 is a partially exploded schematic view of the sample analyzer of FIG. 14;
FIG. 17 is a partially exploded schematic view of the sample analyzer of FIG. 14;
fig. 18 is a schematic partial cross-sectional view of the sample analyzer of fig. 14.
Reference numerals illustrate:
100. a preheating device;
10. a first conduit assembly; 11. a first pre-heated substrate; 111. a first base through-hole; 112. a first base spiral groove; 12. a first pipeline; 20. a second conduit assembly; 21. a second preheating substrate; 211. a second base through hole; 212. a second base screw hole; 213. a second base helical groove; 22. a second pipeline; 30. a cover body; 31. a hollow structure; 40. a heat storage matrix; 41. a fixing through hole; 42. a pipeline through hole; 43. a heat storage base fixing portion; 50. a pressure source; 60. a first reagent liquid supply device; 70. a second reagent liquid supply device;
200. A reaction tank; 201. a liquid inlet; 202. a sample adding port; 203. a liquid inlet pipe;
300. a reaction tank mounting seat; 301. a first opening; 302. a second opening; 303. a seat plate; 3031. a seat plate through hole; 304. a light-emitting channel; 305. a light inlet channel;
400. a bus plate; 401. a liquid inlet end; 402. a liquid outflow end;
500. a control valve; 501. a first control valve; 502. a second control valve;
600. a fixing seat;
700. a pressing member;
800. a light emitting device;
900. a receiving device.
Detailed Description
The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all, of the embodiments of the present application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features. In the description of the present invention, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
Some embodiments of the present invention are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.
The reagent preheating device belongs to the technical field of medical instruments, and is applied to a sample analyzer, wherein the sample analyzer comprises one or more of a biochemical analyzer, an immunity analyzer, a blood cell analyzer, a special protein analyzer, a glycosylated hemoglobin analyzer and a blood type analyzer, and is used for detecting and analyzing specific biological components, chemical substances and the like contained in a sample.
In a modern clinical laboratory, a sample analyzer detects specific biological components or chemical substances in a sample through a reaction tank, and in general, a plurality of reagents are not only needed to be used for sample analysis, different reagents are used for mixing and reacting with the sample, and the sample is judged according to a reaction result; and the reaction between the reagent and the sample is usually carried out within a preset temperature range, so that a temperature environment with the temperature within the preset temperature range is required to be provided for the reaction between the sample and the reagent, so that the sample and the reagent are subjected to efficient and full reaction, qualified reaction liquid is provided for each detection, and the accuracy and the repeatability of the detection are improved.
At present, a reagent preheating device is adopted to preheat the reagent, so that the temperature of the reagent is ensured to be within a preset range. However, the conventional reagent presetting device can only preheat one reagent, and cannot preheat two or more reagents simultaneously.
As shown in fig. 1 to 14, according to a first aspect of the present application, there is provided a reagent preheating apparatus 100 including a first line assembly 10 and a second line assembly 20, wherein the first line assembly 10 includes a first preheating substrate 11 and a first line 12, the first line 12 is for transporting a first reagent, and the first preheating substrate 11 is for preheating the first reagent; the second line assembly 20 includes a second preheating substrate 21 and a second line 22, the second line 22 for transporting a second reagent, the second preheating substrate 21 for preheating the second reagent.
In the present embodiment, the diameter D2 of the second pipe 22 is larger than the diameter D1 of the first pipe 12 to ensure that the preheating speed of the first reagent is larger than that of the second reagent, wherein one end of the second pipe 22 is connected to the first pipe 12. When the second pipeline 22 is under the action of the pressure source 50, the second pipeline 22 conveys the second reagent to the reaction tank 200 through the first pipeline 12; and/or the second reagent is delivered to the first conduit 12 and to the reaction cell 200 along with the first reagent in the first conduit 120.
Specifically, one end of the second pipeline 22 is communicated with one end of the first pipeline 12 through a transfer pipe or a quick connector, the other end of the first pipeline 12 is divided into two branches, namely a first branch and a second branch, the first branch is connected to the first reagent liquid supply device 60, and the second branch is connected to the reaction tank 200; the other end of the second conduit 22 is divided into two branches, a third branch and a fourth branch, the third branch being connected to the second reagent feeding apparatus 70, and the fourth branch being connected to the pressure source 50.
