CN106310362A - Traditional Chinese medicine liquid dressing and preparation method - Google Patents

Abstract

The invention belongs to the field of medical dressings, and in particular relates to a traditional Chinese medicine liquid dressing and a preparation method, which contains the following components in weight percentage: 1.0%-6.0% of film-forming material, 2.0%-4.0% of glycerin, and 0.5%-3.0% of menthol , coptis extract 0.3%‑1.0%, honeysuckle extract 1.0%‑2.0%, and the rest is solvent. The traditional Chinese medicine liquid dressing of the present invention can be obtained by mixing the above components in sequence, stirring evenly and filling. The traditional Chinese medicine liquid dressing of the invention has simple ingredients, short film-forming time, waterproof effect, good antibacterial effect, no drug resistance, can promote wound healing, and shorten wound healing time.

Description

A kind of traditional Chinese medicine liquid dressing and its preparation method

technical field

The invention belongs to the field of medical dressings, in particular to a traditional Chinese medicine liquid dressing and a preparation method.

Background technique

Medical dressings play a role in protecting the wound, reducing infection, absorbing secretions and promoting wound healing during the wound healing process. Traditional gauze dressings have the advantages of good absorption, wide range of sources, and simple preparation, but they also have problems such as inability to keep the wound moist, poor biocompatibility, easy tissue adhesion, easy penetration of pathogens, and wound infection. Antibiotics combined with gauze dressings are clinically used to prevent wound infection, but long-term use of antibiotics will lead to drug resistance.

With the development of medical treatment technology, people's requirements for medical dressings have increased, and new liquid dressings have emerged as the times require. Liquid dressings are stored in liquid form before use, and are not limited by the location and size of the wound, and can quickly form a polymer film at the wound site. The liquid dressing has good air permeability and water resistance, and there is no need to tear it off after use, avoiding secondary injuries caused by changing the dressing. Liquid dressings are composed of polymer film-forming materials, solvents and functional substances. Polymer film-forming materials include natural polymer materials and synthetic polymer materials. Natural polymer materials include chitin, chitosan and its derivatives, sodium alginate, etc. These polymer materials have high safety and good biocompatibility. Synthetic polymer materials include polyvinyl alcohol, polyvinyl butyral, carbomer, etc. This type of polymer material has a special chemical structure and can be degraded under the action of acid or alkali. At the same time, it can provide a slightly moist, slightly acidic and low-oxygen environment for the wound surface, which is conducive to wound healing. Functional substances include cosolvents, adhesion promoters, antibacterial and anti-inflammatory components, etc. Antibacterial and anti-inflammatory ingredients include nano-silver, povidone-iodine, and dichlorophenoxychlorophene, but long-term use of chemical antibacterial agents will cause harm to health.

Traditional Chinese medicine is unique in the treatment of skin wounds due to its advantages of antibacterial and anti-inflammatory, safe and non-toxic, and not easy to produce drug resistance. However, traditional Chinese medicine requires a large dose to exert its curative effect. Applying traditional Chinese medicine powder to the wound and then bandaging it with gauze has problems such as inconvenient storage and use, and the powder is easy to fall off, which limits its clinical application.

The present invention combines traditional Chinese medicine with liquid film-forming matrix to prepare a traditional Chinese medicine liquid dressing, so that the liquid dressing has antibacterial and anti-inflammatory properties, and at the same time, it can provide a slightly humid environment for the wound surface, has excellent air permeability and waterproof performance, does not produce drug resistance, and can Effectively promote wound healing.

Contents of the invention

The purpose of the present invention is to combine the advantages of liquid dressings and traditional Chinese medicines to provide a Chinese medicinal liquid dressing containing extracts of Coptis chinensis and honeysuckle and a preparation method. The liquid dressing of the present invention can quickly form a film on the wound and has good biocompatibility , antibacterial, moisture permeability, and at the same time it is safe and non-toxic, not easy to produce drug resistance, and conducive to wound healing.

