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CN105769830B - A kind of cooling emulsion and preparation method thereof - Google Patents

A kind of cooling emulsion and preparation method thereof Download PDF

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Publication number
CN105769830B
CN105769830B CN201610191815.1A CN201610191815A CN105769830B CN 105769830 B CN105769830 B CN 105769830B CN 201610191815 A CN201610191815 A CN 201610191815A CN 105769830 B CN105769830 B CN 105769830B
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polyethylene glycol
viscosity modifier
volume ratio
cooling
ethanol
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CN105769830A (en
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沈文
王兰
刘园
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Shaanxi University of Science and Technology
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Shaanxi University of Science and Technology
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
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    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82—Preparation or application process involves sonication or ultrasonication

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  • Dermatology (AREA)
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  • Cosmetics (AREA)

Abstract

The invention discloses a kind of cooling emulsions, including alcoholic solution, compound emulsifying agent and viscosity modifier, and wherein the volume ratio of alcoholic solution, compound emulsifying agent and viscosity modifier is 15~18:1:0.2~1.5.The invention also discloses preparation methods: emulsifying, obtains after alcoholic solution, compound emulsifying agent and viscosity modifier are mixed.The cooling emulsion that the present invention is prepared has good formability, can effectively be applied to each position of human skin in use, realizes cooling in the heat that skin is taken away in the volatilization of skin surface by high concentration alcohol；It is strong with stretchability, cooling is fast, does not injure skin, non-stimulated equal good effects.