After the above technical solution is adopted, when the first reagent flows through the first branch from the first reagent liquid supply device 60 under the control of the pressure source 50, the first reagent enters the first pipeline 12, so that the first preheating substrate 11 can preheat the first reagent in the first pipeline 12; when the second reagent flows from the second reagent feeding apparatus 70 through the third branch under the control of the pressure source 50, the second reagent enters the second pipeline, so that the second preheating substrate 21 can preheat the second reagent in the second pipeline 22. After the preheating of the first reagent on the first pipeline 12 and the second reagent on the second pipeline 22 is completed, the second reagent in the second pipeline 22 is conveyed to the reaction tank 200 through the first pipeline 12 under the control of the pressure source 50; and/or the second reagent is delivered into the first conduit 12 and is delivered to the reaction cell 200 along with the first reagent within the first conduit 12.
It should be noted that, the preheating device 100 of the present application is not limited to the first pipeline assembly 10 and the second pipeline assembly 20, and may be configured according to the type of the reagent required for detection.
In an alternative embodiment, as shown in fig. 4 to 13, the first pipeline 12 is spirally wound on the first preheating substrate 11, and/or the second pipeline 22 is spirally wound on the second preheating substrate 21, so as to ensure that the preheating temperatures of the path sections on the first pipeline 12 and the second pipeline 22 can be kept consistent, and avoid uneven heating of the first reagent and the second reagent and reduced accuracy of detection results.
Specifically, the first pipeline 12 is wound on the outer side of the first preheating substrate 11 along the axial direction of the first preheating substrate 11, the second pipeline 22 is wound on the outer side of the second preheating substrate 21 along the axial direction of the second preheating substrate 21, so that the temperature difference of the first reagent in the axial direction of the first preheating substrate 11 and the temperature difference of the second reagent in the axial direction of the second preheating substrate 21 can be avoided, the flowing direction and the flowing state of the first reagent and the second reagent in the spiral pipeline can be continuously changed, the radial temperature difference of the first reagent and the second reagent in the pipeline is reduced, and the heat exchange enhancement effect is achieved. After the technical scheme is adopted, the first reagent and the second reagent can be ensured to perform efficient and full reaction within a preset temperature range, qualified reaction liquid is provided for each detection, and the detection accuracy and repeatability are improved.
In addition, since the second reagent can be fed into the first pipe 12 and fed to the reaction tank 200 together with the first reagent in the first pipe 12, turbulence and continuous disturbance of the second reagent flowing through the first pipe 12 can be generated by utilizing the characteristic that the diameter D1 of the first pipe 12 is smaller than the diameter D2 of the second pipe 22 and the shape of the first pipe 12, so that uniform mixing can be achieved, and the first reagent and the second reagent can be fully reacted in the first pipe 12.
In an alternative embodiment, the first preheating substrate 11 is provided with a first substrate spiral groove 112, the diameter of the first substrate spiral groove 112 being adapted to the diameter of the first pipe 12, so that the first pipe 12 can be wound around the first preheating substrate 11 in the direction of the first substrate spiral groove 112.
Specifically, the first matrix spiral groove 112 is disposed along the axial direction of the first preheating matrix 11, and the diameter of the first matrix spiral groove 112 is greater than or equal to the diameter D1 of the first pipeline 12, so that the contact area between the first pipeline 12 and the first preheating matrix 11 can be increased, the preheating effect of the first reagent in the first pipeline 12 is improved, the first pipeline 12 can be more firmly fixed on the first preheating matrix 11, and the first pipeline 12 is ensured to be tightly attached to the first preheating matrix 11.
In an alternative embodiment, the second preheating substrate 21 is provided with a second substrate spiral groove 213, the diameter of the second substrate spiral groove 213 being adapted to the diameter of the second pipe 22, so that the second pipe can be wound around the second preheating substrate 21 in the direction of the second substrate spiral groove 213.
Specifically, the second substrate spiral groove 213 is disposed along the axial direction of the second preheating substrate 21, and the diameter of the second substrate spiral groove 213 is greater than or equal to the diameter D2 of the second pipeline 22, so that not only the contact area between the second pipeline 22 and the second preheating substrate 21 can be increased, and the preheating effect of the second reagent in the second pipeline 22 is improved, but also the second pipeline 22 can be more firmly fixed on the second preheating substrate 21, and the second pipeline 22 is ensured to be tightly attached to the second preheating substrate 21.
