CN109303743B - 中药组合物在制备护肤品中的应用 - Google Patents
中药组合物在制备护肤品中的应用 Download PDFInfo
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- CN109303743B CN109303743B CN201811394262.5A CN201811394262A CN109303743B CN 109303743 B CN109303743 B CN 109303743B CN 201811394262 A CN201811394262 A CN 201811394262A CN 109303743 B CN109303743 B CN 109303743B
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Abstract
本发明公开了中药组合物在制备护肤品中的应用，涉及口腔护理技术领域，即在制备护肤品的工艺中将复方中药提取物作为消炎抑菌作用的唯一活性成分加入护肤品中，所述复方中药提取物为断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物，其质量比为2:5:2:2:3:2:3:2:2:1:1，本中药组合物不仅使用安全，而且具有清热消炎抑菌功效，不仅缓解疮疹，抗过敏，凉血、消炎、抑菌菌，同时降低产品的刺激性，不易引起皮肤微生态环境失衡，对皮肤具有调节和保护作用，以及安全有效，可以日常使用，制作简便。
Description
技术领域
本发明涉及洗护用品技术领域，尤其是一种具有清热凉血除菌功效的护肤品。
背景技术
随着生活水平的不断提高，人们越来越注重自身皮肤的保养，护肤品已成为每个家庭的必需品。特别对于广大女性消费者，护肤品之所以能够保养皮肤是因为其中含有大量的营养成分，但当人们的皮肤上涂有护肤品时就更容易滋生细菌，而细菌的生长很容易造成皮炎和皮肤过敏；另外护肤品中的化学原料也可能因为长时间接触皮肤引起过敏症状。虽然现在的护肤品中都含有一定量的防腐剂，但是这些只能保证未开封使用的产品质量，而且防腐剂本身对皮肤有很大的刺激性和致敏性。后来，人们经过研究、改进，在护肤品中添加各种中草药，以达到消炎、抗过敏的目的；但很多护肤品的中草药搭配不合理或者选择不当，消炎、抗过敏效果并不明显。
发明内容
本发明解决的问题是提供中药组合物在制备护肤品中的应用方案，这种护肤品具有明显的消炎、抑菌作用。
本发明的中药组合物在制备护肤品中的应用方案就是在制备护肤品的工艺中将复方中药提取物作为消炎抑菌作用的唯一活性成分加入护肤品中，所述复方中药提取物为断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物的质量比为2:5:2:2:3:2:3:2:2:1:1。
上述技术方案中，更具体的方案还可以是：所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤水工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在润肤水原料中的重量百分比为10～80％。
进一步的：所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤乳工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在润肤乳原料中的重量百分比为4～40％。
进一步的，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤霜工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在润肤霜原料中的重量百分比为2～20％。
本发明所述的断血流，为唇形科植物灯笼草(Cliruo podium polycephalum(Vani-ot)C.Y.Wu et Hsuan)或风轮菜(Clinopodium chinense(Benth)Q.Kuntze)的干燥地上部分，其提取物具有收敛止血、凉血活血的功效。
本发明所述紫苏叶，为唇形科植物紫苏(Perilla frutescens(L.)Britt.)的叶片部分，其提取物含有桂皮醛和其他酚类、有机酸、苷类等化学成分，具有发汗解肌、温通经脉的效果，且能抑菌、止血、抗氧化等作用。
本发明所述败酱草，为败酱科植物黄花败酱(Patrinia scabiosaefolia Fisch)或白花败酱(Patrinia villosa Juss)的全草部分，其提取物具有清热解毒，祛瘀排脓、清疮止痛等功效,且有抑菌和抗病毒的作用。
本发明所述的青蒿，为菊科植物黄花蒿(Artemisia carvifolia L.)的干燥地上部分，其提取物具有清热凉血、清暑热、截疟的功效；且有很好的抗病原微生物、抗内毒素、抗菌消炎等作用；其挥发油还对皮肤癣有杀灭作用。
本发明所述的肿节风，为金栗兰科草珊瑚(Sarcandra glabra(Thunb.)Nakai)的干燥全草，其提取物具有清热凉血、活血消斑、祛风通络的功效；且有很好的抗菌、抗病毒、抗炎作用。