The object of the present invention is achieved through the following technical scheme: a kind of Chinese medicine liquid dressing, is characterized in that, comprises the raw material of following percentage by weight:

The film-forming material is polyvinyl alcohol or polyvinyl butyral.

The solvent is distilled water or ethanol.

A preferred liquid dressing comprises the following raw materials in percentage by weight:

A preferred liquid dressing comprises the following raw materials in percentage by weight:

The degree of alcoholysis of the polyvinyl alcohol is 87.0-89.0 mol%, and the viscosity is 20.5-24.5mpa.s.

The polyvinyl butyral has a viscosity of 15.0-35.0mpa.s and a butyraldehyde group content of 45.0%-49.0%.

Described a kind of Chinese medicine liquid dressing is characterized in that, the preparation of described Chinese medicine extract can comprise the following steps:

1) Grind Coptidis rhizome, add its powder into ethanol solution with a volume fraction of 60% to infiltrate overnight, heat and reflux for extraction 3 times, filter while hot, combine the filtrates for 3 times, concentrate the filtrate and freeze-dry to obtain Coptis chinensis extract ;

2) The honeysuckle was pulverized, and its powder was added to an ethanol solution with a volume fraction of 60% to infiltrate overnight, then heated and refluxed for extraction twice, filtered while hot, combined with filtrates, concentrated and freeze-dried to obtain a honeysuckle extract.

The preparation method of said a kind of traditional Chinese medicine liquid dressing, is characterized in that, comprises the following steps:

1) heating and dissolving the film-forming material, stirring to cool down;

2) take menthol, join in absolute ethanol solution and dissolve;

3) Weighing the Coptidis Rhizoma extract, adding it to an ethanol solution with a volume fraction of 60%-70% for dissolving;

4) Weighing the honeysuckle extract, adding it to an ethanol solution with a volume fraction of 60%-70% for dissolving;

5) Add glycerin, menthol solution, Coptidis Rhizoma extract solution, and Flos Lonicerae extract solution in proportion to the film-forming material solution in process 1) in sequence, and stir until they are evenly mixed;

6) Fill it and get it.

Adopting the above scheme, the invention provides a kind of traditional Chinese medicine liquid dressing. Among them, coptis and honeysuckle as antibacterial substances. Coptidis extract has broad-spectrum antibacterial effect, and has significant inhibitory effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Shigella dysenteriae, etc. Coptidis extract also has immunomodulatory and antitumor effects. Honeysuckle has a long history of medicinal use, and it is known as "antibiotics in traditional Chinese medicine". Honeysuckle extract has certain inhibitory effect on acute, granulomatous and chronic inflammation, has strong broad-spectrum antibacterial effect, and also has antioxidant and anti-tumor activities. Coptis chinensis and honeysuckle are used in combination, which has antibacterial and anti-inflammatory effects, and can broaden the antibacterial spectrum, making it less likely to produce drug resistance.

The film-forming materials used in the present invention are high-molecular medical materials with good biocompatibility. Among them, polyvinyl alcohol (PVA) is a water-soluble polymer material with good film-forming properties, softness and hygroscopicity, and is the most widely used film-forming material. Polyvinyl butyral (PVB) can be dissolved in various organic solvents such as alcohols, esters, and ketones. It takes less time to form a film and has excellent film-forming properties and stability.

In the invention, the extract of traditional Chinese medicine is added to the film-forming material to prepare a liquid dressing; glycerin is used as a humectant to enhance the moisturizing effect of the antibacterial film, making the antibacterial film soft and close to the affected part. Menthol acts as a transdermal accelerator, and at the same time it acts on the skin, has a cooling and antipruritic effect, and produces a sense of comfort.