In an alternative embodiment, the first and second conduits 12, 22 are each coated with insulation wool on the outside for insulating the first reagent in the first conduit 12 and the second reagent in the second conduit 22.
Specifically, the heat-insulating cotton may be wound around the outer sides of the first pipeline 12 and the second pipeline 22, or the heat-insulating cotton may be wound around the outer sides of the first preheating substrate 11 and the second preheating substrate 21, so that the heat-insulating cotton can cover the first pipeline 12 and the second pipeline 22 when the first pipeline 12 and the second pipeline 22 are respectively installed on the first preheating substrate 11 and the second preheating substrate 21, and thus, the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22 can be insulated.
In an alternative embodiment, the preheating device 100 further includes a housing 30, the housing 30 has a hollow structure 31, and the first pipeline assembly 10 and the second pipeline assembly 20 are both installed in the hollow structure 31, so as to avoid the first pipeline 12 and the second pipeline 22 from being directly exposed to the outside, thereby better protecting the first pipeline 12 and the second pipeline 22. In addition, the heat-insulating cotton can be further arranged on the inner wall of the hollow structure 31, so that when the first pipeline assembly 10 and the second pipeline assembly 20 are installed in the hollow structure 31, the heat-insulating cotton can wrap the first pipeline 12 and the second pipeline 22, and therefore heat insulation can be achieved on the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22.
In an alternative embodiment, the first preheating substrate 11 is installed at the upper end of the second preheating substrate 21, and the diameter of the first preheating substrate 11 is equal to that of the second preheating substrate 21, so that heat can be transferred to the first preheating substrate 11 through the second preheating substrate 21, and the first reagent in the first pipeline 12 and the first reagent in the second pipeline 22 can be preheated simultaneously by the first preheating substrate 11 and the second preheating substrate 21, and the whole preheating device 100 can be more compact in structure, so that the occupied area of the preheating device 100 is reduced, and the cost is saved.
It should be noted that the first preheating substrate 11 and the second preheating substrate 21 are made of the same heat conductive material, so that the first preheating substrate 11 and the second preheating substrate 21 can have the same preheating temperature, and the preheating speeds of the first reagent and the second reagent can be respectively adjusted by the diameters of the first pipeline 12 and the second pipeline 22. Wherein the pipe diameter of the first pipe 12 is larger and the pipe diameter of the second pipe 22 is smaller, so that the preheating speed of the first reagent is larger than that of the second reagent.
In addition, the first preheating substrate 11 and the second preheating substrate 21 may be made of different heat conductive materials according to the difference of the preheating speeds between the first reagent and the second reagent, and the first preheating substrate 11 and the second preheating substrate 21 may be integrally formed, which is not limited in this application.
In an alternative embodiment, the preheating device 100 includes a heat storage matrix 40 and a heating source, wherein the heat storage matrix 40 is provided with a matrix mounting portion, the lower end of the second preheating matrix 21 is mounted on the matrix mounting portion, the heating source is used for heating the heat storage matrix 40, and the heat storage matrix 40 transfers heat to the second preheating matrix 21 and the first preheating matrix 11 mounted on the upper end of the second preheating matrix 21, so that the first preheating matrix 11 and the second preheating matrix 21 can preheat the first reagent in the first pipeline 12 and the second reagent in the second pipeline 22, respectively.
In an alternative embodiment, the preheating device 100 includes a locking member, the base mounting portion is provided with a fixing through hole 41, the first preheating base 11 is provided with a first base through hole 111, and the second preheating base 21 is provided with a second base through hole 211. In the present embodiment, the first base through-hole 111 penetrates through the upper and lower ends of the first preheating base 11, and the second base through-hole 211 penetrates through the upper and lower ends of the second preheating base 21, so that the locking member can be connected to the fixing through-hole 41 after sequentially penetrating through the first base through-hole 111 and the second base through-hole 211.
