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CN106266023B - 一种治疗胃溃疡的药物及其制备方法 - Google Patents

一种治疗胃溃疡的药物及其制备方法 Download PDF

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CN106266023B
CN106266023B CN201610785268.XA CN201610785268A CN106266023B CN 106266023 B CN106266023 B CN 106266023B CN 201610785268 A CN201610785268 A CN 201610785268A CN 106266023 B CN106266023 B CN 106266023B
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彭舒怀
王林
易志红
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Da Jia Wei Kang Biopharmaceutical Co.,Ltd.
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Abstract

本发明涉及一种治疗胃溃疡的药物及其制备方法。本发明提供了一种治疗胃溃疡的药物包括如下重量组分：丁香油30‑45份、壳聚糖15‑25份、瓦楞子28‑36份、鸡蛋壳40‑60份、枯矾28‑38份、红景天2‑4份、水红花子25‑35份、珍珠粉0.2‑0.6份、仙鹤草100‑120份。本发明提供的治疗胃溃疡的药物，各种成分安全温和，可以有效增加药物在胃部的停留时间，具有养胃护胃的功效，并且对溃疡部位进行杀菌保护，长期服用能够根治胃溃疡。

Description

一种治疗胃溃疡的药物及其制备方法
技术领域
本发明属于中药领域，具体涉及一种治疗胃溃疡的药物及其制备方法。
背景技术
胃溃疡病或消化性溃疡是一种常见的消化道疾病，可发生于食管、胃或十二指肠，也可发生于胃-空肠吻合口附近或含有胃黏膜的Meckel憩室内，因为胃溃疡和十二指肠溃疡最常见，故一般所谓的消化性溃疡是指胃溃疡和十二指肠溃疡。它之所以称之为消化性溃疡，是因为既往认为胃溃疡和十二指肠溃疡是由于胃酸和胃蛋白酶对黏膜自身消化所形成的，事实上胃酸和胃蛋白酶只是溃疡形成的主要原因之一，还有其他原因可以形成消化性溃疡。由于胃溃疡和十二指肠溃疡的病因和临床症状有许多相似之处，有时难以区分是胃溃疡还是十二指肠溃疡，因此往往诊断为消化性溃疡，或胃、十二指肠溃疡。
现有的治疗胃溃疡的药物主要是通过含有钙质的原料来中和胃酸，这种方法实际上是缓解胃酸对伤口的侵蚀，但并非是治本之法，这对于患者而言，停止服用药物则会恢复原先的病况，尤其是对于慢性胃溃疡患者而言，此现象尤为明显。
发明内容
针对现有技术中的缺陷，本发明提供一种能养胃护胃、根除病患的治疗胃溃疡的药物及其制备方法。
为实现上述目的，本发明采用的技术方案是：
本发明提供了一种治疗胃溃疡的药物包括如下重量组分：丁香油30-45份、壳聚糖15-25份、瓦楞子28-36份、鸡蛋壳40-60份、枯矾28-38份、红景天2-4份、水红花子25-35份、珍珠粉0.2-0.6份、仙鹤草100-120份。
上述配方制得的药物无论对急性胃溃疡或者慢性胃溃疡均有更好的疗效，尤其适合慢性胃溃疡的治疗，经过长期的临床试验发现本发明提供药物适于患者长期服用，并且能够根治胃溃疡。
优选地，上述治疗胃溃疡的药物包括如下重量组分：丁香油35-45份、壳聚糖15-20份、瓦楞子30-35份、鸡蛋壳45-55份、枯矾30-35份、红景天2-4份、水红花子30-35份、珍珠粉0.3-0.6份、仙鹤草110-115份。
进一步优选地，上述治疗胃溃疡的药物包括如下重量组分：丁香油40份、壳聚糖16份、瓦楞子32份、鸡蛋壳48份、枯矾32份、红景天3份、水红花子32份、珍珠粉0.5份、仙鹤草112份。
优选地，上述治疗胃溃疡的药物中所述的壳聚糖的脱乙酰度为70-90％，分子量为80000-100000。
优选地，上述治疗胃溃疡的药物还包括5-10份蜜糖。所述蜜糖即为蜂蜜中提炼出的果糖，选用其作为甜味剂口感温和，且其同时具有降血压、护肝、缓解疼痛等作用，能够与上述药物进行配合增强药效，同时兼具护胃的功能。
优选地，上述治疗胃溃疡的药物中所述各组分为200-400目的粉末。
优选地，上述治疗胃溃疡的药物中所述各组分为400目的粉末。
如上所述的治疗胃溃疡的药物的制备方法包括步骤：
A.制仙鹤草清膏：将仙鹤草加水煎煮二次，每次2-3小时，合并煎液过滤，滤液静置24h，上清液浓缩至相对密度80-85℃为1.18-1.20的清膏；
B.制胶囊：将壳聚糖、瓦楞子、鸡蛋壳、枯矾、红景天、水红花子加清膏混合均匀制粒，干燥成颗粒，装入胶囊，再将丁香油加入胶囊即得产品。
优选地，上述的治疗胃溃疡的药物的制备方法中所述步骤B中丁香油加入胶囊后再将蜜糖加入胶囊得产品。
优选地，上述的治疗胃溃疡的药物的制备方法中所述步骤B中干燥成颗粒的温度不高于60℃。
综上所述，本发明提供的治疗胃溃疡的药物，各种成分安全温和，可以有效增加药物在胃部的停留时间，具有养胃护胃的功效，并且对溃疡部位进行杀菌保护，长期服用能够根治胃溃疡。
具体实施方式
下面结合具体实施例对本发明做进一步说明。所述实施例仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
实施例一
将112g仙鹤草加水煎煮二次，每次2小时，合并煎液过滤，滤液静置24h，上清液浓缩至相对密度80-85℃为1.18-1.20的清膏；
将预先粉碎成400目的下述组分加清膏混合均匀制粒：16g脱乙酰度为70％、分子量为80000的壳聚糖、32g瓦楞子、48g鸡蛋壳、32g枯矾、3g红景天、32g水红花子，干燥成颗粒，装入胶囊，再将丁香油加入胶囊，最后将蜜糖加入胶囊即得产品。所述丁香油总共40g，所用蜜糖总共10g，最后制备胶囊按比例灌装为每粒胶囊内含0.5g上述组合物。
实施例二
将120g仙鹤草加水煎煮二次，每次2.5小时，合并煎液过滤，滤液静置24h，上清液浓缩至相对密度80-85℃为1.18-1.20的清膏；
将预先粉碎成300目的下述组分加清膏混合均匀制粒：25g脱乙酰度为80％、分子量为90000的壳聚糖、36g瓦楞子、60g鸡蛋壳、38g枯矾、4g红景天、25g水红花子，干燥成颗粒，装入胶囊，再将丁香油加入胶囊，最后将蜜糖加入胶囊即得产品。所述丁香油总共30g，所用蜜糖总共5g，最后制备胶囊按比例灌装为每粒胶囊内含0.5g上述组合物。
实施例三
将100g仙鹤草加水煎煮二次，每次3小时，合并煎液过滤，滤液静置24h，上清液浓缩至相对密度80-85℃为1.18-1.20的清膏；
将预先粉碎成200目的下述组分加清膏混合均匀制粒：15g脱乙酰度为70％、分子量为100000的壳聚糖、28g瓦楞子、40g鸡蛋壳、28g枯矾、2g红景天、35g水红花子，干燥成颗粒，装入胶囊，再将丁香油加入胶囊即得产品。所述丁香油总共45g，最后制备胶囊按比例灌装为每粒胶囊内含0.5g上述组合物。
实施例四
将115g仙鹤草加水煎煮二次，第一次2小时，第二次3小时，合并煎液过滤，滤液静置24h，上清液浓缩至相对密度80-85℃为1.18-1.20的清膏；
将预先粉碎成400目的下述组分加清膏混合均匀制粒：20g脱乙酰度为90％、分子量为80000的壳聚糖、30g瓦楞子、45g鸡蛋壳、30g枯矾、4g红景天、35g水红花子，干燥成颗粒，装入胶囊，再将丁香油加入胶囊即得产品。所述丁香油总共35g，最后制备胶囊按比例灌装为每粒胶囊内含0.5g上述组合物。
实施例一至四制备的胶囊给患者口服，一次1粒，一日3次。共76人年龄分布在25-73岁，其中有62人为慢性胃溃疡患者，其余患者为服用了其它刺激药物后引发的急性胃溃疡患者。
临床结果为：慢性胃溃疡患者经过两个月服药后，溃疡症状明显减轻，经过一年服药后，有16名患者胃溃疡在后续一年半停药后内未复发，经过一年半服药后，有32名患者胃溃疡在后续一年内停药后未复发。急性胃溃疡患者在服药15天后均好转，继续服药一周后基本痊愈。

