CN110412258B - Full-automatic photo-excitation chemical luminescence detector - Google Patents
Full-automatic photo-excitation chemical luminescence detector Download PDFInfo
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- CN110412258B CN110412258B CN201810400851.3A CN201810400851A CN110412258B CN 110412258 B CN110412258 B CN 110412258B CN 201810400851 A CN201810400851 A CN 201810400851A CN 110412258 B CN110412258 B CN 110412258B
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- 239000000126 substance Substances 0.000 title claims abstract description 9
- 230000001443 photoexcitation Effects 0.000 title claims description 7
- 238000004020 luminiscence type Methods 0.000 title claims description 3
- 230000005284 excitation Effects 0.000 claims abstract description 64
- 230000007246 mechanism Effects 0.000 claims abstract description 40
- 238000001514 detection method Methods 0.000 claims abstract description 30
- 230000003287 optical effect Effects 0.000 claims description 34
- 239000003153 chemical reaction reagent Substances 0.000 claims description 23
- 239000007788 liquid Substances 0.000 claims description 17
- 238000009960 carding Methods 0.000 claims description 13
- 230000008105 immune reaction Effects 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000007723 transport mechanism Effects 0.000 claims 1
- 239000002699 waste material Substances 0.000 abstract description 3
- 238000009434 installation Methods 0.000 abstract 3
- 239000000523 sample Substances 0.000 description 39
- 238000007599 discharging Methods 0.000 description 9
- 238000011534 incubation Methods 0.000 description 7
- 238000012546 transfer Methods 0.000 description 6
- 230000009471 action Effects 0.000 description 5
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
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- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
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- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
- G01N33/5304—Reaction vessels, e.g. agglutination plates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Analytical Chemistry (AREA)
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- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses a cup strip conveying module and a light-excited reading module, wherein the cup strip conveying module is used for conveying a cup strip containing a sample to be tested to the light-excited reading module; the light excitation reading module is used for recording light excitation chemical reflection reaction and reading the incubated sample to be detected; the cup strip conveying module comprises a cup strip transferring mechanism and cup strip installation seats, wherein the cup strip installation seats are arranged on two sides of the cup strip transferring mechanism, and the cup strip installation seats are arranged in the area of the light-activated reading module. The full-automatic light-activated chemiluminescence detector disclosed by the invention adopts the cup strip conveying module to convey the cup strips bearing the reaction cups, so that the traditional plate-type cup strips are abandoned, the resource waste is reduced, the detection period is shortened, the cup strips can be simply and effectively conveyed to the light-activated reading unit, the cost is reduced, and the structure is simplified.
Description
Technical Field
The invention relates to the technical field of chemiluminescence immunoassay, in particular to a full-automatic photo-excitation chemiluminescence detector.
Background
Immunological detection is based on the principle of antigen-antibody specific reaction, and is often used for detecting trace amounts of bioactive substances such as proteins and hormones, because it can display a test substance or amplify a signal by using an isotope, an enzyme, a chemiluminescent substance, or the like.
Chemiluminescent immunoassay is a non-radioactive immunoassay technology which has been rapidly developed in recent years, and the principle is that a chemiluminescent substance is utilized to amplify a signal, and the immunological binding process is directly measured by means of the luminous intensity of the chemiluminescent substance, so that the method has become one of important directions of immunological detection. However, most of cup strips used in the existing light-activated chemiluminescence detectors are plate-type, so that the time difference between the sample in the first detected reaction cup and the sample detected last is large, and the detection accuracy is affected. And the micropore plate has larger volume and is not easy to discard after detection is completed. And the cup strip conveying unit of the traditional light excitation chemiluminescence detector needs to adopt a plurality of pushing mechanisms or a plurality of mechanical arms to finish conveying of the cup strips among the mechanisms, and has a complex structure and high cost.
Disclosure of Invention
Aiming at the technical problems in the prior art, the invention provides a full-automatic photo-excitation chemiluminescence detector, which comprises:
the light laser reading module is used for carrying out laser irradiation on the sample to be measured and reading;
the cup strip conveying module is used for conveying the cup strips containing the samples to be tested to the light-excited reading module;
The cup strip conveying module comprises a cup strip transferring mechanism and a cup strip mounting seat, wherein the cup strip mounting seat is arranged on two sides of the cup strip transferring mechanism, and the cup strip mounting seat is arranged in the area of the light-excited reading module.
In one embodiment, the cup strip transport module further comprises a frame comprising a base plate and a cross beam; the cup strip mounting seats are arranged on the base plates at two sides of the cross beam and are parallel to each other; the cup strip can be accommodated in the cup strip mounting seat.
