CN107412585A - A kind of disposable hand-wrist bones gel of environmental type and preparation method thereof - Google Patents

Abstract

The invention provides a green and environment-friendly hand-washing disinfection gel and a preparation method thereof, which relate to the field of hygiene products and are prepared from the following components in weight percent: 2-4% of a polymer gel matrix, 50% of a lower alcohol ‑80%, Radix Radix Radix Extract 0.1‑0.8%, Artemisia annua Extract 0.1‑0.8%, Licorice Extract 0.1‑0.8%, Artemisia Artemisiae Argyi Extract 0.5‑1%, Clove Oil 0.5‑1%, Porphyra variegata Crude Polysaccharide Extract Aloe extract 0.1‑0.8%, aloe vera extract 0.1‑1%, honeysuckle extract 0.1‑0.5%, Andrographis paniculata extract 0.1‑0.5%, seaweed 0.2‑0.8%, lecithin 0.05‑0.1%, wheat germ oil 1‑ 5%, Tween 80 0.5-1%, pH regulator 0.01-0.15%, and the rest is water. The present invention uses lower alcohol and plant extract as synergistic sterilization and anti-inflammatory ingredients and adds skin care and moisturizing ingredients to prepare the hand-free disinfection gel , stable performance, rapid sterilization, green environmental protection, non-irritating, caring for the skin of hands, and feels refreshing after use, fast drying, which can effectively prevent dry and chapped hand skin.

Description

A kind of green environment-friendly hand-washing disinfection gel and preparation method thereof

technical field

The invention relates to the field of sanitary products, in particular to a green and environment-friendly hand-washing-free disinfection gel and a preparation method thereof.

Background technique

Infectious microorganisms can enter the hospital through many different ways, and because of the complexity of hospital personnel, it is very easy to cause nosocomial infection. Warm and moist hands provide suitable conditions for the growth and reproduction of bacteria. Studies have found that the hands of medical staff, as the medium of transmission of various germs, are an important factor causing bacterial cross-infection. The incidence of nosocomial infection can be reduced to a certain extent by increasing the frequency of hand washing of patients and medical staff, but simple hand washing cannot completely remove pathogenic microorganisms. The use of suitable hand sanitizers can quickly and effectively kill a variety of pathogenic microorganisms on the skin of the hands. Hand disinfection is the easiest and most effective measure to control hospital infection.

Water-based hand sanitizer droplets are prone to splashing and dripping, while gel-type hand sanitizers can effectively prevent splashing and dripping of disinfectants. The disinfectant is made into a gel formulation, and the medical staff can use the rubbing surgical hand washing method, which is convenient and safe. The traditional disinfectant brushing method reduces the skin comfort of medical staff, and has great damage to the feeling, appearance and integrity of the hand skin, which is easy to cause the accumulation and release of resident bacteria in the deep part of the hand, and increases the chance of surgical infection. The method of rubbing and washing hands with disinfectant gel eliminates the process of scrubbing and soaking hands with disinfectant, which not only saves the time of preoperative surgical hand washing, but also does not affect the effect of hand disinfection, and the damage to the hands is small, which increases the number of surgical personnel. Handwashing compliance.

The Chinese patent application publication number CN102614113A discloses a composite no-wash disinfection gel, the main feature is that the weight percentage of raw materials is: quaternary ammonium salt disinfectant 0.05-0.5%, ethanol 50-90%, moisturizing agent 1-5% %, thickener 0.1-0.6%, deionized water 3.9-48.85%, mixed and stirred. Although the invention has the advantages of being easy to use and easy to apply, it does not add skin care ingredients and the quaternary ammonium salt disinfectant is highly irritating to the skin, which may cause side reactions such as skin allergies, and long-term use may easily cause skin roughness, chapping, and even peeling. question.

Contents of the invention

(1) Solved technical problems

Aiming at the deficiencies of the prior art, the present invention provides a green and environment-friendly hand-washing disinfection gel and a preparation method thereof, which are environmentally friendly and non-toxic, have good tissue compatibility and good film-forming properties, and can effectively resist wrinkles, prevent Wrinkles, skin care and moisturizing, the preparation process of the invention is simple, and it has a good inhibitory effect on common bacteria.