In an alternative embodiment, the locking member includes two bolts, wherein the second preheating substrate through hole 211 is a screw hole provided at an upper end of the second preheating substrate 21, and the second preheating substrate 21 is provided at a lower end thereof with a second substrate screw hole 212, so that one of the bolts can be screwed to the second substrate through hole 211 through the first substrate through hole 111, and the other screw can be screwed to the second substrate screw hole 212 after passing through the fixing through hole 41, thereby mounting the first preheating substrate 11, the second preheating substrate 21, and the heat storage substrate 40 together in a stacked manner.
After the technical scheme is adopted, the forming processing of the first preheating substrate 11 and the second preheating substrate 21 is facilitated, and particularly, the first substrate spiral groove 112 and the second substrate spiral groove 213 with different diameters are formed in the first preheating substrate 11 and the second preheating substrate 21, meanwhile, the length of the locking piece can be shortened, the strength of the locking piece is effectively improved, and the preheating temperature of the first preheating substrate 11 and the second preheating substrate 21 with consistency is ensured more easily.
In an alternative embodiment, the preheating device 100 further comprises a transfer tube, so that the first pipeline 12 can be communicated with the second pipeline 22 through the transfer tube, which is simple in structure and convenient for connecting the two pipelines together.
In an alternative embodiment, the preheating device 100 further comprises a quick connector, so that the first pipeline 12 can be communicated with the second pipeline 22 through the quick connector, which is simple in structure and convenient for connecting the two pipelines together.
In an alternative embodiment, the first reagent is a latex reagent and the second reagent is a hemolyzing agent, wherein the first pipeline 12 is supplied with the latex reagent to the first pipeline 12 for preheating under the action of the pressure source 50; the second pipeline 22 conveys the hemolytic agent to the second pipeline 22 for preheating under the action of the pressure source 50; after the latex reagent in the first pipeline 12 and the hemolytic agent in the second pipeline 22 are preheated, the second pipeline 22 conveys the hemolytic agent in the second pipeline 22 to the first pipeline 12 under the action of the pressure source 50, so that the hemolytic agent and the latex reagent can be mixed in the first pipeline 12 and then conveyed to the reaction tank 200.
As shown in fig. 1 to 18, according to a second aspect of the present application, there is provided a sample analyzer comprising a liquid storage device, a reaction cell 200, a preheating device 100 as described above, and a sampling device for collecting an analysis sample, wherein the reaction cell 200 is mounted on the sample analyzer, the liquid storage device comprising a first reagent liquid supply device 60 for storing a first reagent and a second reagent liquid supply device 70 for storing a second reagent; the sampling device comprises a sampling needle and a sampling needle driving part for driving the sampling needle to move, wherein the sampling needle driving part drives the sampling needle to collect samples and distributes the collected samples into the reaction tank.
In this embodiment, one end of the first pipeline 12 far away from the second pipeline 22 is divided into two paths, one path is connected to the first reagent liquid supply device 60, the other path is connected to the reaction tank 200, and the other end of the second pipeline 22 is connected to the second reagent liquid supply device 70, so that the first reagent on the first reagent liquid supply device 60 can be conveyed to the first pipeline 12 for preheating under the action of the pressure source 50 by the first pipeline 12 and the second pipeline 22, and the second reagent on the second reagent liquid supply device 70 can be conveyed to the second pipeline 22 for preheating; after the first reagent on the first pipeline 12 and the second reagent on the second pipeline 22 are preheated, the second pipeline 22 conveys the second reagent to the reaction tank 200 through the first pipeline 12 under the action of the pressure source 50; and/or the second reagent is delivered into the first conduit 12 and is delivered to the reaction cell 200 along with the first reagent within the first conduit 12.
Specifically, a sample adding port 202 and a liquid inlet 201 are arranged on the reaction tank 200, wherein the direction of the sample adding port 202 is upward, the liquid inlet 201 is communicated with the second branch, so that a sample can be conveniently and directly added from the sample adding port 202 above the reaction tank 200 by a sampling needle, the sample can be mixed with a first reagent and a second reagent led in by the liquid inlet 201 for reaction, and then the result of the reaction of the sample and the reagent is detected by a detection device on the reaction tank 200, so that the reaction device is simple in structure and practical.
In an alternative embodiment, the sample analyzer further comprises a manifold 400 arranged between the reaction cell 200 and the preheating device 100, the manifold 400 being provided with a liquid outflow end 402 and a liquid inflow end 401, wherein the liquid outflow end 402 communicates with the liquid inlet 201 and the liquid inflow end 401 communicates with the second branch, such that the first reagent and/or the second reagent on the first line 12 can be transported via the manifold 400 to the reaction cell 200.