In one embodiment, the cup strip transfer mechanism comprises:
the first sliding device can slide along the cross beam, and a groove for accommodating the cup strip is formed in the bottom of the first sliding device;
the second sliding device is arranged on the first sliding device and can slide along the direction perpendicular to the cross beam;
The lifting device is arranged on the second sliding device, and can be abutted in the cup strip when descending, so that the cup strip is driven to slide along with the second sliding device.
In one embodiment, two ends of the cup bar are provided with accommodating grooves, and the bottom of the lifting device can be abutted in the accommodating grooves so as to drive the cup bar to move.
In one embodiment, the optical laser reading module comprises:
an excitation unit for emitting excitation light;
The detection unit is used for receiving the optical signals emitted by the excited sample to be detected and collecting and processing the received optical signals;
And the light path component is used for guiding the optical signal generated after the sample to be detected is excited into the detection unit.
In one embodiment, the optical laser reading module comprises:
A bottom plate;
The third sliding device is arranged on the bottom plate and used for driving the cup strips to slide along the first direction;
the fourth sliding device is arranged on the third sliding device and is used for driving the cup strip to slide along the second direction;
The optical path detection mechanism is used for carrying out light excitation detection on the sample to be detected.
In one embodiment, the bottom plate is provided with a cup strip dropping groove.
In one embodiment, a cuvette sorter is also included for aligning the cuvettes and feeding the cuvettes into the cuvette stacking mechanism.
In one embodiment, the cup arranging device comprises a cup leaking device and a cup arranging device, wherein the cup arranging device is arranged below the cup leaking device, the cup leaking device can enable reaction cups to fall into the cup arranging device in a controllable manner, and the cup arranging device is used for arranging and arranging the reaction cups.
In one embodiment, the leak cup apparatus includes:
The bottom of the cup bin is provided with a cup leakage opening;
And the carding part is arranged at the cup leakage opening and is used for carding the reaction cup at the cup leakage opening so as to control the dropping rate of the reaction cup.
In one embodiment, the cup holder is configured as an inverted pyramid.
In one embodiment, the carding part comprises a base and a wheel shaft arranged on the base, a brush capable of extending into the cup leakage opening is arranged on the wheel shaft, and the wheel shaft can drive the brush to rotate so as to comb the reaction cup at the cup leakage opening, so that the dropping rate of the reaction cup is controlled.
In one embodiment, the cup discharging device comprises a centrifugal mechanism and a cup discharging channel, wherein the centrifugal mechanism is used for centrifugally treating the reaction cups falling into the cup leaking device, the centrifugal mechanism is provided with a discharge outlet, the reaction cups centrifugally treated by the centrifugal mechanism enter the cup discharging channel from the discharge outlet, a limiting part is arranged at the inlet of the cup discharging channel, the limiting part enables the reaction cups to enter the cup discharging channel in a lying posture, and the cup discharging channel is used for vertically arranging the reaction cups.
In one embodiment, the fully automated light activated chemiluminescent detector further comprises an incubator for providing a suitable ambient temperature for the chemiluminescent immune reaction.
In one embodiment, the fully automatic light activated chemiluminescent detector further comprises a universal liquid loading module for adding universal liquid to the reaction cup.
In one embodiment, the full-automatic light excitation chemiluminescence detector comprises a cup strip conveying module, a light excitation reading module, a sample carrier, a cup arranging device, an incubator, a sample adding module, a reagent refrigerating disc, a universal liquid loading module and a cup discarding frame, wherein the full-automatic light excitation chemiluminescence detector is of an upper and lower double-layer structure, the cup discarding frame is arranged below the light excitation reading module, the reagent refrigerating disc is arranged below the reagent adding module, the sample carrier is arranged below the sample adding module, the cup arranging device is arranged at a position close to the front end of the cup strip conveying module, and the universal liquid loading module is arranged at a position close to the incubator.
Compared with the prior art, the full-automatic light excitation chemiluminescence detector disclosed by the invention has the advantages that the cup strip conveying module is adopted to convey the cup strip bearing the reaction cup, so that the traditional plate-type cup strip is abandoned, the resource waste is reduced, the detection period is shortened, the cup strip can be simply and effectively conveyed to the light excitation reading unit, the cost is reduced, and the structure is simplified.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.
Drawings
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings. In the figure:
fig. 1 is a schematic structural diagram of a fully automatic photo-activated chemiluminescent detector according to the present invention.
Fig. 2 is a schematic view of the cup strip transfer mechanism of fig. 1.