Claims (2)

1.一种治疗胃溃疡的药物的制备方法，其特征在于：所述治疗胃溃疡的药物包括如下重量组分：丁香油35-45份、壳聚糖15-20份、瓦楞子30-35份、鸡蛋壳45-55份、枯矾30-35份、红景天2-4份、水红花子30-35份、珍珠粉0.3-0.6份、仙鹤草110-115份；还包括5-10份蜜糖；所述的壳聚糖的脱乙酰度为70-90％，分子量为80000-100000；所述各组分为400目的粉末；
所述治疗胃溃疡的药物的制备方法，包括步骤：
A.制仙鹤草清膏：将仙鹤草加水煎煮二次，每次2-3小时，合并煎液过滤，滤液静置24h，上清液浓缩至相对密度80-85℃为1.18-1.20的清膏；
B.制胶囊：将壳聚糖、瓦楞子、鸡蛋壳、枯矾、红景天、水红花子加清膏混合均匀制粒，干燥成颗粒，装入胶囊，再将丁香油加入胶囊即得产品；
所述步骤B中丁香油加入胶囊后再将蜜糖加入胶囊得产品；
所述步骤B中干燥成颗粒的温度不高于60℃。
2.如权利要求1所述的制备方法制备的治疗胃溃疡的药物。
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