CN112244957A - Continuous sustained release drug delivery catheter with puncture sheath - Google Patents
Continuous sustained release drug delivery catheter with puncture sheath Download PDFInfo
- Publication number
- CN112244957A CN112244957A CN202011183369.2A CN202011183369A CN112244957A CN 112244957 A CN112244957 A CN 112244957A CN 202011183369 A CN202011183369 A CN 202011183369A CN 112244957 A CN112244957 A CN 112244957A
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- Prior art keywords
- tube
- outer sheath
- drug
- release
- storage bag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000013268 sustained release Methods 0.000 title claims abstract description 16
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 16
- 238000012377 drug delivery Methods 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 104
- 229940079593 drug Drugs 0.000 claims abstract description 52
- 238000002347 injection Methods 0.000 claims abstract description 47
- 239000007924 injection Substances 0.000 claims abstract description 47
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 239000002114 nanocomposite Substances 0.000 claims description 6
- 239000013013 elastic material Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 11
- 230000036407 pain Effects 0.000 abstract description 6
- 210000000416 exudates and transudate Anatomy 0.000 abstract 1
- 238000001647 drug administration Methods 0.000 description 8
- 239000004677 Nylon Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920001778 nylon Polymers 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000025978 Athletic injury Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010041738 Sports injury Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3415—Trocars; Puncturing needles for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Molecular Biology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
本发明提供一种具有穿刺外鞘的连续缓释给药留置管，包括注药管、缓释管，缓释管的轴向一端封闭，缓释管的轴向另一端与注药管的出口贯通连接，注药管的进口连接有储药囊，储药囊上具有注药口，外部药液能够经由注药口进入储药囊内，进而经由注药管并经由缓释管的管壁渗出至其外侧；还包括由第一外鞘壳体、第二外鞘壳体可拆卸地组合为一体形成的穿刺外鞘，穿刺外鞘具有中空管腔，注药管穿行于中空管腔中；和/或，缓释管穿行于中空管腔中。本发明的具有穿刺外鞘的连续缓释给药留置管，避免对需多次给药的患者的反复穿刺，无需对给药范围广的患者多点穿刺，降低病患医疗过程中的痛苦，改善病患的就医体验。
The invention provides a continuous sustained-release drug delivery indwelling tube with a puncture outer sheath, which includes a drug injection tube and a sustained-release tube. Through connection, the inlet of the medicine injection tube is connected with a medicine storage bag, and the medicine storage bag has a medicine injection port, and the external medicinal liquid can enter the medicine storage bag through the medicine injection port, and then pass through the medicine injection tube and through the tube wall of the slow-release tube. Exudate to its outside; also includes a puncture outer sheath formed by detachably combining the first outer sheath shell and the second outer sheath shell, the puncture outer sheath has a hollow lumen, and the drug injection tube passes through the hollow lumen and/or, the slow-release tube runs through the hollow lumen. The continuous sustained-release administration indwelling tube with a puncture outer sheath of the present invention avoids repeated puncturing of patients who need multiple administrations, does not require multiple punctures for patients with a wide range of administration, and reduces the pain of patients during the medical treatment process. Improve the patient's medical experience.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a continuous slow-release drug administration indwelling tube with a puncture sheath.
Background
For many patients with sports injury, a local nerve blocking method is often needed to relieve pain and eliminate inflammation, and for some patients with substantial tumors, a tumor body injection method can be used to kill tumor cells. However, the prior art only can carry out single administration, and patients who need to carry out multiple administrations have to puncture repeatedly, which undoubtedly increases the pain of the patients; in addition, during administration, the medicine only can be intensively effused from the outlet of the administration tube, and the medicine is often gathered at the outlet and can not be diffused to a sufficiently far area, so that for some patients needing wide administration range, the medicine has to be administered by multi-point puncture, and for the patients adopting percutaneous puncture area continuous administration treatment (such as analgesia, chemotherapy and the like), the invention is provided on the basis that the long-time uniform local administration can not be realized in a good mode.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide a continuous slow-release drug administration indwelling tube with a puncture sheath, which avoids repeated puncture on a patient needing multiple drug administrations, does not need to puncture the patient at multiple points with a wide drug administration range, reduces pain of the patient in the medical treatment process, and improves the medical experience of the patient.