In an alternative embodiment, the sample analyzer further includes a control valve 500, where the control valve 500 is mounted on the manifold 400, so that the flow of the liquid on the first pipeline 12 and the second pipeline 22 can be conveniently controlled, and the structure of the sample analyzer can be more compact.
Specifically, the control valve 500 includes a first control valve 501 and a second control valve 502, where the first control valve 501 is connected to the first pipeline 12, the first reagent liquid supply device 60 and the reaction tank 200, and the second control valve 502 is connected to the second pipeline 22, the pressure source 50 and the second reagent liquid supply device 70, respectively; so that the first reagent in the first reagent-feeding apparatus 60 enters the first pipe 12 under the control of the pressure source 50, the first control valve 501 and the second control valve 502 and is preheated in the first pipe 12; and the second reagent in the second reagent liquid supply device 70 enters the second pipeline 22 under the control of the pressure source 50 and the second control valve 502, and is preheated in the second pipeline 22; after the preheating of the first reagent on the first pipe 12 and the second reagent on the second pipe 22 is completed, the second reagent in the second pipe 22 is transferred to the confluence plate 400 through the first pipe 12 under the control of the pressure source 50, the first control valve 501 and the second control valve 502; and/or the second reagent is delivered into the first pipe 12 and delivered to the manifold plate 400 together with the first reagent in the first pipe 12.
The first control valve 501 divides the first pipeline 12 into a first branch and a second branch, the second control valve 502 divides the second pipeline 22 into a third branch and a fourth branch, and when the first control valve 501 controls the first pipeline 12 to communicate with the first branch and the second control valve 502 controls the second pipeline 22 to communicate with the fourth branch, the first reagent in the first reagent liquid supply device 60 can enter the first pipeline 12 under the control of the pressure source 50; when the second control valve 502 controls the second line 22 to communicate with the third branch, the second reagent in the second reagent-feeding apparatus 70 can enter the second line 22 under the control of the pressure source 50; when the preheating of the first reagent on the first pipeline 12 and the second reagent on the second pipeline 22 is completed, the first control valve 501 controls the first pipeline 12 to communicate with the second branch and the second control valve 502 controls the second pipeline 22 to communicate with the fourth branch, so that the second reagent in the second pipeline 22 can be conveyed to the bus plate 400 through the first pipeline 12; and/or the second reagent in the second conduit 22 is delivered into the first conduit 12 and delivered to the manifold 400 along with the first reagent in the first conduit 12.
In an alternative embodiment, the sample analyzer further includes a reaction cell mounting seat 300, and a fixing seat 600 is disposed on a side of the reaction cell mounting seat 300 facing the preheating device 100, wherein the confluence plate 400 is mounted on the fixing seat 600, and the first control valve 501 and the second control valve 502 are mounted on the confluence plate 400, so that the first control valve 501, the second control valve 502 and the confluence plate 400 can be mounted between the reaction cell mounting seat 300 and the preheating device 100, which not only makes the structure of the sample analyzer more compact, but also facilitates the arrangement of pipes among the preheating device 100, the first control valve 501, the second control valve 502, the confluence plate 400 and the reaction cell 200.
In an alternative embodiment, the fixing base 600 is installed at the upper end of the reaction tank installation base 300, the confluence plate 400 is installed at the lower end of the fixing base 600, and the first control valve 501 and the second control valve 502 are located below the confluence plate, so that not only connection of the first pipeline 12 and the second pipeline 22 with the first control valve 501 and the second control valve 502, but also communication between the first pipeline 12 and the liquid inlet end 401 and communication between the liquid outlet end 402 and the reaction tank 200 are facilitated.
In an alternative embodiment, the bottom of the reaction tank mount 300 is provided with a seat plate 303, wherein the heat storage matrix 40 on the preheating device 100 has an L-shaped structure. In the present embodiment, the thermal storage matrix fixing portion 43 is provided on the vertical end of the thermal storage matrix, and when the horizontal end of the thermal storage matrix 40 can be placed on the seat plate 303, the thermal storage matrix fixing portion 43 can be fixed on the side wall of the reaction tank mounting seat 300, so that the thermal storage matrix 40 can be firmly fixed on the reaction tank mounting seat 300.