Fig. 3 is a schematic view of the structure of a cup strip according to the present invention.
Fig. 4 is a schematic diagram of the structure of the optical laser reading module according to the present invention.
Fig. 5 is a side view of fig. 4.
Fig. 6 is a schematic diagram of the structure of the receiving optical switch in fig. 4.
Fig. 7 is a schematic diagram of a structure of a laser reading module according to the present invention.
Fig. 8 is a front view of a laser reading module according to the present invention.
Fig. 9 is a top view of a laser reading module according to the present invention.
Fig. 10 is a schematic structural view of the cup organizer according to the present invention.
Reference numerals: 1-a cup strip conveying module; 11-a frame; 111-a substrate; 112-a cross beam; 12-a cup bar mounting seat; 13-cup strips; 131-a receiving groove; 132-cup hole; 14-a cup strip transfer mechanism; 141-a first slide; 1411-a base; 1412-grooves; 142-a second slide; 143-lifting device; 2-a light excitation reading module; 221-an excitation unit; 222-a detection unit; 223-optical path component; 224-excitation light switch; 2241-rotating part; 2242-through holes; 225-receiving an optical switch; 2251-a baffle; 2252—a first circular hole; 2253—a second circular hole; 2254—a first rotation part; 2255-a second rotation part; 226-control means; 227-half-mirror half-lens; 228-a lens; 229-a filter; 230-opening; 21-a bottom plate; 22-a third slide; 23-fourth slide means; 24-an optical path detection mechanism; 25-reaction cup; 26-inlet; 201-horizontal movement guide rail; 202-a vertically moving rail; 203-a moving element; 204-a first fixation element; 211-a transverse moving guide rail; 212-vertically moving guide rails; 213-a second fixing element; 4-cup arranging device; 41-a cup leakage device; 411-cup bin; 412-carding section; 4121-a base; 4122-brush; 42-cup arranging device; 421-centrifugation mechanism; 422-row cup channels; 5-incubator; 6-a sample adding module; 7-a reagent adding module; 8-a reagent refrigeration tray; 9-a universal liquid loading module; 10-discarding the cup frame.
In the drawings, like parts are designated with like reference numerals. The figures are not drawn to scale.
Detailed Description
The following will describe embodiments of the present invention in detail with reference to the drawings and examples, thereby solving the technical problems by applying technical means to the present invention, and realizing the technical effects can be fully understood and implemented accordingly. It should be noted that, as long as no conflict is formed, each embodiment of the present invention and each feature of each embodiment may be combined with each other, and the formed technical solutions are all within the protection scope of the present invention.
Fig. 1 provides a full-automatic photo-excited chemiluminescence detector according to the present invention, as shown in fig. 1, the full-automatic photo-excited chemiluminescence detector includes a cup strip conveying module 1 and a photo-excited reading module 2, the cup strip conveying module 1 is used for conveying a cup strip 13 carrying a reaction cup to the photo-excited reading module 2, a sample to be measured is contained in the reaction cup, and the photo-excited reading module 2 is used for carrying out laser irradiation and reading on the sample to be measured.
The full-automatic light-activated chemiluminescence detector disclosed by the invention adopts the cup strip conveying module to convey the cup strips bearing the reaction cups, so that the traditional plate-type cup strips are abandoned, the resource waste is reduced, the detection period is shortened, the cup strips can be simply and effectively conveyed to the light-activated reading unit, the cost is reduced, and the structure is simplified.
In one embodiment, as shown in fig. 1 and 2, the cup strip conveying module 1 includes a frame 11, a cup strip mounting seat 12, a cup strip 13 and a cup strip transferring mechanism 14, the frame includes a base plate 111 and a beam 112, the cup strip mounting seat 12 is disposed on the base plate 111 at two sides of the beam 112 in parallel, the cup strip 13 can be accommodated in the cup strip mounting seat 12, and the cup strip transferring mechanism 14 is used for conveying the cup strip. The cup strip conveying module 1 adopts a three-dimensional movement mode, so that the cup strip can be simply and effectively conveyed to the light-activated reading unit, the cost is reduced, and the structure is simplified.