In order to solve the problems, the invention provides a continuous slow-release drug administration indwelling tube with a puncture sheath, which comprises a drug injection tube and a slow-release tube, wherein one axial end of the slow-release tube is closed, the other axial end of the slow-release tube is communicated with an outlet of the drug injection tube, an inlet of the drug injection tube is connected with a drug storage bag, a drug injection port is formed in the drug storage bag, external drug liquid can enter the drug storage bag through the drug injection port, and then the external drug liquid can seep out of the drug injection tube through the tube wall of the slow-release tube to the outer side of the drug storage bag; the puncture sheath is formed by combining a first sheath shell and a second sheath shell in a detachable mode, and is provided with a hollow cavity, and the medicine injection pipe penetrates through the hollow cavity; and/or the slow release tube passes through the hollow tube cavity.
Preferably, the medicine storage bag is made of an elastic material, so that the medicine liquid in the medicine storage bag is forced into the medicine injection tube by utilizing the elastic retraction of the medicine storage bag.
Preferably, a check valve is arranged in the medicine injection port.
Preferably, the slow release tube is made of medical hydrophilic and hydrophobic nano composite materials.
Preferably, the medical hydrophilic and hydrophobic nanocomposite comprises one of a fluoropolymer and a polyurethane.
Preferably, the medicine storage bag is detachably connected with the medicine injection tube; and/or the medicine injection tube and the slow release tube are connected into a whole.
Preferably, the first sheath housing and the second sheath housing are combined into a whole through a sliding structure.
Preferably, the penetrating sheath has a sheath core thereon.
Preferably, the drug injection port is in through connection with the drug storage bag through a connecting pipe.
According to the continuous slow-release drug delivery indwelling tube with the puncture sheath, provided by the invention, through the design of the drug storage bag and the slow-release tube, medical staff can puncture once to achieve the purposes of multi-point puncture and repeated puncture in the prior art, liquid medicine in the drug storage bag, the drug injection tube and the slow-release tube can slowly permeate and seep to indwelling target tissues of a patient through the slow-release tube, the tube length of the slow-release tube can cover a larger drug delivery area, and the patient with a wide drug delivery range does not need to be punctured at multiple points and repeatedly punctured, so that the pain of the patient in the medical treatment process is reduced, and the medical experience of the patient is improved; in addition, the puncture sheath is assembled by the first sheath shell and the second sheath shell and can be detached and separated, so that the puncture sheath can be detached and withdrawn from the target puncture tissue after puncture is completed.
Drawings
FIG. 1 is a schematic structural view of a continuous sustained release administration indwelling tube having a penetrating outer sheath according to an embodiment of the present invention.
The reference numerals are represented as:
1. a medicine injection tube; 2. a medicine storage bag; 21. a medicine injection port; 22. a connecting pipe; 3. a slow release tube; 41. a first sheath housing; 42. a second sheath housing.
Detailed Description
Referring to fig. 1, according to an embodiment of the present invention, a continuous sustained-release drug administration indwelling tube with a puncture outer sheath is provided, which includes a drug injection tube 1 and a sustained-release tube 3, one axial end of the sustained-release tube 3 is closed, the other axial end of the sustained-release tube 3 is connected to an outlet of the drug injection tube 1 in a penetrating manner, an inlet of the drug injection tube 1 is connected to a drug storage bag 2, the drug storage bag 2 is provided with a drug injection port 21, and external drug liquid can enter the drug storage bag 2 through the drug injection port 21, and further seep to the outside of the drug injection tube 1 through a tube wall of the sustained-release tube 3; the puncture sheath is formed by detachably combining a first sheath shell 41 and a second sheath shell 42 into a whole, the puncture sheath is provided with a hollow cavity, and the medicine injection tube 1 passes through the hollow cavity; and/or the slow release pipe 3 passes through the hollow pipe cavity. In the technical scheme, through the design of the medicine storage bag 2 and the slow release tube 3, the aim of multi-point puncture and repeated puncture in the prior art can be fulfilled by medical workers only by puncturing once, liquid medicines in the medicine storage bag 2, the medicine injection tube 1 and the slow release tube 3 can slowly permeate and seep to indwelling target tissues of a patient through the slow release tube 3, the tube length of the slow release tube 3 can cover a larger medicine administration area, and the patient with a wide medicine administration range does not need to be punctured at multiple points and repeatedly punctured, so that the pain of the patient in the medical treatment process is reduced, and the medical experience of the patient is improved; the puncture sheath is detachably divided by the first sheath housing 41 and the second sheath housing 42, so that the puncture sheath can be easily detached from the target puncture tissue after the puncture is completed.
