CN105213419A - A kind of composite multifunctional hand-cleaning disinfectant - Google Patents
A kind of composite multifunctional hand-cleaning disinfectant Download PDFInfo
- Publication number
- CN105213419A CN105213419A CN201410237448.5A CN201410237448A CN105213419A CN 105213419 A CN105213419 A CN 105213419A CN 201410237448 A CN201410237448 A CN 201410237448A CN 105213419 A CN105213419 A CN 105213419A
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- China
- Prior art keywords
- isopropyl alcohol
- ethanol
- oxireme
- disinfectant
- component
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 16
- 238000004140 cleaning Methods 0.000 title abstract description 5
- 239000002131 composite material Substances 0.000 title abstract description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 37
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- MFLYTCSVJYYAOR-UHFFFAOYSA-N (carbamimidoylazaniumyl)formate Chemical compound NC(=N)NC(O)=O MFLYTCSVJYYAOR-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 8
- 229940046009 vitamin E Drugs 0.000 claims abstract description 8
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 8
- 239000011709 vitamin E Substances 0.000 claims abstract description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 7
- 239000008213 purified water Substances 0.000 claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 239000000839 emulsion Substances 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims abstract description 3
- 230000004044 response Effects 0.000 claims abstract description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 description 10
- 241000700605 Viruses Species 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- -1 carboxy guanidine alcohols Chemical class 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
A kind of composite multifunctional hand-cleaning disinfectant, formula (component and percentage by weight % thereof): oxireme carboxy guanidine, 13-26.5; Ethanol, 34-56; Isopropyl alcohol, 10.5-15.5; Polyacrylic acid, 0.25-1.0; Triethanolamine, 0.5-1.5; Methyl glucoside-20,0.6-1.0; Glycerol, 0.2-1.0; Vitamin E, 0.2-0.5; Purified water, adds to 100.Following step: described component mixes by proportioning by (1) except ethanol, isopropyl alcohol, reacts a program in emulsion reaction tank; (2), behind question response liquid cooling to 30 ~ 40 DEG C, add ethanol, isopropyl alcohol dissolve after subpackage.
Description
Technical field
The present invention relates to a kind of professional disinfectant of hands, especially effective ingredient is oxireme carboxy guanidine alcohols hand-cleaning disinfectant and preparation method thereof.For sterilizing and the skin protection of mucocutaneous, the body surface hands of various occasion, every field, various age people.
Background technology
The professional disinfectant kind of existing hands is a lot, and bactericidal property differs, and has dividing of high, medium and low effect.The valid density of high effect disinfectants is also high often, and cost price is also high.And existing disinfectant poor stability, toxic, corrosivity and penetrating odor, the skin of opponent has certain damage, also has certain pollution to environment, and the hands after sterilization also needs a large amount of water to rinse.Therefore, people wish to have a kind of i.e. sterilizing skin-protective but also safety and stability and the composite multifunction disinfectant of professional hands without the need to water always.
Summary of the invention
The object of the present invention is to provide a kind of professional disinfectant that can overcome the hands of existing procucts deficiency, belong to nontoxic, colourless, tasteless, non-stimulated, corrosion-free, free of contamination food grade products, there is efficient, low concentration, good stability, rinse without the need to water, the feature that easy to carry, sterilizing skin-protective function is many.
Main points of the present invention are to select suitable component, and carry out rational mixture, form a kind of oxireme carboxy guanidine alcohols hand-cleaning disinfectant through emulsion reaction.
The formula that the present invention selects following (component and percentage by weight % thereof): oxireme carboxy guanidine 13-26.5 ethanol 34-56 isopropyl alcohol 10.5-15.5 polyacrylic acid 0.25-1.0 triethanolamine 0.5-1.5 methyl glucoside-200.6-1.0 glycerol 0.2-1.0 vitamin E 0.2-0.5 purified water adds to 100.