In an alternative embodiment, the heat storage matrix 40 is provided with a pipe through hole 42, and the seat plate 303 is provided with a seat plate through hole 3031, wherein the position of the pipe through hole 42 corresponds to the position of the seat plate through hole 3031, so that the first pipe 12 and the second pipe 22 can pass through the pipe through hole 42 and the seat plate through hole 3031 and then communicate with the liquid storage device.
In an alternative embodiment, the reaction tank mount 300 is provided with a mounting groove having a first opening 301 and a second opening 302, wherein the first opening 301 and the second opening 302 are respectively provided on two end surfaces adjacent to the reaction tank mount 300, and when the reaction tank 200 is mounted on the mounting groove through the first opening 301, the sample loading opening 202 of the reaction tank 200 faces the direction of the second opening 302, and the liquid inlet 201 faces the outside of the first opening 301.
In an alternative embodiment, the liquid inlet 201 is connected with a liquid inlet pipe 203 having an L-shaped structure, one end of the liquid inlet pipe 203 extends from the first opening 301 to the mounting groove, and the other end of the liquid inlet pipe 203 is connected with the liquid outlet end 402 of the bus plate 400.
In this embodiment, the liquid inlet 201 is disposed at the bottom of the reaction tank 200, and the liquid inlet pipeline 203 is in a 90 ° bent L-shaped structure, so that the reagent on the liquid outlet 402 can be conveniently introduced into the reaction tank 200 from the liquid inlet 201 through the liquid inlet pipeline 203, thus not only facilitating the arrangement of the liquid inlet pipeline 203, but also facilitating the mixing of the reagent with the sample in the reaction tank 200 directly under the control of the pressure source 50.
In an alternative embodiment, the reaction cell mount further includes a hold-down member 700 for securing the reaction cell 200 to the mounting groove.
In an alternative embodiment, the reaction cell mount is further provided with a light emitting device 800 and a receiving device 900, wherein the light emitting device 800 is mounted at one side of the mounting groove and the receiving device 900 is mounted at the other side of the mounting groove opposite to the light emitting device 800. In this embodiment, the light emitting device 800 can emit light to the reaction cell 200, the receiving device 900 can receive the light scattered from the reaction cell 200 and convert the light into an electrical signal, and then the sample analyzer calculates the detection structure and analysis data of the sample according to the electrical signal transmitted from the receiving device 900.
Specifically, after the light emitting device 800 emits light to the reaction cell 200, a portion of the light is scattered by the sample molecules or particles inside the reaction cell 200 and then received by the receiving device 900, and the light passing through the reaction cell 200 vertically passes through another channel of the reaction cell mount 300 and is not received by the receiving device 900.
In an alternative embodiment, the light incident surface of the mounting groove is disposed at an inclined angle to the light emitted from the light emitting device 800 to the reaction cell 200.
Specifically, the reaction tank mounting seat 300 is provided with a light outlet channel 304 and a light inlet channel 305, and light generated by the light emitting device 800 enters the reaction tank 200 through the light outlet channel 304, is reflected or scattered by the reaction tank 200, and is captured by the receiving device 900 through the light inlet channel 305. In this embodiment, the light-emitting channel 304 and the light-entering channel 305 are disposed at an angle, the angle between the light-emitting channel 304 and the light-entering channel 305 is 90-150 °, that is, the light-emitting device 800 emits light to the reaction cell 200, and the light is captured by the receiving device 900 after being scattered by the reaction cell 200.
The light emitting channel 304 is disposed at an inclined angle with the light incident surface of the mounting groove, wherein the light incident surface of the mounting groove is a plane of the mounting groove near one side of the light emitting channel 304, so that the light reflected from the reaction tank 200 can be offset, different paths between the reflected light and the light emitted by the light emitting device 800 are ensured, and the light emitted by the light emitting device 800 is prevented from interfering the light emitting device 800 due to the reflection of the reaction tank 200.
In the description of the present invention, it should be noted that the terms "mounted," "connected," and "coupled" are to be construed broadly, as well as, for example, fixedly coupled, detachably coupled, or integrally coupled, unless otherwise specifically indicated and defined. Either mechanically or electrically. Can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present invention, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.