Preferably, the drug storage bag 2 is made of an elastic material, so as to utilize the elastic retraction of the drug storage bag 2 to force the drug solution therein into the drug injection tube 1, it is understood that the elastic material should be a medical material, and in terms of the selection of the elastic force, it should match the exudation rate of the slow release tube 3, so as to prevent the drug solution from exuding too fast or too slow in the drug administration process. The slow release tube 3 is made of medical hydrophilic and hydrophobic nano composite materials, specifically, the medical hydrophilic and hydrophobic nano composite materials can comprise one of fluorine-containing macromolecules and polyurethane, and the pore diameter of a permeation hole on the slow release membrane is 1-100 nm. It is further noted that the cooperation of the elastic medicine storage bag 2 and the slow release tube 3 makes the administration more durable and uniform.
Preferably, the medicine storage bag 3 is made of an elastic material, and specifically, for example, one of silica gel, rubber, latex or nylon can be used, wherein the formable wall thickness of the silica gel is 0.2-0.4mm, the shore softness is 30, the medicine storage bag can be manufactured by injection molding or bonding technology, the elasticity is good, the product performance is stable, the medicine storage bag is transparent, and the medicine storage bag can be beneficial for an operator to observe the liquid medicine condition in the bag; the formable wall thickness of the rubber is 0.5-0.8mm, the Shore softness is 40, the formable wall can be manufactured by adopting an injection molding or bonding process, the formable wall has general elasticity, the appearance is rough, the hardness is high, the formable wall is mostly white, and the liquid medicine condition in the capsule can not be observed; the formable wall thickness of the latex is 0.2-1mm, the Shore softness is 20-30, the formable latex can be manufactured by adopting an injection molding or bonding process, the formable latex has moderate elasticity, the appearance is not fine and smooth enough, the formable latex is semitransparent, and the forming effect is not good; the wall thickness of the formable nylon is 0.2-0.6mm, the formable nylon can be manufactured by adopting a bonding process, the formable nylon has poor elasticity and is semitransparent, and therefore, the formable nylon is best, and the medicine storage bag 3 is made of silica gel.
A check valve is arranged in the medicine injection port 21 to prevent the backflow and leakage of the medicine liquid.
The medicine storage bag 2 is detachably connected with the medicine injection tube 1, so that the application of the indwelling tube is more convenient and flexible; and/or the medicine injection tube 1 and the slow release tube 3 are connected into a whole to prevent the liquid medicine from leaking at the joint.
Further, the first sheath housing 41 and the second sheath housing 42 are combined into a whole through a sliding structure, for example, a sliding rail (sliding groove) is located at a position where the first sheath housing 41 and the second sheath housing 42 are in relative contact, the sliding rail is located on the first sheath housing 41, at this time, a sliding block is formed at a corresponding position of the second sheath housing 42, the sliding block is embedded in the sliding rail in a matching manner, so that the puncture sheath can be withdrawn from the target indwelling tissue after the puncture is completed, and preferably, the puncture sheath has a sheath core to facilitate the puncture process.
The drug injection port 21 is in through connection with the drug storage bag 2 through a connecting pipe 22, and the connecting pipe 22 has flexibility, so that medical staff can conveniently select the drug administration angle when the drug is administered into the drug storage bag 2.
As a more preferable embodiment, the periphery of the slow release tube 3 may be optionally sleeved with a slow release positioning film sleeve (not shown in the figure), the slow release positioning film sleeve outside the through hole can prevent the liquid medicine in the slow release tube 3 from seeping out, and the through hole can allow the liquid medicine in the slow release tube 3 to seep out, so that the liquid medicine seeping out from the slow release tube 3 can be positioned, and the slow release positioning film sleeve is suitable for the situation that the continuous administration is required for some point-like focuses.