In one embodiment, as shown in FIG. 2, the cup strip transfer mechanism 14 includes a first slide 141, a second slide 142, and a lift 143. The first sliding device 141 can slide along the beam 112, and the base 1411 of the first sliding device 141 has a groove 1412 for accommodating the cup bar 13. The second sliding means 142 is provided on the first sliding means 141, and the second sliding means 142 is capable of sliding in a direction perpendicular to the beam 112. The lifting device 143 is disposed on the second sliding device 142, and when the lifting device 143 descends, the lifting device 143 can abut against the cup strip 13, so as to drive the cup strip 13 to slide along with the second sliding device 142. As shown in fig. 3, the cup strip 13 has cup holes 132 for accommodating reaction cups, the number of the cup holes 132 can be set according to actual needs, two ends of the cup strip 13 have accommodating grooves 131, and the movable iron core of the lifting device 143 can be abutted in the accommodating grooves 131, so as to drive the cup strip 13 to move.
The first sliding device 141 and the second sliding device 142 may adopt a common sliding rail and slider structure, which is not described herein. The lifting device 143 adopts a common electromagnetic switch, the movable iron core of the electromagnetic switch is in a vertical direction, and the movable iron core can be accommodated in the accommodating groove 131 of the cup bar.
In one embodiment, as shown in fig. 4, the optical laser reading module 2 includes an excitation unit 221, a detection unit 222, and an optical path component 223. The excitation unit 221 is for emitting excitation light. The detection unit 222 is configured to receive an optical signal emitted by the excited sample to be detected, and collect and process the received optical signal. The light path component 223 is used for guiding the optical signal generated after the sample to be tested is excited into the detection unit.
In one embodiment, the excitation unit 221 includes an exciter capable of emitting 600-700 nm red excitation light.
In a preferred embodiment, the excitation unit 221 comprises, in addition to an exciter, an excitation light switch 224 for controlling the on and off of the excitation light emitted by the excitation unit 201.
In one embodiment, as shown in fig. 5, the excitation light switch 224 includes a rotating part 2241, and two through holes 2242 are formed on a sidewall of the rotating part 2241, and the two through holes 2242 pass through an axis of the rotating part 2241. When the line connecting the two through holes 2242 is vertical, the excitation light switch 224 is in an on state, the excitation light is turned on, and the excitation light can be irradiated onto the sample to be measured located below the opening 230 through the through holes 2242. When the line connecting the two through holes 2242 is not vertical, the excitation light switch 224 is in the off state, the excitation light is blocked, and the excitation light cannot irradiate the sample to be measured located below the opening 230.
In one embodiment, the detection unit 222 includes a detector selected from one of a single photon counter, a photomultiplier tube, a silicon photocell, or a photometric integrating sphere.
In a preferred embodiment, the detection unit 222 includes, in addition to the detector, a receiving optical switch 225, where the receiving optical switch 225 is used to control the on or off of an optical signal generated after the sample to be tested is excited.
In one embodiment, as shown in fig. 6, the light receiving switch 225 includes a baffle 2251 and a crank rocker mechanism, and a first circular hole 2252 is provided at a lower portion of the baffle 2251; the lower part of the crank-rocker mechanism is provided with a second circular hole 2253, the movement of the crank-rocker mechanism enables the first circular hole 2252 and the second circular hole 2253 to coincide with each other, when the first circular hole 2252 and the second circular hole 2253 coincide with each other, the light receiving switch 225 is turned on, and when the first circular hole 2252 and the second circular hole 2253 do not coincide, the light receiving switch 225 is turned off.
In this embodiment, the crank and rocker mechanism includes a first rotary part 2254 and a second rotary part 2255, the first rotary part 2254 being fixedly disposed on the baffle 2251; the second rotating portion 2255 is rotatably connected to the first rotating portion 2254, and a second circular hole 2253 is provided at a lower portion of the second rotating portion 2255. The first rotating part 2254 is driven by the driving device to rotate, and drives the second rotating part 2255 to rotate, so that when the second circular hole 2253 rotates to a position corresponding to the first circular hole 2252, the first circular hole 2252 and the second circular hole 2253 overlap each other.
In one embodiment, as shown in fig. 4, the excitation light switch 224 and the receiving light switch 225 are both connected to the control device 226, and the control device 226 is configured to turn off the receiving light switch 225 when the excitation light switch 224 is turned on, and turn off the excitation light switch 224 when the receiving light switch 225 is turned on. Preferably, the control device 226 is a driver, one end of the driver is connected to the excitation light switch 224, and the other end is connected to the receiving light switch 225, so that the excitation light switch 224 and the receiving light switch 225 cannot be simultaneously turned on no matter how the driver is turned.