The traditional Chinese medicine liquid dressing of the present invention forms a film after smearing or spraying, has good biocompatibility, can effectively resist bacterial infection, keep the wound surface moist, and will not cause secondary damage to the wound due to changing the dressing, thereby promoting wound healing. Small area skin cuts, bruises, abrasions and burns etc.

In summary, the liquid dressing of traditional Chinese medicine of the present invention has the following advantages: 1) good antibacterial and anti-inflammatory effect, shortens wound healing time, 2) facilitates observation of wound healing, 3) is difficult to produce drug resistance, 4) good water resistance, 5) ) can quickly form a film, 6) is safe and non-toxic, has good biocompatibility, and 7) has a simple process and is suitable for large-scale production.

Description of drawings:

Fig. 1 (A) is the transmission electron micrograph of the Chinese medicine liquid dressing in Example 1 of the present invention; (B) is the transmission electron microscope picture of the Chinese medicine liquid dressing in Example 4 of the present invention.

Fig. 2 (A) is the bacteriostatic zone test result figure of the Chinese medicine liquid dressing in the embodiment of the present invention 1 to Staphylococcus aureus; (B) is the effect of the Chinese medicine liquid dressing in the embodiment of the present invention 1 to Escherichia coli The results of the zone of inhibition test.

Fig. 3 is rat scald wound healing appearance figure (the 3rd, 7, 15, 21 days), wherein, A is the Chinese medicine liquid dressing group in embodiment 4; B is positive control group (erythromycin group); C is Negative control group (normal saline group).

Fig. 4 is the scalded rat pathological detection result figure, and wherein, A is the scalded rat; B is the Chinese medicine liquid dressing group in the embodiment of the present invention 4; C is the positive control group (erythromycin group); D is the negative control group (normal saline group).

detailed description:

The present invention is further described below in conjunction with embodiment.

Preparation of Coptidis Rhizoma Extract: Grind Coptidis Rhizoma, add its powder to 12 times the volume fraction of 60% ethanol solution for soaking overnight, then heat to reflux for 1 hour, filter while it is hot, add 10 times the volume fraction of 60% ethanol solution to the filter residue Heat the ethanol solution under reflux for 1 hour, filter while it is hot, add 8 times the amount of ethanol solution with a volume fraction of 60% to the filter residue, heat and reflux it for extraction for 1 hour, filter it again while it is hot, combine the filtrates for 3 times, concentrate the filtrates and then freeze-dry to obtain the extract of Coptidis Rhizome. Wherein the berberine hydrochloride content is 27.5%, the palmatine content is 7.3%, the coptisine content is 6.2%, and the epiberberine content is 4.2%;

Preparation of honeysuckle extract: Grind honeysuckle, take its powder and add 10 times the volume fraction of 60% ethanol solution to soak overnight, then heat and reflux for 2 hours, filter while it is hot, add 8 times the volume fraction of 60% ethanol solution to the filter residue The ethanol was heated to reflux for 2 hours, filtered again while it was hot, and the filtrates were combined, concentrated and then freeze-dried to obtain a honeysuckle extract, wherein the content of chlorogenic acid was 6.5%.

Example 1

A kind of traditional Chinese medicine liquid dressing, comprises the raw material of following percentage by weight, takes 100g as example:

The preparation method is as follows:

1) Weigh 2.0g of polyvinyl alcohol, add it into 30mL of distilled water, and mechanically stir at 60°C until completely dissolved to form solution A;

2) Weigh 0.7g of menthol, add it into 6mL of absolute ethanol solution, stir until completely dissolved, and form solution B;

3) Weigh 0.3g of Coptis chinensis extract, add it into 23mL ethanol solution with a volume fraction of 60%, stir until completely dissolved, and form solution C;

4) Weigh 1.0 g of honeysuckle extract, add it to 45 mL of ethanol solution with a volume fraction of 60%, and stir until completely dissolved to form solution D;

5) Add 1.6mL glycerin, solutions B, C, and D to solution A in turn, and stir well;

6) Filling.