Description

A kind of cooling emulsion and preparation method thereof
Technical field
The invention belongs to medical, daily cosmetics technical fields, and in particular to a kind of cooling emulsion, the invention further relates to this The preparation method of cooling emulsion.
Background technique
In the clinical treatment of fever patient, local skin Physical temperature-lowering is often effective mode, traditional ice Bath cooling can cause certain nerve stimulation to lack effective especially in the initial therapy of some local burn and scalds to patient Cooling material, patient often requires to use a large amount of ice water flushing or alcohol cleans cooling, causes inconvenient for use Deng obstacles, skin Long-time alcohol exposure will appear degreasing phenomenon again, and for low age or elderly patient, the stimulation of the ice baths such as alcohol can also cause discomfort Sense.Clinically used cooling patch cooling at present, again by usable floor area, sticking portion flatness, instead in the patch use that cools down The conditions such as notice again limitation, it is inconvenient for use.
Summary of the invention
The object of the present invention is to provide a kind of cooling emulsions, solve and exist in existing clinical or daily skin falling temperature technique Irritation it is big, skin is uncomfortable, skin degreasing, high temperature position poor flatness, it is inconvenient for use the problems such as.
It is a further object to provide a kind of preparation methods of emulsion that cools down.
The technical scheme adopted by the invention is that a kind of cooling emulsion, including alcoholic solution, compound emulsifying agent and viscosity-adjusting agent Agent, wherein the volume ratio of alcoholic solution, compound emulsifying agent and viscosity modifier is 15~18:1:0.2~1.5.
The features of the present invention also characterized in that
Alcoholic solution is formed by glycerol, ethyl alcohol and mixed with propylene glycol, wherein the volume ratio of glycerol, ethyl alcohol and propylene glycol be 1~ 1.5:4~2.5:1.
Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate mix compound emulsifying agent again, wherein Tween 80, Si Pan 80, polyoxyethylene nonylphenol ether and the mass ratio of ethyl hydroxy benzoate mixing are 5~20:27~5:1~2:1.
Viscosity modifier is mixed by one kind in Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 with ethyl alcohol It forms, wherein the mass volume ratio of Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 and ethyl alcohol is 3~7: 100。
Second technical solution of the present invention is a kind of preparation method for the emulsion that cools down, specifically according to following step It is rapid to implement:
Step 1, glycerol, ethyl alcohol and mixed with propylene glycol are obtained into alcoholic solution；By Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and hydroxyl Phenethyl ester is hybridly prepared into compound emulsifying agent；By one of Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 Sufficiently swelling obtains viscosity modifier at 30 DEG C~50 DEG C with ethyl alcohol；
Step 2, it is emulsified after alcoholic solution, compound emulsifying agent and viscosity modifier being mixed, obtains cooling emulsion.
The features of the present invention also characterized in that
The volume ratio of glycerol, ethyl alcohol and propylene glycol is 1~1.5:4~2.5:1 in step 1；Tween 80, Si Pan in step 1 80, the mass ratio of polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate is 5~20:27~5:1~2:1.
The mass volume ratio of Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 and ethyl alcohol is 3 in step 1 ~7:100.
The volume ratio of alcoholic solution, compound emulsifying agent and viscosity modifier is 15~18:1:0.2~1.5 in step 2.
Emulsification is under 20 DEG C~30 DEG C, the output power of 160~270W, in a manner of 5s ultrasound interval 2s in step 2 3~5min of ultrasonic emulsification.
Emulsification is emulsified in a manner of churned mechanically under 20 DEG C~30 DEG C, the output power of 100~150W in step 2 10~15min.
The invention has the advantages that the cooling emulsion that the present invention is prepared has good formability, using Cheng Zhongneng is effectively applied to each position of human skin, and the heat for taking away skin in the volatilization of skin surface by high concentration alcohol is real Now cool down；It is strong with stretchability, cooling is fast, does not injure skin, non-stimulated equal good effects.
Detailed description of the invention
Fig. 1 is present invention cooling emulsion and commercially available hydrogel temperature-reducing patch effect contrast figure.
Specific embodiment
The following describes the present invention in detail with reference to the accompanying drawings and specific embodiments.