In one embodiment, as shown in fig. 4, the optical path assembly 223 includes a half-mirror 227, a lens 228, and a filter 229 sequentially disposed along the direction of the received light, and the half-mirror 227 is disposed at the intersection of the excitation light path and the receiving light path. The half-reflecting half lens 227 can not only cut off excitation light of non-target wavelength by excitation light of target wavelength, but also reflect a light-emitting signal of target wavelength generated by a sample to be measured. Preferably, the half reflecting half mirror is obliquely arranged at an angle of 45 degrees at the junction of the excitation light and the receiving light. The optical signal generated by the sample to be measured and reflected by the half-reflecting half-lens 227 enters the detection unit 222 through the lens.
In another embodiment, as shown in fig. 7, the optical laser reading module 2 includes a base plate 21, a third slider 22, a fourth slider 23, and an optical path detecting mechanism 24. The third sliding device 22 is disposed on the bottom plate 21 and is used for driving the cup bar 13 to slide along a first direction, in this embodiment, a direction perpendicular to the beam 112, and a second direction parallel to the beam 112. When the first sliding device 141 drives the cup bar 13 to move along the beam 112 to approach the light-induced polarization reading module 2, the second sliding device 142 pushes the cup bar to enter the transfer channel through the inlet 26 of the light-induced polarization reading module 2, the fourth sliding device 23 located at the transfer channel slides forward to engage the cup bar 13, and then the third sliding device 22 drives the reaction cup 25 to move below the light path detecting mechanism 24 to perform light-induced polarization reading on the sample to be measured in the reaction cup 25. In addition, a cup strip dropping groove is formed in one side, away from the inlet 26, of the bottom plate 21, after the cup strip 13 is detected, the third sliding device 22 and the fourth sliding device 23 drive the cup strip 13 to move to the position of the cup strip dropping groove, and after the fourth sliding device 23 releases the cup strip 13, the cup strip 13 drops from the dropping groove.
Preferably, as shown in fig. 8, the optical laser reading module 2 may be configured as follows: comprises a horizontal moving guide rail 201 and a vertical moving guide rail 202, wherein the horizontal moving guide rail 201 and the vertical moving guide rail 202 form a closed loop. The horizontal moving rail 201 in this embodiment includes two horizontal moving rails parallel to each other up and down, and the horizontal movement track of the moving element 203 passes under the light path detection probe, so that the cuvette can move to the position under the light path detection mechanism for detection. The moving element 203 has a unit for fixing the cup bar, and may be provided as a tab or a claw, for example.
The vertical moving rail 202 in this embodiment includes left and right two vertical moving rails parallel to each other. The vertical moving rail 202 is used for driving the moving element 203 to move up and down. The two vertical moving rails 202 are respectively provided with a first fixing element 204, and the first fixing element 204 is used for fixing the moving element 203 and driving the moving element 203 to move up and down along the vertical moving rails 202. The first fixing element 204 is provided with a sensor, when the moving element 203 completely enters the first fixing element 204, the sensor sends out a signal, and the detector starts the lifting action to drive the moving element 203 to move up and down.
Specifically, when the cup strip moves under the drive of the moving element 203 to the position right below the light path detection probe, the detected cup strip continues to move horizontally under the drive of the moving element 203, when the cup strip is far away from the light path detection mechanism and reaches the position of the vertical moving guide rail 202, the first fixing element 204 drives the moving element to descend to the position B, and performs cup discarding action at the position B, after discarding the cup, the moving element 203 breaks away from the first fixing element 204 and moves to the position of the vertical moving guide rail C at the other side along the horizontal moving guide rail, when the moving element 203 completely enters the first fixing element 204 on the vertical moving guide rail 202, a signal is sent by a sensor on the first fixing element 204, the detector starts to act, and the moving element ascends to the position of the horizontal moving guide rail A at the upper layer along the vertical moving guide rail 202, and drives the next batch of cup strips to repeat the action at the position A. Meanwhile, a plurality of moving elements can be operated, and the sample injection at the port A can be realized (the influence of light leakage on the reading is avoided) as long as the optical laser reading is ensured.
In another preferred embodiment, as shown in fig. 9, the optical laser reading module 2 may be constructed as follows: comprising two mutually parallel transverse moving rails 211 and two mutually parallel vertical moving rails 212, the transverse moving rails 211 and the vertical moving rails 212 forming a closed loop parallel to the horizontal plane.
One of the lateral movement rails 211 is provided directly under the optical path detecting probe so that the cup bar can be moved to the directly under the optical path detecting mechanism 24 for detection. The moving element has a unit for fixing the cup strip, which can be embodied as a tab or as a claw or the like.
The two vertical moving rails 212 are respectively provided with a second fixing element 213, and the second fixing element 213 is used for fixing the moving element 203 and driving the moving element 203 to move along the vertical moving rails 212. The second fixing element 213 is provided with a sensor, and when the moving element 203 completely enters the second fixing element 213, the sensor sends out a signal, and the detector starts to act to drive the moving element to move vertically.