Example 2

A kind of traditional Chinese medicine liquid dressing, comprises the raw material of following percentage by weight, takes 100g as example:

The preparation method is as follows:

1) Weigh 4.0g of polyvinyl alcohol, add it into 27mL of distilled water, and mechanically stir at 60°C until completely dissolved to form solution A;

2) Weigh 1.1g of menthol, add it into 6mL of absolute ethanol solution, stir until completely dissolved, and form solution B;

3) Weigh 0.5 g of Coptidis rhizome extract, add it into 23 mL of ethanol solution with a volume fraction of 60%, stir until completely dissolved, and form solution C;

4) Weigh 1.0 g of honeysuckle extract, add it to 45 mL of ethanol solution with a volume fraction of 60%, and stir until completely dissolved to form solution D;

5) Add 1.8mL glycerin, solutions B, C, and D to solution A in turn, and stir well;

6) Filling.

Example 3

A kind of traditional Chinese medicine liquid dressing, comprises the raw material of following percentage by weight, takes 100g as example:

The preparation method is as follows:

1) Weigh 5.0g of polyvinyl alcohol, add it into 26mL of distilled water, and mechanically stir at 60°C until completely dissolved to form solution A;

2) Weigh 1.5g of menthol, add it into 4mL of absolute ethanol solution, stir until completely dissolved, and form solution B;

3) Weigh 0.8g of Coptis chinensis extract, add it into 23mL ethanol solution with a volume fraction of 60%, stir until completely dissolved, and form solution C;

4) Weigh 1.6g of honeysuckle extract, add it to 45mL ethanol solution with a volume fraction of 60%, and stir until completely dissolved to form solution D;

5) Add 2.0mL glycerin, solutions B, C, and D to solution A in turn, and stir well;

6) Filling.

Example 4

A kind of traditional Chinese medicine liquid dressing, comprises the raw material of following percentage by weight, takes 100g as example:

The preparation method is as follows:

1) Weigh 2.2g of polyvinyl butyral, add it to 45mL of absolute ethanol solution, and mechanically stir at 50°C until completely dissolved to form solution A;

2) Weigh 1.4g of menthol, add it into 5mL of absolute ethanol solution, stir until completely dissolved, and form solution B;

3) Weigh 0.3g of Coptis chinensis extract, add it into 27mL ethanol solution with a volume fraction of 70%, and stir until completely dissolved to form solution C;

4) Weigh 1.0 g of honeysuckle extract, add it to 36 mL of ethanol solution with a volume fraction of 70%, and stir until completely dissolved to form solution D;

5) Add 1.6mL glycerin, solutions B, C, and D to solution A in turn, and stir well;

6) Filling.

Example 5

A kind of traditional Chinese medicine liquid dressing, comprises the raw material of following percentage by weight, takes 100g as example:

The preparation method is as follows:

1) Weigh 3.8g of polyvinyl butyral, add it to 37mL of absolute ethanol solution, and mechanically stir at 50°C until completely dissolved to form solution A;

2) Weigh 2.7g of menthol, add it into 6mL of absolute ethanol solution, stir until completely dissolved, and form solution B;

3) Weigh 0.6g of Coptis chinensis extract, add it into 27mL ethanol solution with a volume fraction of 70%, stir until completely dissolved, and form solution C;

4) Weigh 1.0 g of honeysuckle extract, add it to 38 mL of ethanol solution with a volume fraction of 70%, and stir until completely dissolved to form solution D;

5) Add 2.0mL glycerin, solutions B, C, and D to solution A in turn, and stir well;

6) Filling.