A kind of cooling emulsion of the present invention, including alcoholic solution, compound emulsifying agent and viscosity modifier, wherein alcoholic solution, compound The volume ratio of emulsifier and viscosity modifier is 15~18:1:0.2~1.5.
Alcoholic solution is formed by glycerol, ethyl alcohol and mixed with propylene glycol, wherein the volume ratio of glycerol, ethyl alcohol and propylene glycol be 1~ 1.5:4~2.5:1.
Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate mix compound emulsifying agent again, wherein Tween 80, Si Pan 80, polyoxyethylene nonylphenol ether and the mass ratio of ethyl hydroxy benzoate mixing are 5~20:27~5:1~2:1.
Viscosity modifier is mixed by one kind in Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 with ethyl alcohol It forms, wherein the mass volume ratio of Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 and ethyl alcohol is 3~7: 100。
The preparation method of above-mentioned cooling emulsion, is specifically implemented according to the following steps:
It step 1, is that 1~1.5:4~2.5:1 is mixed to get alcoholic solution with volume ratio by glycerol, ethyl alcohol and propylene glycol；
Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate are mixed with mass ratio for 5~20:27~5:1~2:1 and matched Compound emulsifying agent is made；
By one of Macrogol 6000, Macrogol 4000 or polyethylene glycol 12000 and ethyl alcohol with mass volume ratio For 3~7:100, sufficiently swelling obtains viscosity modifier at 30 DEG C~50 DEG C；
Step 2, after alcoholic solution, compound emulsifying agent and viscosity modifier being mixed under the output power of 160~270W, with Mode 3~5min of ultrasonic emulsification of 5s ultrasound interval 2s obtains cooling emulsion；
Or after mixing alcoholic solution, compound emulsifying agent and viscosity modifier under the output power of 100~150W, with machinery The mode of stirring emulsifies 10~15min, obtains cooling emulsion.
Cooling emulsion according to the present invention is obtained with compound emulsifying agent oil emulsion phase middle and high concentration alcohol, utilizes Tu Zhanhou The heated volatilization of high concentration alcohol reduces the amount of localized heat for applying exhibition position, and using conveniently, comfortably, stretchability is good, no skin irritation, It can achieve the effect of fast cooling.
Application example 1
User Liu, people from Xianyang, outer auricle inflammation cause skin to generate heat, can not since outer auricle protrusion is more Temperature-reducing paste is attached, present invention cooling emulsion is used.Good using rear local experiences, mild non-stimulated, cooling impression is obvious.
Application example 2
User Mr. Wang, people from Tianjin, since sunlight irradiation time is long, Head And Face overheat, can not since head hair is excessive Temperature-reducing paste is attached, and the cleaning of local wound ice bath is inconvenient, therefore present invention cooling emulsion is used to apply scalp at exhibition head hair, used Impression is good afterwards, and cooling effect is obvious, reduces the inconvenience being cleaned multiple times.
It is that tested group of carry out hand skin of back applies exhibition this cooling emulsion and general commercially available water with 20-50 years old 20 people of different sexes Gel temperature-reducing paste, alcohol compare subjective appreciation, compare marking with 10 points for full marks, average are calculated, as a result such as 1 institute of table Show.
The cooling of table 1 patch, hydrogel temperature-reducing plaster and alcohol marking result
Project Comfort Cooling sense Comfort level Irritation
Cool down emulsion 9.5 8.75 9.8 0.6
Hydrogel temperature-reducing plaster 9.5 6.8 9.7 0.5
Alcohol 6.75 9.9 8.9 5.3
As can be seen from Table 1 the present invention cooling emulsion in terms of comfort, comfort level, irritation all with hydrogel temperature-reducing It pastes equally matched, and is substantially better than hydrogel temperature-reducing plaster in terms of the sense that cools down.Exhibition alcohol, attaching hydrogel temperature-reducing plaster are comprehensive with applying Comparison, in the aforementioned coating range of synthesis, present invention cooling emulsion has a clear superiority in all respects.
Hot plate cooling is carried out using present invention cooling emulsion and commercially available Common hydrogels temperature-reducing paste to compare, and it is initial to adjust hot plate Temperature is 37 DEG C, and the attaching time is 10min, records final temperature.