Specifically, referring to fig. 9, when the cup bar is driven by the moving element 203 to move directly under the optical path detecting probe, the detected cup bar continues to move transversely under the driving of the moving element, when the detected cup bar is far away from the optical path detecting mechanism 24 to the position of the vertical moving guide rail 212, the moving element enters the second fixing element 213, the second fixing element 213 drives the moving element 203 to move to the position D, the cup discarding action is performed at the position D, after the cup discarding, the moving element 203 is separated from the second fixing element 213, and when the detected cup bar moves transversely to the position E, the next batch of cup bars are driven to repeat the above actions. Meanwhile, a plurality of moving elements can be operated, and the E port can be used for sample injection without sample injection (avoiding light leakage to influence the reading) as long as the optical laser reading is ensured.
In one embodiment, as shown in fig. 10, the fully automatic photo-activated chemiluminescent detector further comprises a cuvette sorter 4 for aligning the cuvettes.
In one embodiment, the cup arranging device 4 comprises a cup leaking device 41 and a cup arranging device 42, wherein the cup arranging device 42 is arranged below the cup leaking device 41, the cup leaking device 41 can enable reaction cups to fall into the cup arranging device 42 in a controllable manner, and the cup arranging device 42 is used for arranging the reaction cups vertically.
In one embodiment, the leak cup assembly 41 includes a cup holder 411 and a comb portion 412. The bottom of the cup bin 411 is provided with a cup leakage opening, and the carding part 412 is arranged at the cup leakage opening and used for carding the reaction cup at the cup leakage opening so as to control the dropping rate of the reaction cup. Preferably, the cup compartment 411 is constructed in an inverted quadrangular pyramid shape, and has a large upper opening area and a small opening area at the mouth of the leakage cup.
In one embodiment, the carding part 412 comprises a base 4121 and a wheel shaft arranged on the base 4121, wherein a brush 4122 capable of extending into the cup leakage opening is sleeved on the wheel shaft, and the wheel shaft can drive the brush 4122 to rotate, so that the reaction cup can controllably fall into the cup arranging device 42 under the carding of the brush. In the embodiment shown in fig. 5, the carding unit 412 has two shafts, and the brushes 4122 are mounted on the two shafts, and the rotation directions of the two shafts are rotated inwards, so that the brushes sleeved on the two shafts are rotated inwards to match the carding reaction cup.
In one embodiment the cup alignment device 42 includes a centrifugal mechanism 421 and a cup alignment channel 422. The reaction cup dropped from the cuvette assembly 41 is subjected to the centrifugal process of the centrifugal mechanism 421 so that the reaction cup is dispersed without being piled up in one place. The centrifugal mechanism 421 has a discharge port having an opening width not greater than the length of one cuvette so that the cuvette can slide out therefrom. The reaction cup sliding out from the discharge port enters the cup discharging channel 422, and the inlet of the cup discharging channel 422 is provided with a limiting part, so that the reaction cup can only enter the cup discharging channel 422 in a lying posture. Three conveyor belts arranged in parallel are arranged in the cup arranging channel 422, the length of the middle conveyor belt is short, the width of the middle conveyor belt is larger than the width of the cup body and smaller than the width of the cup head, so that the position where the middle conveyor belt ends and the two conveyor belts on two sides form a cup arranging groove, when the lying reaction cup passes through the cup arranging groove, the reaction cup is arranged in an upright posture again, and finally the reaction cup is conveyed to the tail end of the cup arranging channel in an upright posture.
In one embodiment, as shown in FIG. 1, the fully automated photo-activated chemiluminescent detector further comprises an incubator 5 for providing a suitable ambient temperature for the chemiluminescent immune reaction. In this embodiment, the incubator 5 is provided at one side of the cup strip transport module 1, and a cup strip 13 mount 12 for placing a cup strip is provided in the incubator 5. After the sample to be measured is prepared, the cup strip conveying module 1 conveys the cup strips to the cup strip mounting seat 12 in the incubator 5 for incubation.
Preferably, the incubator 5 comprises a first incubation unit and a second incubation unit. The universal liquid loading module adds universal liquid to the reaction cups within the strips during movement of the strips from the first incubation unit to the second incubation unit.
In an embodiment, as shown in fig. 1, the fully automatic photo-activated chemiluminescence detector further comprises a sampling module 6, and in this embodiment, the sampling module 6 is disposed near the front end of the cup strip conveying module 1. The cup strip conveying module 1 conveys the cup strip carrying the reaction cup to the sample adding module 6 for adding the sample.