Example 6

A kind of traditional Chinese medicine liquid dressing, comprises the raw material of following percentage by weight, takes 100g as example:

The preparation method is as follows:

1) Weigh 6.0g of polyvinyl butyral, add it to 33mL of absolute ethanol solution, and mechanically stir at 50°C until completely dissolved to form solution A;

2) Weigh 3.0g of menthol, add it into 3mL of absolute ethanol solution, stir until completely dissolved, and form solution B;

3) Weigh 1.0 g of Coptis chinensis extract, add it to 34 mL of ethanol solution with a volume fraction of 70%, stir until completely dissolved, and form solution C;

4) Weigh 1.5g of honeysuckle extract, add it to 32mL ethanol solution with a volume fraction of 70%, and stir until completely dissolved to form solution D;

5) Add 3.0mL glycerin, solutions B, C, and D to solution A in turn, and stir well;

6) Filling.

The transmission electron microscope test of embodiment 7 Chinese medicine liquid dressing of the present invention

Take the traditional Chinese medicine liquid dressing prepared in Examples 1 and 4, use a pipette gun to take a small amount and drop it on a carbon-coated copper grid with a diameter of 3 mm, absorb excess water with filter paper, and dry it under an infrared lamp for 1 hour. The copper mesh was sent to a transmission electron microscope, and imaged and observed under 200kv voltage bombardment, so as to characterize the internal structure of the dressing. The results are shown in Figure 1.

The water vapor transmission rate of embodiment 8 Chinese medicine liquid dressing of the present invention

Measure 15mL of the traditional Chinese medicine liquid dressing prepared in Examples 1-6, respectively spread it on a 7cm×11.5cm transparent glass plate, place it in a 50°C oven to dry for 30min, take it out, and peel off the drug film from the glass plate; Take by weighing 0.5g of the drug film, and cover it on the mouth of an open vial (with an area of 1.77cm ² ), wherein the vial contains 10g of anhydrous CaCl ₂ , and seal around the mouth of the bottle with a polytetrafluoroethylene tape; the positive control group Adopt sealed vial, contain 10g anhydrous CaCl in the vial _; Negative control group adopts the vial of opening, contain 10g anhydrous CaCl in the vial _; All vials are placed in desiccator, wherein contain saturated NaCl solution (its The relative humidity is 70% RH), the desiccator is placed in a 37°C oven, the quality of the vial is measured at a certain time interval, and the water vapor transmission rate is calculated. The results are shown in Table 1.

Table 1 Experimental results of water vapor transmission rate of traditional Chinese medicine liquid dressing

As can be seen from Table 1, compared with the negative control group, the experimental group can effectively reduce the water vapor transmission rate, so the drug film formed by the traditional Chinese medicine liquid dressing of the present invention can prevent water loss and keep the wound moist.

The film-forming time of embodiment 9 Chinese medicine liquid dressings of the present invention

Measure 1.5mL of the traditional Chinese medicine liquid dressing prepared in Examples 1 and 4, spread it on a 2.5cm×7.5cm transparent glass plate, and start timing with a stopwatch. When the membrane body is lifted from the glass plate, the timing stops. The results are shown in Table 2.

Table 2 Test results of film-forming time of Chinese herbal liquid dressing

As can be seen from Table 2, the film-forming time of the traditional Chinese medicine liquid dressing of the present invention shortens as the temperature increases, and the film-forming time at 37° C. can be shortened to 2 minutes.

The antibacterial effect of embodiment 10 Chinese medicine liquid dressing of the present invention

Determination of antibacterial activity of traditional Chinese medicine extracts in vitro: the minimum inhibitory concentration (MIC) of traditional Chinese medicine extracts was determined by agar dilution method. The experimental strains were Staphylococcus aureus ATCC29213, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC25922, Klebsiella pneumonia ATCC700603 and Pseudomonas aeruginosa (Pseudomonasaeruginosa CMCC (B) 10104) and so on. The results showed that the MIC value of Coptidis Rhizoma extract was 2.5mg/mL, and the MIC value of Honeysuckle extract was 10mg/mL.