本发明所述的鸡血藤，为豆科植物密花豆(Spatholobus suberectus Dunn)的干燥根茎，其提取物具有活血补血、调经止痛、舒筋活络的功效；且有有抗炎和调节免疫系统的作用。
本发明所述的黄柏，为芸香科黄皮树(Phellodendron chinense Schneid.)的干燥树皮，其提取物具有清热燥湿、解毒疗疮、泻火除蒸的功效；且有抗病原微生物、抗炎、解热、抗氧化、抗溃疡等作用。
本发明所述的豨莶草，为菊科植物豨莶(Siegesbeckia orientalis L.)、腺梗豨莶(Siegesbeckia pubescens Makino)或毛梗豨莶(Siegesbeckia glabrescens Makino)的干燥地上部分，其提取物具有清热解毒、祛风湿、利关节的功效；且有抗炎、抗疱疹病毒、抗菌的作用。
本发明所述的伸筋草，为石松科植物石松(Lycopodium jaPonicum Thunb.)的干燥全草，其提取物具有祛风除湿、舒筋活络的功效；且有抑菌、抗炎、镇痛、抗氧化的作用。
本发明所述的肉桂，为樟科植物肉桂(Cinnamomum cassia Presl)的干燥树皮，其提取物具有补火助阳、引火归元、散寒止痛、温通经脉的功效；且有解热、镇痛的作用。
本发明所述的生姜，为姜科植物姜(Zingiber officinale Rosc.)的新鲜根茎，其提取物具有发汗解表的功效；且具有很好的抗炎、解热、抗菌镇痛、抗溃疡等作用。
本发明中药的提取方法为：所述中药提取物采用乙醇提取，按得到中药提取物：混合原药材＝1:2—1:5的质量比例提取。
本发明的护肤品产品制备过程中加入了上述中药组合物作为活性成分，具有清热消炎抑菌功效，不仅缓解疮疹，抗过敏，凉血、消炎、抑菌，同时降低产品的刺激性，不易引起皮肤微生态环境失衡，对皮肤具有调节和保护作用，以及安全有效，可以日常使用，制作简便。
具体实施方式
下面结合实施例，对本发明做进一步说明，下列各实施例中，所涉及的百分比除非另有说明，均是以重量百分比计算。
实施例1至实施例6中的润肤水组成原料及重量百分比含量如表1：
下列各实施例中，中药消炎抑菌成分中，各中药提取物为断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤水工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物，实施例1中，各中药提取物的比例为：0:0:0:0:0:0:0:0:0:0:0；实施例2～4中，各中药提取物的比例按上述顺序为：2:5:2:2:3:2:3:2:2:1:1；实施例5中，各中药提取物的比例按上述顺序为：2:5:2:2:3:2:0:2:0:1:1；实施例6中，各中药提取物的比例按上述顺序为：2:5:2:2:0:0:3:2:2:1:1；
表1：
实施例7至实施例12中的润肤乳组成原料及重量百分比含量如表2：
下列各实施例中，中药消炎止痒成分中各中药提取物为血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备香皂工艺中作为消炎止痒作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物，实施例7中，各中药提取物的比例为：0:0:0:0:0:0:0:0:0:0:0；实施例8～10中，各中药提取物的比例按上述顺序为：2:5:2:2:3:2:3:2:2:1:1；实施例11中，各中药提取物的比例按上述顺序为：2:5:2:2:3:2:0:2:0:1:1；实施例12中，各中药提取物的比例按上述顺序为：2:5:2:2:0:0:3:2:2:1:1；
表2：
实施例13至实施例18中的润肤霜组成原料及重量百分比含量如表3：
下列各实施例中，中药消炎止痒成分中各中药提取物为血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备香皂工艺中作为消炎止痒作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物，实施例13中，各中药提取物的比例为：0:0:0:0:0:0:0:0:0:0:0；实施例14～16中，各中药提取物的比例按上述顺序为：2:5:2:2:3:2:3:2:2:1:1；实施例17中，各中药提取物的比例按上述顺序为：2:5:2:2:3:2:0:2:0:1:1；实施例18中，各中药提取物的比例按上述顺序为：2:5:2:2:0:0:3:2:2:1:1；
表3：
临床实验部分：
1、抑菌实验(按《一次性使用卫生用品卫生标准》GB15979中抑菌率方法测试)，结果如表4：
结果表明，实施例2-4、实施例8-10和实施例14-16中，复方中药提取物和用该提取物配制成的护肤品对金黄色葡萄球菌和粪大肠菌群有较好的抑制作用，随着复方中药提取物的比例加大，抑菌作用越明显；实施例5、6、11、12、17、18中，在取用相同百分比的复方中药提取物，但每种中药提取物均少了其中的一二味中药提取物，其对金黄色葡萄球菌和粪大肠菌群的抑制作用偏低。
2、抗炎作用测试