In an embodiment, as shown in fig. 1, the fully automatic photo-activated chemiluminescence detector further comprises a reagent adding module 7, and in this embodiment, the reagent adding module 7 is disposed close to the sample adding module 6. The cup strip added with the sample is separated from the sample adding module 6 under the drive of the cup strip conveying module 1 and moves to the reagent adding module 7 for adding the reaction reagent.
In one embodiment, as shown in fig. 1, the fully automatic photoexcitation chemiluminescent detector further includes a reagent cooling tray 8, in which a reagent is contained. In this embodiment, a reagent chill plate is provided below the reagent addition module 7 to facilitate the mechanical sample addition arm to draw reagent from the reagent chill plate 8 and add it to the strips.
In one embodiment, as shown in fig. 1, the fully automatic photo-activated chemiluminescence detector further comprises a universal liquid loading module 9. In this embodiment, a universal liquid loading module 9 is provided near the incubator 5 to add universal liquid as the strips are moved from the first incubation unit to the second incubation unit.
In an embodiment, as shown in fig. 1, the fully automatic light excitation chemiluminescence detector further comprises a cup discarding frame 10, and in this embodiment, the cup discarding frame 10 is disposed below the light excitation reading module 2 and is used for accommodating a cup strip discarded after light excitation reading.
In one embodiment, as shown in fig. 1, the fully automatic light excitation chemiluminescence detector comprises a cup strip conveying module 1, a light excitation reading module 2, a sample carrier (not shown in the figure), a cup arranging device 4, an incubator 5, a sample adding module 6, a reagent adding module 7, a reagent refrigerating tray 8, a universal liquid loading module 9 and a cup discarding frame 10. In this embodiment, the detector is constructed as a double-layer structure from top to bottom, the cup frame 10 is disposed below the light excitation reading module 2, the reagent refrigerating tray 8 is disposed below the reagent adding module 7, the sample carrier is disposed below the sample adding module 6, the cup sorter 4 is disposed at a position close to the front end of the cup strip conveying module 1, the universal liquid loading module 9 is disposed at a position close to the incubator 5, and in the upper-layer structure, each module is disposed at two sides of the cup strip conveying module 1, so as to facilitate conveying of the cup strips between each module. The upper layer and the lower layer are designed, the size of the instrument can be shortened, and the cooperation among all the parts is more compact and smooth, so that the detection efficiency is further improved.
The above description is merely a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily make modifications or variations within the technical scope of the present invention disclosed herein, and such modifications or variations are intended to be included in the scope of the present invention. Therefore, the protection scope of the invention is subject to the protection scope of the claims.
Claims (15)
1. A fully automatic photo-activated chemiluminescence detector, comprising:
The light laser reading module is used for carrying out laser irradiation on the sample to be measured and reading; the light excitation reading module comprises an excitation unit for emitting excitation light; the excitation unit comprises an excitation light switch, and the excitation light switch is used for controlling the conduction and the blocking of excitation light emitted by the excitation unit; the excitation light switch comprises a rotating part, wherein two through holes are formed in the side wall of the rotating part, and the two through holes penetrate through the axis of the rotating part; when the connecting line of the two through holes is vertical, the excitation light switch is in an open state, and excitation light is conducted; when the connecting line of the two through holes is not vertical, the excitation light switch is in a closed state, and the excitation light is blocked;
the cup strip conveying module is used for conveying the cup strips containing the samples to be tested to the light-excited reading module;
The cup strip conveying module comprises a cup strip transferring mechanism and cup strip mounting seats, wherein the cup strip mounting seats are arranged on two sides of the cup strip transferring mechanism, and the cup strip mounting seats are arranged in the area of the light-excited reading module;
The full-automatic photo-excitation chemical luminescence detector comprises a sample carrier, a cup sorter, an incubator, a sample adding module, a reagent refrigerating disc, a universal liquid loading module and a cup discarding frame;
The full-automatic light excitation chemiluminescence detector is constructed into an upper layer structure and a lower layer structure, the cup discarding frame is arranged below the light excitation reading module, the reagent refrigerating tray is arranged below the reagent adding module, the sample carrier is arranged below the sample adding module, the cup arranging device is arranged at a position close to the front end of the cup strip conveying module, and the universal liquid loading module is arranged at a position close to the incubator; in the upper layer structure, the light excitation reading module, the universal liquid loading module, the reagent adding module, the incubator and the sample adding module are arranged on two sides of the cup strip conveying module.
