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CN106715395B - 作为taar调节剂的6-氨基-5，6，7，8-四氢萘-2-基或3-氨基色满-7-基衍生物 - Google Patents

作为taar调节剂的6-氨基-5，6，7，8-四氢萘-2-基或3-氨基色满-7-基衍生物 Download PDF

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CN106715395B
CN106715395B CN201580035425.9A CN201580035425A CN106715395B CN 106715395 B CN106715395 B CN 106715395B CN 201580035425 A CN201580035425 A CN 201580035425A CN 106715395 B CN106715395 B CN 106715395B
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amino
tetrahydronaphthalen
carboxamide
tetrahydronaphthalene
trifluoromethyl
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CN106715395A (zh
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朱塞佩·切切里
吉多·加利
安尼科·格尔格勒
罗杰·诺克罗斯
菲利普·普夫利格
艾琳娜·特尔勒
菲利普·施密德
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F Hoffmann La Roche AG
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* Cited by examiner, † Cited by third party
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CN101068801A (zh) * 2004-10-14 2007-11-07 艾博特股份有限两合公司 适用于治疗对于多巴胺d3受体的调节有反应的疾病的芳基磺酰基甲基或芳基磺酰胺取代的芳族化合物
WO2014041007A1 (en) * 2012-09-14 2014-03-20 F. Hoffmann-La Roche Ag Pyrazole carboxamide derivatives as taar modulators for use in the treatment of several disorders, such as depression, diabetes and parkinson's disease

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CA2545100A1 (en) * 2003-11-08 2005-05-19 Bayer Healthcare Ag Bicyclic amide, carbamate or urea derivatives as vanilloid receptor modulators

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* Cited by examiner, † Cited by third party
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CN101068801A (zh) * 2004-10-14 2007-11-07 艾博特股份有限两合公司 适用于治疗对于多巴胺d3受体的调节有反应的疾病的芳基磺酰基甲基或芳基磺酰胺取代的芳族化合物
WO2014041007A1 (en) * 2012-09-14 2014-03-20 F. Hoffmann-La Roche Ag Pyrazole carboxamide derivatives as taar modulators for use in the treatment of several disorders, such as depression, diabetes and parkinson's disease

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