(2) Technical solution

To achieve the above object, the present invention is achieved through the following technical solutions:

A green and environment-friendly hand-washing disinfection gel is prepared from the following components in weight percent: 2-4% of polymer gel matrix, 50-80% of lower alcohol, 0.1-0.8% of Radix isatidis extract, green Artemisia extract 0.1-0.8%, licorice extract 0.1-0.8%, mugwort leaf extract 0.5-1%, clove oil 0.5-1%, Porphyra variegata crude polysaccharide extract 0.1-0.8%, aloe extract 0.1-1% , Honeysuckle extract 0.1-0.5%, Andrographis paniculata extract 0.1-0.5%, Seaweed 0.2-0.8%, Lecithin 0.05-0.1%, Wheat germ oil 1-5%, Tween 80 0.5-1%, pH adjustment Agent 0.01-0.15%, the rest is water.

Preferably, the polymer gel matrix is hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, sodium alginate, chitin derivatives, polyacrylamide One or several.

Preferably, the lower alcohol is a mixture of ethanol and isopropanol.

Preferably, the pH regulator is one or more of lactic acid, citric acid or malic acid.

Wherein, the preparation method of described disinfection gel comprises the following steps:

(1) take each raw material in proportion;

(2) Add the polymer gel matrix into cold water, control the stirring speed to 70-100r/min, control the heating rate to 1°C/min, and heat up until the polymer gel matrix is completely dissolved;

(3) After the polymer gel matrix is completely dissolved, add lower alcohol, Radix isatidis extract, Artemisia annua extract, licorice extract, Artemisia argyi leaf extract, clove oil, Porphyra zebra crude polysaccharide extract, and aloe extract in batches , honeysuckle extract, Andrographis paniculata extract, seaweed actives, lecithin, wheat germ oil and Tween 80, stir until the system becomes a uniform solution, then add pH regulator, adjust the pH value of the system to 6-7, stir for 5- After 10 hours, cool and stand for 24 hours to obtain a clear and transparent gel.

(4) After the clear and transparent gel is sterilized, it is filled and sealed to obtain the green and environment-friendly hand-washing disinfection gel.

Preferably, the disinfection method in the step (4) is ultraviolet disinfection.

In the present invention, the lower alcohol itself has excellent bactericidal ability, and its boiling point is low, so it volatilizes quickly when applied on the skin, and can play the role of rapid drying, and there is no residue after the lower alcohol volatilizes, and the price of the lower alcohol is cheap, which can reduce the need for no-cleaning. The cost of sanitizing gel.

Banlangen extract has inhibitory effects on various bacteria and viruses, especially Staphylococcus aureus, Escherichia coli, typhoid bacillus, paratyphoid bacillus, and dysentery bacillus.

Artemisia annua extract has a strong antibacterial effect on Staphylococcus epidermidis, Bacillus catarrhalis, Bacillus anthracis, and Bacillus diphtheria, and also has a certain inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, Shigella, and Mycobacterium tuberculosis.

Licorice flavonoids in licorice root have anti-inflammatory activity, and pre-clinical test results show that flavonoids can kill most Helicobacter pylori that cause gastric ulcer and enteritis.

Artemisia argyi leaf extract has inhibitory effects on Bacillus anthracis, A-hemolytic streptococcus, B-hemolytic streptococcus, diphtheria bacillus, pneumococcus, Staphylococcus aureus, Bacillus subtilis, etc., and it also has inhibitory effects on common pathogenic skin fungi inhibition.

Clinical studies in hospitals have found that clove oil has a strong bactericidal effect, can kill Helicobacter pylori, and has inhibitory effects on Staphylococcus, Streptococcus, Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa.

Porphyra variegata crude polysaccharide extract and aloe vera extract not only have bactericidal and anti-inflammatory effects, but also can improve skin texture, moisturize and lock water. Seaweed active ingredient is an active ingredient with antibacterial effect extracted from various algae in the ocean. Non-toxic, non-irritating, and high antibacterial efficiency, it can effectively inhibit the reproduction of Escherichia coli, Staphylococcus aureus and Candida albicans, and reduce the damage of bacteria to the human body. It has strong adhesion and can remain on the skin surface for a long time , play a long-term antibacterial effect.