It is readily understood by a person skilled in the art that the advantageous ways described above can be freely combined, superimposed without conflict.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011183369.2A CN112244957A (en) | 2020-10-29 | 2020-10-29 | Continuous sustained release drug delivery catheter with puncture sheath |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011183369.2A CN112244957A (en) | 2020-10-29 | 2020-10-29 | Continuous sustained release drug delivery catheter with puncture sheath |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112244957A true CN112244957A (en) | 2021-01-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011183369.2A Pending CN112244957A (en) | 2020-10-29 | 2020-10-29 | Continuous sustained release drug delivery catheter with puncture sheath |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112244957A (en) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204274582U (en) * | 2014-07-01 | 2015-04-22 | 华中科技大学同济医学院附属同济医院 | Separable cannula puncture needle |
| CN105167862A (en) * | 2015-09-28 | 2015-12-23 | 山东航维骨科医疗器械股份有限公司 | Split guide sleeve |
| CN206381223U (en) * | 2016-10-14 | 2017-08-08 | 核工业总医院 | Manadesma blocks ultrasonic puncture pin |
| CN206508016U (en) * | 2016-10-19 | 2017-09-22 | 芜湖市第二人民医院 | A kind of multi-functional PICC punctures sheath |
| CN108653870A (en) * | 2017-03-28 | 2018-10-16 | B.布劳恩梅尔松根股份公司 | Medical pump installation |
| CN108837283A (en) * | 2018-04-12 | 2018-11-20 | 上海市东方医院 | Stem bronchi cell precise positioning slow-released system |
| CN208372266U (en) * | 2017-09-04 | 2019-01-15 | 陆志成 | Catheter is administered in prostate |
| CN109481810A (en) * | 2018-12-18 | 2019-03-19 | 柳兆芳 | A kind of continuous controlled release drug administration type tracheal catheter |
| CN208974039U (en) * | 2018-05-11 | 2019-06-14 | 姜文学 | Bone joint infection drug delivery device |
| CN209204392U (en) * | 2018-07-19 | 2019-08-06 | 昆明市延安医院 | A kind of newborn's trachea cannula |
| CN209771078U (en) * | 2018-12-17 | 2019-12-13 | 深圳市擎源医疗器械有限公司 | drug delivery device |
| CN213821653U (en) * | 2020-10-29 | 2021-07-30 | 安徽省立医院(中国科学技术大学附属第一医院) | Continuous slow-release administration indwelling tube with puncture outer sheath and slow-release tube |
-
2020
- 2020-10-29 CN CN202011183369.2A patent/CN112244957A/en active Pending
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204274582U (en) * | 2014-07-01 | 2015-04-22 | 华中科技大学同济医学院附属同济医院 | Separable cannula puncture needle |
| CN105167862A (en) * | 2015-09-28 | 2015-12-23 | 山东航维骨科医疗器械股份有限公司 | Split guide sleeve |
| CN206381223U (en) * | 2016-10-14 | 2017-08-08 | 核工业总医院 | Manadesma blocks ultrasonic puncture pin |
| CN206508016U (en) * | 2016-10-19 | 2017-09-22 | 芜湖市第二人民医院 | A kind of multi-functional PICC punctures sheath |
| CN108653870A (en) * | 2017-03-28 | 2018-10-16 | B.布劳恩梅尔松根股份公司 | Medical pump installation |
| CN208372266U (en) * | 2017-09-04 | 2019-01-15 | 陆志成 | Catheter is administered in prostate |
| CN108837283A (en) * | 2018-04-12 | 2018-11-20 | 上海市东方医院 | Stem bronchi cell precise positioning slow-released system |
| CN208974039U (en) * | 2018-05-11 | 2019-06-14 | 姜文学 | Bone joint infection drug delivery device |
| CN209204392U (en) * | 2018-07-19 | 2019-08-06 | 昆明市延安医院 | A kind of newborn's trachea cannula |
| CN209771078U (en) * | 2018-12-17 | 2019-12-13 | 深圳市擎源医疗器械有限公司 | drug delivery device |
| CN109481810A (en) * | 2018-12-18 | 2019-03-19 | 柳兆芳 | A kind of continuous controlled release drug administration type tracheal catheter |
| CN213821653U (en) * | 2020-10-29 | 2021-07-30 | 安徽省立医院(中国科学技术大学附属第一医院) | Continuous slow-release administration indwelling tube with puncture outer sheath and slow-release tube |
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