As can see from Figure 1 in hot plate is identical using the time, using temperature as ordinate, the time is as abscissa In coordinate system, the temperature drop time section gradient for the emulsion that cools down is greater than Common hydrogels temperature-reducing paste, that is to say, that cool down emulsion Overall rate of temperature fall (rate of temperature fall=temperature depreciation/time) is greater than hydrogel temperature-reducing patch.And cooling emulsion applies 10 points of exhibition The final hot plate temperature reached after clock be lower than hydrogel temperature-reducing plaster final hot plate temperature, illustrate cool down emulsion cooling degree with Hydrogel temperature-reducing plaster is better than in cooling rate.
Embodiment 1
It is that 1:4:1 measurement glycerol, ethyl alcohol and mixed with propylene glycol are uniform with volume ratio, obtains alcoholic solution；
It is that 5:27:1:1 takes Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate to prepare compound emulsifying agent with mass ratio；
It is that 3:100 taking polyethylene glycol 6000 and ethyl alcohol are sufficiently swollen at 30 DEG C with mass volume ratio, obtains viscosity-adjusting agent Agent；
It is 15:1:0.2 at 20 DEG C by alcoholic solution, compound emulsifying agent and viscosity modifier volume ratio, and in the defeated of 160W Out under power, the ultrasonic emulsification 3min in a manner of 5s ultrasound interval 2s obtains cooling emulsion.
Embodiment 2
It is that 1.5:2.5:1 measurement glycerol, ethyl alcohol and mixed with propylene glycol are uniform with volume ratio, obtains alcoholic solution；
It is that 20:5:2:1 takes Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate to prepare compound emulsifying agent with mass ratio；
With mass volume ratio for 7:100 taking polyethylene glycol 4000: ethyl alcohol is sufficiently swollen at 50 DEG C, obtains viscosity-adjusting agent Agent；
It is 18:1:1.5 at 30 DEG C by alcoholic solution, compound emulsifying agent and viscosity modifier volume ratio, and in the defeated of 270W Out under power, the ultrasonic emulsification 5min in a manner of 5s ultrasound interval 2s obtains cooling emulsion.
Embodiment 3
It is that 1.2:3:1 measurement glycerol, ethyl alcohol and mixed with propylene glycol are uniform with volume ratio, obtains alcoholic solution；
It is that 10:18:1.5:1 takes Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate to prepare composite emulsifying with mass ratio Agent；
With mass volume ratio for 5:100 taking polyethylene glycol 12000: ethyl alcohol is sufficiently swollen at 40 DEG C, obtains viscosity-adjusting agent Agent；
It is 16:1:1 at 30 DEG C by alcoholic solution, compound emulsifying agent and viscosity modifier volume ratio, and in the output of 220W Under power, the ultrasonic emulsification 4min in a manner of 5s ultrasound interval 2s obtains cooling emulsion.
Embodiment 4
It is that 1:4:1 measurement glycerol, ethyl alcohol and mixed with propylene glycol are uniform with volume ratio, obtains alcoholic solution；
It is that 5:27:1:1 takes Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate to prepare compound emulsifying agent with mass ratio；
It is that 3:100 taking polyethylene glycol 6000 and ethyl alcohol are sufficiently swollen at 30 DEG C with mass volume ratio, obtains viscosity-adjusting agent Agent；
It is 15:1:0.2 at 20 DEG C by alcoholic solution, compound emulsifying agent and viscosity modifier volume ratio, and in the defeated of 100W Out under power, 10min is emulsified in a manner of churned mechanically and obtains cooling emulsion.
Embodiment 5
It is that 1.5:2.5:1 measurement glycerol, ethyl alcohol and mixed with propylene glycol are uniform with volume ratio, obtains alcoholic solution；
It is that 20:5:2:1 takes Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate to prepare compound emulsifying agent with mass ratio；
It is that 7:100 taking polyethylene glycol 4000 and ethyl alcohol are sufficiently swollen at 50 DEG C with mass volume ratio, obtains viscosity-adjusting agent Agent；
It is 18:1:1.5 at 30 DEG C by alcoholic solution, compound emulsifying agent and viscosity modifier volume ratio, and in the defeated of 150W Out under power, 15min is emulsified in a manner of churned mechanically and obtains cooling emulsion.
Embodiment 6
It is that 1.2:3:1 measurement glycerol, ethyl alcohol and mixed with propylene glycol are uniform with volume ratio, obtains alcoholic solution；
It is that 10:18:1.5:1 takes Tween 80, this Pan 80, polyoxyethylene nonylphenol ether and ethyl hydroxy benzoate to prepare composite emulsifying with mass ratio Agent；
It is that 5:100 taking polyethylene glycol 12000 and ethyl alcohol are sufficiently swollen at 40 DEG C with mass volume ratio, obtains viscosity-adjusting agent Agent；
It is 16:1:1 at 30 DEG C by alcoholic solution, compound emulsifying agent and viscosity modifier volume ratio, and in the output of 120W Under power, 13min is emulsified in a manner of churned mechanically and obtains cooling emulsion.