Wheat germ oil is a kind of grain germ oil made from wheat germ, which can promote the metabolism of the skin, has the functions of anti-wrinkle, anti-wrinkle, anti-aging, eliminating scars and promoting skin moisturizing, making the skin moisturized.

Honeysuckle extract and Andrographis paniculata extract have significant antibacterial activity, and are natural Chinese herbal medicine extracts, mild in nature, non-irritating to the human body, and have a high rate of bacterial killing in synergy with lower alcohols.

(3) Beneficial effects

The invention provides a green and environment-friendly hand-washing disinfection gel, which uses lower alcohols and plant extracts as synergistic sterilization and anti-inflammatory ingredients and adds skin care and moisturizing ingredients to prepare the hand-washing disinfection gel, which has stable performance, rapid sterilization, and is green and environmentally friendly. It is non-irritating and has the effect of caring for the skin of hands. After use, it feels refreshing and dries quickly, which can effectively prevent dry and chapped skin of hands.

detailed description

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are part of the present invention Examples, not all examples. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

Example 1:

A green and environment-friendly hand sanitizing gel, which is prepared from the following components in weight percent: 3% hydroxypropyl methylcellulose, 70% lower alcohol, 0.5% Radix isatidis extract, 0.5% Artemisia annua extract %, 0.5% licorice extract, 0.5% mugwort leaf extract, 1% clove oil, 0.5% crude polysaccharide extract of Porphyra variegata, 0.5% aloe extract, 0.2% honeysuckle extract, 0.3% Andrographis paniculata extract, seaweed active 0.6%, lecithin 0.07%, wheat germ oil 4%, Tween 800.7%, pH regulator 0.1%, and the rest is water.

Wherein, the lower alcohol is formed by mixing ethanol and isopropanol in a weight ratio of 1:1.

Wherein, the pH regulator is formed by mixing lactic acid and citric acid in a weight ratio of 1:2.

The preparation method of above-mentioned disinfection gel, comprises the following steps:

(1) take each raw material in proportion;

(2) Add hydroxypropyl methylcellulose into cold water, control the stirring speed to 80r/min, control the heating rate to 1°C/min, and heat up until the polymer gel matrix is completely dissolved;

(3) After the hydroxypropyl methylcellulose is completely dissolved, add lower alcohol, isatis root extract, artemisia annua extract, licorice extract, mugwort leaf extract, clove oil, Porphyra zebra crude polysaccharide extract, aloe vera in batches Extract, honeysuckle extract, Andrographis paniculata extract, seaweed, lecithin, wheat germ oil and Tween 80, stir until the system becomes a uniform solution, then add a pH regulator, adjust the pH of the system to 6-7, stir After 5 hours, cool and stand for 24 hours to obtain a clear and transparent gel.

(4) After ultraviolet sterilizing the obtained clear and transparent gel, filling and sealing, the green and environment-friendly hand-washing disinfection gel can be obtained.

Example 2:

A green and environment-friendly hand-washing disinfection gel, which is prepared from the following components in weight percentage: 4% polymer gel matrix, 80% lower alcohol, 0.1% Radix isatidis extract, 0.4% Artemisia annua extract, 0.8% licorice extract, 1% mugwort leaf extract, 0.5% clove oil, 0.2% crude polysaccharide extract of Porphyra variegata, 1% aloe extract, 0.4% honeysuckle extract, 0.5% andrographis paniculata extract, 0.2% seaweed extract , lecithin 0.05%, wheat germ oil 1%, Tween 800.9%, pH regulator 0.07%, and the rest is water.

Wherein, the polymer gel matrix is formed by mixing hydroxyethyl cellulose, hydroxypropyl cellulose and methyl cellulose in a weight ratio of 1:2:1.

Wherein, the lower alcohol is formed by mixing ethanol and isopropanol in a weight ratio of 2:1.