The above disclosure provides many different embodiments, or examples, for implementing different structures of the invention. The foregoing description of specific example components and arrangements has been presented to simplify the present disclosure. They are, of course, merely examples and are not intended to limit the invention. Furthermore, the present invention may repeat reference numerals and/or letters in the various examples, which are for the purpose of brevity and clarity, and which do not themselves indicate the relationship between the various embodiments and/or arrangements discussed. In addition, the present invention provides examples of various specific processes and materials, but one of ordinary skill in the art will recognize the application of other processes and/or the use of other materials.
In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the invention, the scope of which is defined by the claims and their equivalents.
Claims (22)
1. A reagent preheating apparatus, comprising:
a first conduit assembly comprising a first preheating substrate and a first conduit for transporting a first reagent, the first preheating substrate being for preheating the first reagent;
The second pipeline assembly comprises a second preheating matrix and a second pipeline for conveying a second reagent, one end of the second pipeline is connected with the first pipeline, the second preheating matrix is used for preheating the second reagent, and the second pipeline is used for conveying the second reagent to the reaction tank through the first pipeline under the action of a pressure source; the second reagent is conveyed into the first pipeline and conveyed to the reaction tank together with the first reagent in the first pipeline;
wherein the diameter of the second pipeline is larger than the diameter of the first pipeline, so that the preheating speed of the first reagent is larger than the preheating speed of the second reagent.
2. The preheating device according to claim 1, wherein the first pipe is spirally wound around the first preheating substrate and/or the second pipe is spirally wound around the second preheating substrate.
3. The preheating device according to claim 2, wherein a first base spiral groove is formed in the first preheating base, the diameter of the first base spiral groove is matched with the diameter of the first pipeline, and the first pipeline is wound on the first base spiral groove.
4. The preheating device according to claim 2, wherein a second base spiral groove is provided on the second preheating base, the diameter of the second base spiral groove is adapted to the diameter of the second pipeline, and the second pipeline is wound around the second base spiral groove.
5. The preheating device according to any one of claims 1 to 4, wherein the outside of each of the first and second pipelines is covered with heat insulating cotton for insulating the first reagent in the first pipeline and the second reagent in the second pipeline.
6. The preheating device according to any one of claims 1 to 4, wherein the first preheating substrate is installed at an upper end of the second preheating substrate, and a diameter of the first preheating substrate is equal to a diameter of the second preheating substrate.
7. The preheating device according to claim 6, wherein the preheating device comprises a heat storage substrate on which a substrate mounting portion is provided, and a heating source for heating the heat storage substrate, the lower end of the second preheating substrate being mounted on the substrate mounting portion.
8. The preheating device according to claim 7, wherein the preheating device comprises a locking member, the base mounting portion is provided with a fixing through hole, the first preheating base is provided with a first base through hole, the second preheating base is provided with a second base through hole, and the locking member sequentially passes through the first base through hole and the second base through hole and then is connected to the fixing through hole.
9. The preheating device according to any one of claims 1 to 4, further comprising a transfer pipe through which the first pipe communicates with the second pipe.
10. The preheating device according to any one of claims 1 to 4, further comprising a quick connector, through which the first pipe communicates with the second pipe.
11. The preheating device according to any one of claims 1 to 4, wherein the first reagent is a latex reagent, the second reagent is a hemolyzing agent, and the first pipeline is used for conveying the latex reagent to the first pipeline for preheating under the action of a pressure source; the second pipeline is used for conveying the hemolytic agent to the second pipeline for preheating under the action of a pressure source, then conveying the hemolytic agent to the first pipeline, and conveying the hemolytic agent and the emulsion reagent to the reaction tank after being mixed in the first pipeline.