消炎止痒护肤品的动物实验
实验动物：小白鼠，体重18—22g。
试验药品：醋酸氟轻松乳膏；本专利的实施例1、实施例2、实施例4、实施例7、实施例8、实施例13、实施例16、实施例5、实施例10、实施例17的样品。
试验方法：对二甲苯致小白鼠耳廓急性炎症肿胀的抗炎作用。
结果如表5：
| 组别 | 剂量(g/只) | 耳廓肿胀值(mg) |
| 空白对照组 | 0.1 | 16.48 |
| 醋酸氟轻松乳膏组 | 0.1 | 10.61 |
| 实施例1组 | 0.1 | 15.11 |
| 实施例2组 | 0.1 | 11.92 |
| 实施例4组 | 0.1 | 10.95 |
| 实施例5组 | 0.1 | 13.08 |
| 实施例7组 | 0.1 | 14.97 |
| 实施例8组 | 0.1 | 11.86 |
| 实施例10组 | 0.1 | 11.45 |
| 实施例13组 | 0.1 | 14.76 |
| 实施例15组 | 0.1 | 11.66 |
| 实施例16组 | 0.1 | 11.32 |
| 实施例17组 | 0.1 | 13.73 |
实验结果表明，实施例2、4、8、10、15、16的样品具有明显的抗炎作用，实施例1、7、和实施例13(未添加中药成分)抗炎作用弱，实施例5和实施例17在取用相同百分比的复方中药提取物，但每种复方中药提取物均少了其中的一二味中药提取物，抗炎作用较弱。
3、止痒作用测试
消炎止痒护肤品的动物实验
实验动物：Hartley豚鼠，体重250—400g。
试验药品：三味清热止痒洗剂；本专利的实施例1、实施例2、实施例4、实施例6、实施例7、实施例8、实施例9、实施例11、实施例13、实施例15、实施例16、实施例17的样品。
试验方法：对Hartley豚鼠磷酸组胺止痒反应的影响。
结果如表6:
| 组别 | 剂量(ml/100g) | 致痒阈(磷酸组胺总量ug) |
| 空白对照组 | —— | 45.5±27.4 |
| 三味清热止痒洗剂组 | 0.1 | 225.5±95.1 |
| 实施例1组 | 0.1 | 80.5±65.2 |
| 实施例2组 | 0.1 | 178.5±76.4 |
| 实施例4组 | 0.1 | 214.5±75.5 |
| 实施例7组 | 0.1 | 85.5±62.7 |
| 实施例8组 | 0.1 | 161.5±86.5 |
| 实施例9组 | 0.1 | 197.5±95.5 |
| 实施例13组 | 0.1 | 92.5±82.6 |
| 实施例15组 | 0.1 | 188.5±80.5 |
| 实施例16组 | 0.1 | 199.5±85.5 |
| 实施例6组 | 0.1 | 100.5±75.2 |
| 实施例11组 | 0.1 | 112.5±93.2 |
| 实施例17组 | 0.1 | 108.5±63.2 |
实验结果表明，实施例2、4、8、9、15、16具有明显的止痒作用，实施例1、7、13(未添加中药成分)未见明显止痒作用，实施例6、实施例11、实施例17取用相同百分比的复方中药提取物，但每种中药提取物均少了其中的一二味中药提取物，止痒作用较弱。
总结：本发明的11味中药提取物必须按比例正确用在护肤品中，少了其中任一味，其消炎、止痒、抑菌均达不到要求。
Claims (4)
1.中药组合物在制备护肤品中的应用，即在制备护肤品的工艺中将复方中药提取物作为消炎抑菌作用的唯一活性成分加入护肤品中，所述复方中药提取物为断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物的质量比为2:5:2:2:3:2:3:2:2:1:1，所述中药提取物采用乙醇提取，按得到中药提取物：混合原药材=1:2—1:5的质量比例提取。
2.根据权利要求1所述的中药组合物在制备护肤品中的应用，其特征在于：所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤水工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在润肤水原料中的重量百分比为10～80%。
3.根据权利要求1所述的中药组合物在制备护肤品中的应用，其特征在于：所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤乳工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在润肤乳原料中的重量百分比为4～40%。
4.根据权利要求1所述的中药组合物在制备护肤品中的应用，其特征在于：所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在制备润肤霜工艺中作为消炎抑菌作用的唯一活性成分，所述断血流提取物、紫苏叶提取物、败酱草提取物、青蒿提取物、肿节风提取物、鸡血藤提取物、黄柏提取物、豨莶草提取物、伸筋草提取物、肉桂提取物、生姜提取物在润肤霜原料中的重量百分比为2～20%。
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