Claims (6)

1.一种降温乳剂，其特征在于，包括醇溶液、复合乳化剂和粘度调节剂，其中醇溶液、复合乳化剂和粘度调节剂的体积比为15～18：1：0.2～1.5，所述醇溶液由甘油、乙醇和丙二醇混合而成，其中甘油、乙醇和丙二醇的体积比为1～1.5：4～2.5：1，所述复合乳化剂由吐温80、斯潘80、乳化剂OP和羟苯乙酯混合而成，其中吐温80、斯潘80、乳化剂OP和羟苯乙酯混合的质量比为5～20：27～5：1～2：1，所述粘度调节剂由聚乙二醇6000、聚乙二醇4000或聚乙二醇12000中一种与乙醇混合而成，其中聚乙二醇6000、聚乙二醇4000或聚乙二醇12000与乙醇的质量体积比为3～7：100；1. a cooling emulsion, is characterized in that, comprises alcohol solution, composite emulsifier and viscosity modifier, wherein the volume ratio of alcohol solution, composite emulsifier and viscosity modifier is 15～18:1:0.2～1.5, described The alcoholic solution is formed by mixing glycerol, ethanol and propylene glycol, wherein the volume ratio of glycerol, ethanol and propylene glycol is 1-1.5:4-2.5:1, and the composite emulsifier is composed of Tween 80, Span 80, emulsifier OP and Ethyl hydroxybenzoate is mixed, wherein the mass ratio of Tween 80, Span 80, emulsifier OP and ethyl hydroxybenzoate is 5-20:27-5:1-2:1, and the viscosity modifier is composed of One of polyethylene glycol 6000, polyethylene glycol 4000 or polyethylene glycol 12000 is mixed with ethanol, wherein the mass volume ratio of polyethylene glycol 6000, polyethylene glycol 4000 or polyethylene glycol 12000 and ethanol 3～7:100; 所述降温乳剂通过以下步骤制备：The cooling emulsion is prepared by the following steps: 步骤1，将甘油、乙醇和丙二醇混合得到醇溶液；将吐温80、斯潘80、乳化剂OP和羟苯乙酯混合配制成复合乳化剂；将聚乙二醇6000、聚乙二醇4000或聚乙二醇12000中的一种和乙醇在30℃～50℃下充分溶胀得到粘度调节剂；Step 1, glycerin, ethanol and propylene glycol are mixed to obtain an alcohol solution; Tween 80, Span 80, emulsifier OP and ethyl paraben are mixed to prepare a composite emulsifier; polyethylene glycol 6000, polyethylene glycol 4000 Or one of polyethylene glycol 12000 and ethanol are fully swollen at 30°C to 50°C to obtain a viscosity modifier; 步骤2，将醇溶液、复合乳化剂和粘度调节剂混合后乳化得到降温乳剂；醇溶液、复合乳化剂和粘度调节剂的体积比为15～18：1：0.2～1.5；乳化是在20℃～30℃、160～270W的输出功率下，以5s超声间歇2s的方式超声乳化3～5min。Step 2, mixing the alcohol solution, the composite emulsifier and the viscosity modifier, and emulsification to obtain a cooling emulsion; the volume ratio of the alcohol solution, the composite emulsifier and the viscosity modifier is 15-18:1:0.2-1.5; the emulsification is performed at 20°C ～30℃, under the output power of 160～270W, phacoemulsification was carried out for 3～5min with 5s ultrasonic interval for 2s. 2.一种权利要求1所述的降温乳剂的制备方法，其特征在于，具体按照以下步骤实施：2. a preparation method of the cooling emulsion according to claim 1, is characterized in that, specifically implements according to the following steps: 步骤1，将甘油、乙醇和丙二醇混合得到醇溶液；将吐温80、斯潘80、乳化剂OP和羟苯乙酯混合配制成复合乳化剂；将聚乙二醇6000、聚乙二醇4000或聚乙二醇12000中的一种和乙醇在30℃～50℃下充分溶胀得到粘度调节剂；Step 1, glycerin, ethanol and propylene glycol are mixed to obtain an alcohol solution; Tween 80, Span 80, emulsifier OP and ethyl paraben are mixed to prepare a composite emulsifier; polyethylene glycol 6000, polyethylene glycol 4000 Or one of polyethylene glycol 12000 and ethanol are fully swollen at 30°C to 50°C to obtain a viscosity modifier; 步骤2，将醇溶液、复合乳化剂和粘度调节剂混合后乳化，得到降温乳剂。In step 2, the alcohol solution, the composite emulsifier and the viscosity modifier are mixed and emulsified to obtain a cooling emulsion. 3.根据权利要求2所述的降温乳剂的制备方法，其特征在于，步骤1中甘油、乙醇和丙二醇的体积比为1～1.5：4～2.5：1；步骤1中吐温80、斯潘80、乳化剂OP和羟苯乙酯的质量比为5～20：27～5：1～2：1。3. the preparation method of cooling emulsion according to claim 2, is characterized in that, in step 1, the volume ratio of glycerol, ethanol and propylene glycol is 1～1.5:4～2.5:1; 80. The mass ratio of emulsifier OP and ethyl paraben is 5-20:27-5:1-2:1. 4.根据权利要求2或3所述的降温乳剂的制备方法，其特征在于，步骤1中聚乙二醇6000、聚乙二醇4000或聚乙二醇12000和乙醇的质量体积比为3～7：100。4. the preparation method of the cooling emulsion according to claim 2 or 3, is characterized in that, in step 1, the mass volume ratio of polyethylene glycol 6000, polyethylene glycol 4000 or polyethylene glycol 12000 and ethanol is 3～ 7:100. 5.根据权利要求2所述的降温乳剂的制备方法，其特征在于，步骤2中醇溶液、复合乳化剂和粘度调节剂的体积比为15～18：1：0.2～1.5。5 . The method for preparing a cooling emulsion according to claim 2 , wherein the volume ratio of the alcohol solution, the composite emulsifier and the viscosity modifier in step 2 is 15-18:1:0.2-1.5. 6 . 6.根据权利要求2或5所述的降温乳剂的制备方法，其特征在于，步骤2中乳化是在20℃～30℃、160～270W的输出功率下，以5s超声间歇2s的方式超声乳化3～5min。6. The preparation method of the cooling emulsion according to claim 2 or 5, characterized in that, in step 2, emulsification is carried out at 20°C～30°C, under the output power of 160～270W, with 5s ultrasonic intermittent 2s mode phacoemulsification 3 to 5 minutes.
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Publication number Priority date Publication date Assignee Title
CN101190182A (en) * 2006-12-01 2008-06-04 北京大学 self-microemulsifying composition
CN102716043A (en) * 2012-06-29 2012-10-10 金红叶纸业集团有限公司 Cool and refreshing emulsion and moist towelette

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DE10049707A1 (en) * 2000-10-07 2002-04-11 Sms Demag Ag Cooling element used in blast furnaces comprises a region through which the coolant passes with an arrangement of internal coolant-conveying channels extending via a mouth region of tubular pieces into the edge region of the cooling element

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101190182A (en) * 2006-12-01 2008-06-04 北京大学 self-microemulsifying composition
CN102716043A (en) * 2012-06-29 2012-10-10 金红叶纸业集团有限公司 Cool and refreshing emulsion and moist towelette

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