12. A sample analyzer, comprising:
the reaction tank is arranged on the sample analyzer and is provided with a liquid inlet;
a liquid storage device comprising a first reagent liquid supply device for storing a first reagent and a second reagent liquid supply device for storing a second reagent;
The sampling device is used for collecting samples and comprises a sampling needle and a sampling needle driving part for driving the sampling needle to move, wherein the sampling needle driving part drives the sampling needle to collect samples and distributes the collected samples into the reaction tank; and
the preheating device comprises a first pipeline and a second pipeline, one end of the first pipeline, which is far away from the second pipeline, is divided into two paths, one path of the first pipeline is connected to the first reagent liquid supply device, the other path of the first pipeline is connected to the reaction tank, one end of the second pipeline is connected with the first pipeline, and the other end of the second pipeline is connected with the second reagent liquid supply device, so that under the action of a pressure source, a first reagent on the first reagent liquid supply device can be conveyed to the first pipeline for preheating, and a second reagent on the second reagent liquid supply device can be conveyed to the second pipeline for preheating;
after the first reagent on the first pipeline and the second reagent on the second pipeline are preheated, the second pipeline conveys the second reagent to a reaction tank through the first pipeline under the action of a pressure source; the second reagent is conveyed into the first pipeline and conveyed to the reaction tank together with the first reagent in the first pipeline.
13. The sample analyzer of claim 12, further comprising a manifold plate disposed between the reaction cell and the pre-heating device, the manifold plate having a liquid outflow end and a liquid inflow end, the liquid outflow end in communication with the liquid inlet, the first conduit being routed through the manifold plate to the reaction cell.
14. The sample analyzer of claim 13, further comprising a first control valve and a second control valve, wherein the first control valve is connected to the first conduit, the first reagent supply and the reaction cell, respectively, and the second control valve is connected to the second conduit, the pressure source and the second reagent supply, respectively;
the first reagent in the first reagent liquid supply device enters a first pipeline under the control of a pressure source, a first control valve and a second control valve, and is preheated in the first pipeline;
the second reagent in the second reagent liquid supply device enters a second pipeline under the control of a pressure source and a second control valve, and is preheated in the second pipeline;
after the first reagent on the first pipeline and the second reagent on the second pipeline are preheated, the second reagent in the second pipeline is conveyed to the confluence plate through the first pipeline under the control of the pressure source, the first control valve and the second control valve; the second reagent is conveyed into the first pipeline and conveyed to the bus plate together with the first reagent in the first pipeline.
15. The sample analyzer of claim 14, further comprising a reaction cell mount, wherein a side of the reaction cell mount facing the preheating device is provided with a fixing base, wherein the manifold is mounted on the fixing base, and wherein the first control valve and the second control valve are both mounted on the manifold.
16. The sample analyzer of claim 15, wherein the holder is mounted at an upper end of the reaction cell mount, the manifold plate is mounted at a lower end of the holder, and the first and second control valves are located below the manifold plate.
17. The sample analyzer of claim 15, wherein a base plate is provided at the bottom of the reaction cell mounting base, the heat storage matrix on the preheating device has an L-shaped structure, the horizontal end of the heat storage matrix is placed on the base plate, and the vertical end of the heat storage matrix is fixed on the side wall of the reaction cell mounting base.
18. The sample analyzer of claim 17, wherein the thermal storage substrate is provided with a pipe through hole, the seat plate is provided with a seat plate through hole, and the position of the pipe through hole corresponds to the position of the seat plate through hole, so that the first pipe and the second pipe can be communicated with the liquid storage device after passing through the pipe through hole and the seat plate through hole.
19. The sample analyzer of claim 15, wherein the reaction cell mount is provided with a mounting groove, the mounting groove is provided with a first opening and a second opening, the first opening and the second opening are respectively arranged on two adjacent end surfaces of the reaction cell mount, the reaction cell is mounted on the mounting groove through the first opening, a sample loading port of the reaction cell faces the direction of the second opening, and a liquid inlet faces the outer side of the first opening.
20. The sample analyzer of claim 19, wherein the liquid inlet is connected with a liquid inlet pipe having an L-shaped structure, one end of the liquid inlet pipe extends from the first opening to the mounting groove, and the other end of the liquid inlet pipe is connected with the bus plate.
21. The sample analyzer of claim 19, wherein the reaction cell mount is further provided with:
the light-emitting device is arranged on one side of the mounting groove and can emit light into the reaction cavity;
and the receiving device is arranged on the other side of the mounting groove opposite to the light emitting device, and can receive the light scattered by the reaction tank.
22. The sample analyzer of claim 21, wherein the light incident surface of the mounting groove is disposed at an oblique angle to the light emitted from the light emitting device to the reaction cell.
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| CN201911359193.9A CN113030480B (en) | 2019-12-25 | 2019-12-25 | Reagent preheating device and sample analyzer |
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