Determination of antibacterial effect of traditional Chinese medicine liquid dressing:

Sample preparation: Weigh 50 mg of Coptis chinensis extract, add it to 10 mL of ethanol solution with a volume fraction of 60%, to obtain a solution of Coptis chinensis extract; weigh 100 mg of honeysuckle extract, add it to 10 mL of ethanol solution with a volume fraction of 60%, Obtain honeysuckle extract liquid. Get the Chinese medicinal liquid dressing prepared in Examples 1-6.

Bacteria selection: Staphylococcus aureus (Staphylococcus aureus ATCC29213) represents Gram-positive bacteria, Escherichia coli (Escherichia coli ATCC25922) represents Gram-negative bacteria, purchased from Kanghua Medical Technology Industrial Center, Jiangsu Province.

Culture medium: the bacterial culture medium is a nutrient agar medium with a pH value of 7.2±0.2. The medium was purchased from Beijing Sanyao Science and Technology Development Company.

Measuring method: measure the antibacterial zone size of the traditional Chinese medicine liquid dressing prepared in Examples 1-6 with the plate punching method, and evaluate the antibacterial activity of the traditional Chinese medicine liquid dressing of the present invention. Add 2 mL of the diluted bacterial suspension (10 ⁸ cfu/mL) into a liquid medium with a volume of 200 mL in a water bath at 50°C, and mix well. Transfer 20 mL of the above culture medium mixed with the bacterial suspension to a petri dish to solidify (the number of colonies is 10 ⁶ -10 ⁷ cfu/mL). Punch 3 holes on the plate with a puncher, evenly distributed, 1.5cm away from the side, pick out the agar block with a sterilized toothpick, and seal the bottom with flame. 70 μL of liquid dressing was injected into each well, and incubated at 37° C. for 24 hours. The results of the inhibition zone test are shown in Figure 2. The diameter of the inhibition zone is shown in Table 3.

Table 3 The diameter of the antibacterial zone of traditional Chinese medicine liquid dressing

As can be seen from Table 3, Coptis chinensis extract has better inhibitory effect on Staphylococcus aureus and Escherichia coli, and the inhibitory effect of honeysuckle extract on Staphylococcus aureus is better than that on Escherichia coli; Compared with the traditional Chinese medicine extract, the traditional Chinese medicine liquid dressing of the present invention has enhanced antibacterial effect, and with the increase of the content of the traditional Chinese medicinal extract, the antibacterial effect is also enhanced.

The safety evaluation of embodiment 11 Chinese medicine liquid dressing of the present invention

Take a male SD rat with a body weight of 200-220g (purchased from Zhejiang Experimental Animal Center), use 8% sodium sulfide solution as a depilatory, depilate the back of the rat, and wash off the hair and depilatory with warm water. The traditional Chinese medicine liquid dressing prepared in Examples 1-6 was applied to the depilatory site, 500 μL per rat, once a day, continuously applied for one week and observed, and its safety was evaluated. The results show that, compared with the rat skin without smearing, the traditional Chinese medicine liquid dressing of the present invention does not have any adverse reaction to the skin.

Embodiment 12 Chinese medicine liquid dressing of the present invention is to the healing effect of scalded wound of rat

Scald rat model: The experiment uses male SD rats with a body weight of 200-220g (purchased from Zhejiang Experimental Animal Center). After one week of adaptive feeding, they are randomly divided into positive control group (erythromycin group), negative The control group (physiological saline group) and the experimental group (traditional Chinese medicine liquid dressing prepared in Examples 1-6), 6 rats in each group. The rat was anesthetized, and the back of the rat was depilated with 8% sodium sulfide solution, and the depilated hair and depilatory were washed with warm water. After 24 hours, the rats were anesthetized with ether, and the parts to be scalded were disinfected with 75% alcohol solution. Use a 50g weight (2cm in diameter) for scalding, place the weight in boiling water at 100°C for 1 min, dry the water quickly, place it on the depilated area for 15 seconds, remove the weight immediately, and place the weights prepared in Examples 1-6 respectively 500 μL of traditional Chinese medicine liquid dressing, 500 μL of normal saline, and 0.5 g of erythromycin were applied to the wound, and each rat was reared in a single cage. The dressings were changed once a day on the wounds of the rats, and the wound area was measured on the 3rd, 5th, 7th, 11th, 15th, and 21st days after injury to record the change of the wound area and calculate the wound healing rate. Calculation of wound healing rate: draw the wound with translucent sulfuric acid paper, cut off the wound part of the paper, put it on a balance and weigh it and convert it into an area. Wound healing rate=(original wound area-unhealed wound area)/original wound area×100%. The appearance of rat scald wound healing is shown in Figure 3. The pathological detection results are shown in Figure 4. The results of the wound healing rate are shown in Table 4.