The preparation method of above-mentioned disinfection gel, comprises the following steps:

(1) take each raw material in proportion;

(2) Add the polymer gel matrix into cold water, control the stirring speed to 70r/min, control the heating rate to 1°C/min, and heat up until the polymer gel matrix is completely dissolved;

(3) After the polymer gel matrix is completely dissolved, add lower alcohol, Radix isatidis extract, Artemisia annua extract, licorice extract, Artemisia argyi leaf extract, clove oil, Porphyra zebra crude polysaccharide extract, and aloe extract in batches , honeysuckle extract, andrographis paniculata extract, seaweed, lecithin, wheat germ oil and Tween 80, stir until the system becomes a uniform solution, then add lactic acid, adjust the pH of the system to 6-7, stir for 10 hours, then cool down After standing for 24 hours, a clear and transparent gel can be obtained.

(4) After ultraviolet sterilizing the obtained clear and transparent gel, filling and sealing, the green and environment-friendly hand-washing disinfection gel can be obtained.

Example 3:

A green and environment-friendly hand-washing disinfection gel, which is prepared from the following components in weight percentage: 2% polymer gel matrix, 60% lower alcohol, 0.8% Radix isatidis extract, 0.1% Artemisia annua extract, 0.1% licorice extract, 0.8% mugwort leaf extract, 0.8% clove oil, 0.8% crude polysaccharide extract of Porphyra variegata, 0.8% aloe extract, 0.5% honeysuckle extract, 0.1% Andrographis paniculata extract, 0.5% seaweed extract , lecithin 0.08%, wheat germ oil 5%, Tween 801%, pH regulator 0.15%, and the rest is water.

Wherein, the polymer gel matrix is formed by mixing hydroxyethyl cellulose, sodium alginate and polyacrylamide in a weight ratio of 1:1:1.

Wherein, the lower alcohol is formed by mixing ethanol and isopropanol in a weight ratio of 3:1.

The preparation method of above-mentioned disinfection gel, comprises the following steps:

(1) take each raw material in proportion;

(2) Add the polymer gel matrix into cold water, control the stirring speed to 100r/min, control the heating rate to 1°C/min, and heat up until the polymer gel matrix is completely dissolved;

(3) After the polymer gel matrix is completely dissolved, add lower alcohol, Radix isatidis extract, Artemisia annua extract, licorice extract, Artemisia argyi leaf extract, clove oil, Porphyra zebra crude polysaccharide extract, and aloe extract in batches , honeysuckle extract, andrographis paniculata extract, seaweed, lecithin, wheat germ oil and Tween 80, stir until the system becomes a uniform solution, then add malic acid, adjust the pH value of the system to 6-7, stir for 8 hours, After cooling and standing for 24 hours, a clear and transparent gel can be obtained.

(4) After ultraviolet sterilizing the obtained clear and transparent gel, filling and sealing, the green and environment-friendly hand-washing disinfection gel can be obtained.

Example 4:

A green and environment-friendly hand-washing disinfection gel, which is prepared from the following components in weight percentage: 3% polymer gel matrix, 50% lower alcohol, 0.2% Radix isatidis extract, 0.4% Artemisia annua extract, 0.3% licorice extract, 1% mugwort leaf extract, 0.5% clove oil, 0.1% polysaccharide extract from Porphyra variegata, 0.1% aloe extract, 0.1% honeysuckle extract, 0.5% Andrographis paniculata extract, 0.6% seaweed extract , lecithin 0.1%, wheat germ oil 1%, Tween 80 0.5%, pH regulator 0.01%, and the rest is water.

The preparation method of the above-mentioned disinfection gel is basically the same as in Example 1, the difference is that the polymer gel matrix is a chitin derivative, the lower alcohol is mixed with ethanol and isopropanol in a weight ratio of 4:1, and the pH regulator For citric acid, the stirring speed in the step (2) is 70r/min, and the stirring time after adjusting the pH value in the step (3) is 6h.

Example 5:

A green and environment-friendly hand-washing disinfection gel is prepared from the following components in weight percentage: 4% polymer gel matrix, 80% lower alcohol, 0.1% Radix isatidis extract, 0.7% Artemisia annua extract, 0.5% licorice extract, 0.5% mugwort leaf extract, 0.6% clove oil, 0.5% crude polysaccharide extract of Porphyra variegata, 0.6% aloe extract, 0.2% honeysuckle extract, 0.5% Andrographis paniculata extract, 0.8% seaweed extract , lecithin 0.06%, wheat germ oil 4%, Tween 800.6%, pH regulator 0.12%, and the rest is water.