2. The fully automatic light activated chemiluminescent detector of claim 1 wherein the cup strip transport module further comprises a rack comprising a base plate and a cross beam; the cup strip mounting seats are arranged on the base plates at two sides of the cross beam and are parallel to each other; the cup strip can be accommodated in the cup strip mounting seat.
3. The fully automatic light activated chemiluminescent detector of claim 2 wherein the cup strip transport mechanism comprises:
the first sliding device can slide along the cross beam, and a groove for accommodating the cup strip is formed in the bottom of the first sliding device;
a second sliding device provided on the first sliding device, the second sliding device being capable of sliding in a direction perpendicular to the cross beam;
The lifting device is arranged on the second sliding device, and can be abutted in the cup strip when descending, so that the cup strip is driven to slide along with the second sliding device.
4. The full-automatic light-activated chemiluminescence detector of claim 3, wherein two ends of the cup bar are provided with accommodating grooves, and the bottom of the lifting device can be abutted in the accommodating grooves so as to drive the cup bar to move.
5. The fully automatic light activated chemiluminescent detector of claim 1 wherein the light activated readout module comprises:
an excitation unit for emitting excitation light;
The detection unit is used for receiving the optical signals emitted by the excited sample to be detected and collecting and processing the received optical signals;
And the light path component is used for guiding the optical signal generated after the sample to be detected is excited into the detection unit.
6. The fully automatic light activated chemiluminescent detector of claim 2 wherein the light activated readout module comprises:
A bottom plate;
the third sliding device is arranged on the bottom plate and used for driving the cup strips to slide along a first direction, and the first direction is a direction perpendicular to the cross beam;
the fourth sliding device is arranged on the third sliding device and is used for driving the cup strips to slide along a second direction, and the second direction is a direction parallel to the cross beam;
The optical path detection mechanism is used for carrying out light excitation detection on the sample to be detected.
7. The fully automatic light activated chemiluminescent detector of claim 6 wherein the base plate is provided with a cup strip drop well.
8. The fully automatic light activated chemiluminescent apparatus of claim 1 further comprising a cup organizer for upright alignment of reaction cups.
9. The fully automatic light activated chemiluminescent apparatus of claim 8 wherein the cup organizer comprises a cup drain and a cup row, the cup row being disposed below the cup drain, the cup drain being capable of allowing reaction cups to controllably fall into the cup row, the cup row being for arranging the reaction cups.
10. The fully automatic photo-activated chemiluminescent detector of claim 9 wherein the cuvette assembly comprises:
The bottom of the cup bin is provided with a cup leakage opening;
And the carding part is arranged at the cup leakage opening and is used for carding the reaction cup at the cup leakage opening so as to control the dropping rate of the reaction cup.
11. The fully automatic light activated chemiluminescent detector of claim 10 wherein the cup holder is configured as an inverted pyramid.
12. The full-automatic light-activated chemiluminescence detector of claim 10, wherein the carding portion comprises a base and a wheel shaft arranged on the base, a brush capable of extending into the cup leakage opening is arranged on the wheel shaft, and the wheel shaft can drive the brush to rotate so as to card the reaction cup at the cup leakage opening to control the dropping rate of the reaction cup.
13. The full-automatic photoexcitation chemiluminescent apparatus of claim 9 wherein the cup discharge device comprises a centrifugal mechanism and a cup discharge channel, the centrifugal mechanism is used for centrifuging reaction cups falling from the cup discharge device, the centrifugal mechanism is provided with a discharge outlet, the reaction cups centrifugally processed by the centrifugal mechanism enter the cup discharge channel from the discharge outlet, a limit part is arranged at an inlet of the cup discharge channel, the limit part enables the reaction cups to enter the cup discharge channel in a lying posture, and the cup discharge channel is used for vertically arranging the reaction cups.
14. The fully automated light activated chemiluminescent detector of claim 1 further comprising an incubator for providing a suitable ambient temperature for the chemiluminescent immune reaction.
15. The fully automatic light activated chemiluminescent detector of claim 1 further comprising a universal liquid loading module for adding universal liquid to the cuvette.
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| CN114324914A (en) * | 2020-09-29 | 2022-04-12 | 基蛋生物科技股份有限公司 | A multi-display board reagent strip carrier system and medical equipment |
| CN115963286B (en) * | 2022-12-26 | 2023-10-10 | 广州市进德生物科技有限公司 | Multifunctional luminous reading station capable of continuously detecting |
| CN116297416B (en) * | 2023-05-22 | 2023-11-10 | 科美诊断技术股份有限公司 | Photo-excitation chemiluminescence detection device and detection method |
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