Each experimental group rat wound healing rate of table 4 ( n=6)

As can be seen from Table 4, the healing effect of the traditional Chinese medicine liquid dressing of the present invention on rat scald wounds is close to that of the positive control group, and the difference has no statistical significance (P>0.05); on the 21st day, the wounds of the rats were healed substantially; The healing rate of the experimental group was significantly higher than that of the negative control group (P<0.01). The results of wound healing rate were consistent with the results of pathological examination. It can be seen from Figure 4 that in the later stage of wound healing, the skin keratin of the experimental group and the positive control group has been formed, and the hair follicles and hair follicle glands of the subcutaneous tissue are basically normal; while the epithelium of the negative control group is severely shed, and the hair follicle glands of the subcutaneous tissue appear large areas Necrosis, severe hyperplasia of fibrous tissue. Both the traditional Chinese medicine liquid dressing and the erythromycin of the invention can improve the pathological damage of rats, and can significantly promote healing of scalded wounds of rats.

Claims (8)

1. a Chinese medicinal liquor dressing, it is characterised in that include the raw material of following percentage by weight:

Described filmogen is polyvinyl alcohol or polyvinyl butyral resin；

Described solvent is distilled water or ethanol.

Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that include the raw material of following percentage by weight:

Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that include the raw material of following percentage by weight:

Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that the alcoholysis degree of described polyvinyl alcohol is 87.0- 89.0mol%, viscosity is 20.5-24.5mpa.s.

Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that the viscosity of described polyvinyl butyral resin is 15.0-35.0mpa.s, fourth aldehyde group content is 45.0-49.0%.

Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that described Rhizoma Coptidis extract is adopted and made with the following method Standby: Rhizoma Coptidis is pulverized, take its powder and join the ethanol solution that volume fraction is 60% infiltrates overnight, be heated to reflux afterwards carrying Take 3 times, filtered while hot, merge 3 filtrates, filtrate is concentrated postlyophilization, obtains Rhizoma Coptidis extract.

Chinese medicinal liquor dressing the most according to claim 1, it is characterised in that described Flos Lonicerae extract is adopted with the following method Preparation: pulverized by Flos Lonicerae, takes its powder and joins and infiltrate overnight in the ethanol solution that volume fraction is 60%, post-heating return Stream extracts 2 times, filtered while hot, and filtrate is concentrated postlyophilization, obtains Flos Lonicerae extract by merging filtrate.

8. the preparation method of the Chinese medicinal liquor dressing described in any one of claim 1-7, it is characterised in that comprise the following steps:

1) by filmogen heating for dissolving, stirring cooling；

2) weigh menthol, join in ethanol solution and dissolve；

3) weigh Rhizoma Coptidis extract, join in the ethanol solution that volume fraction is 60%-70% and dissolve；

4) weigh Flos Lonicerae extract, join in the ethanol solution that volume fraction is 60%-70% and dissolve；

5) by glycerol, menthol solutions, Rhizoma Coptidis extract solution and Flos Lonicerae extract solution, process it is added sequentially in proportion 1), in the filmogen solution in, it is stirred well to mix homogeneously；

6) fill, to obtain final product.