The preparation method of the above-mentioned disinfectant gel is basically the same as in Example 1, the difference is that the polymer gel matrix is mixed with hydroxyethyl cellulose and methyl cellulose at a weight ratio of 1:2, and the lower alcohol is ethanol and iso Propanol is mixed by weight ratio 5:1, and pH adjuster is that lactic acid, citric acid and malic acid are mixed by weight ratio 1:1:1, and the stirring velocity in step (2) is 90r/min, step ( 3) The stirring time after adjusting the pH value is 9h.

The present invention's hands-free disinfection gel bacteria quantitative killing test results:

The results of the quantitative killing experiment of the hands-free disinfection gel bacteria prepared by Examples 1-5 are shown in Table 1, and the bactericidal effect in the table is the bactericidal rate after 25s of sterilization:

Table 1: Experimental results

To sum up, the embodiment of the present invention has the beneficial effects of good bactericidal effect, many types of bacteria and short sterilizing time.

It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is a relationship between these entities or operations. any such actual relationship or order exists between them. Furthermore, the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article, or apparatus comprising a set of elements includes not only those elements, but also includes elements not expressly listed. other elements of or also include elements inherent in such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article or apparatus comprising said element.

The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be described in the foregoing embodiments Modifications are made to the recorded technical solutions, or equivalent replacements are made to some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (6)

1. a kind of disposable hand-wrist bones gel of environmental type, it is characterised in that by the component preparation of following weight percentage Into：Macromolecule gel matrix 2-4%, lower alcohol 50-80%, isatis root extract 0.1-0.8%, Artemisinin 0.1- 0.8%th, licorice 0.1-0.8%, Folium Artemisiae Argyi extract 0.5-1%, caryophyllus oil 0.5-1%, Crude Polysaccharide from Porphyra yezoensis extraction Thing 0.1-0.8%, extract solution from aloe 0.1-1%, Honegsukle flower P.E 0.1-0.5%, Andrographis Paniculata 0.1-0.5%, sea Algae cytokines 0.2-0.8%, lecithin 0.05-0.1%, wheat-germ oil 1-5%, Tween 80 0.5-1%, pH adjusting agent 0.01- 0.15%th, remaining is water.

2. the disposable hand-wrist bones gel of environmental type as claimed in claim 1, it is characterised in that the Macromolecule gel matrix Derive for hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methylcellulose, sodium alginate, chitin One or several kinds in thing, polyacrylamide.

3. the disposable hand-wrist bones gel of environmental type as claimed in claim 1, it is characterised in that the lower alcohol be ethanol and Isopropanol mixes.

4. the disposable hand-wrist bones gel of environmental type as claimed in claim 1, it is characterised in that the pH adjusting agent is breast One or several kinds in acid, citric acid or malic acid.

5. the preparation method of the disposable hand-wrist bones gel of environmental type as claimed in claim 1, it is characterised in that including following Step：

(1) each raw material is weighed in proportion；

(2) Macromolecule gel matrix is added in cold water, it is 70-100r/min to control mixing speed, and it is 1 to control programming rate DEG C/min, heat temperature raising is until Macromolecule gel matrix is completely dissolved；

(3) after Macromolecule gel matrix is completely dissolved, lower alcohol, isatis root extract, Artemisinin, radix glycyrrhizae is added portionwise Extract, Folium Artemisiae Argyi extract, caryophyllus oil, Crude Polysaccharide from Porphyra yezoensis extract, extract solution from aloe, Honegsukle flower P.E, Herba Andrographitis Extract, marine alga cytokines, lecithin, wheat-germ oil and Tween 80, after stirring to system into uniform solution, add pH regulations Agent, regulation system pH value to 6-7, after stirring 5-10h, the gel of clear is can obtain after cooling standing 24h.

(4) after the gel sterilization of clear being obtained, filling and sealing, you can obtain the disposable hand-wrist bones of the environmental type and coagulate Glue.

6. the disposable hand-wrist bones gel of environmental type as claimed in claim 5, it is characterised in that disappearing in the step (4) Malicious mode is disinfection by ultraviolet light.