Oxireme carboxy guanidine is as main sterilization component, guanidine radicals in this component has very high activity in the polymerization, polymeric derivative is made to be electropositive, therefore be easy to by usually in electronegative each bacterioid, virus adsorb, thus inhibit the splitting function of antibacterial, virus, make antibacterial, virus loses reproductive function, in addition the thin film that formed of polymer, plug the respiration channel of microorganism, microorganism is choked to death.
Ethanol and isopropyl alcohol add in mixture as main sterilization component solvent, be combined, polymer is easier to and each bacterioid, viruses adsorption by hydrogen bond with the solute containing aerobic nitrogen.Its mechanism of action is the concurrent disinfection of ethanol and isopropyl alcohol, has extremely strong degeneration dehydration, and the space that alcohol molecule enters protein peptide chain makes tropina degeneration or precipitation.Alcohols can disturb the metabolism of microorganism simultaneously, inhibits antibacterial Fast-propagation.Alcohols can make the cell wall lysis of bacterial virus, and alcohol molecule enters endochylema rapidly, the breathing of antibacterial and enzyme system is destroyed, makes antibacterial and virus at once dead, thus serve extremely strong bactericidal action.The volatility of ethanol and isopropyl alcohol is extremely strong, dry and comfortable rapidly after making to hand-wash.
Polyacrylic acid, triethanolamine, add in mixture in proportion, object is by its characteristic, the viscosity of disinfectant solution is improved in colloidal, and the very fast surface at hands forms one deck colourless transparent film, adds long-term fungistatic effect.
Glycerol, vitamin E, methyl glucoside, add in mixture in proportion, object has nourishing and moisture-keeping function by its characteristic to skin.
The preparation method of product of the present invention is:
(1) by proportioning, described component is mixed except ethanol, isopropyl alcohol, in emulsion reaction tank, react a program.
(2) question response liquid cooling to 30 ~ 40 DEG C add ethanol, isopropyl alcohol dissolve be mixed after subpackage.
The present invention compares with existing hand disinfectant has advantage: (1) sterilization and disinfection Be very effective, through experiment, this product to escherichia coli, staphylococcus aureus, Candida albicans, bacillus subtilis black variety bud cell, 1 minute, sterilizing rate can reach 100%; To virus, take hepatitis B virus as role of delegate 2 minutes, sterilizing rate can reach 100%.(2) nontoxic, colourless, tasteless, non-stimulated, non-corrosiveness.Contained various Toxic is all lower than physics and chemistry health limitation national standard after measured.To animal toxicology experiment, do not produce adverse consequences.Belong to foodstuffs without toxicity level disinfectant.Be suitable for various occasion, every field, the sterilizing of mucocutaneous, body surface hands of various age people and skin protection.(3) this product is macromolecular colloidal polymer, chemical property is very stable, after testing, 54 DEG C in two weeks, effective ingredient rate of descent < 3%, 37 DEG C, 3 months effective ingredient rate of descent < 4%, room temperature places 1 year, effective ingredient decline < 6%.(4) without the need to water rinse, easy to carry.(5) technique is simple, and cost is low.
Below in conjunction with embodiment, the present invention is described in further detail:
According to sterilizing and the skin protection requirement of mucocutaneous, the body surface hands of different occasions, different fields, all ages and classes people, be configured according to data listed in Table (percentage by weight %) and described step thereof:
Tables of data:
Formula one: oxireme carboxy guanidine 25-25.5 ethanol 45-55.5 isopropyl alcohol 13.5-15.5 polyacrylic acid 0.5-1.0 triethanolamine 0.5-1.0 methyl glucoside-200.5-1.0 glycerol 0.5-1.0 vitamin E 0.25-0.5 purified water adds to 100.
Formula two: oxireme carboxy guanidine 20-21.5 ethanol 35-45.5 isopropyl alcohol 11.5-13.5 polyacrylic acid 0.2-0.5 triethanolamine 0.2-0.5 methyl glucoside-200.5-0.8 glycerol 0.2-0.6 vitamin E 0.25-0.5 purified water adds to 100.
Formula three: oxireme carboxy guanidine 25-26.5 ethanol 34-48.5 isopropyl alcohol 10.5-14.5 polyacrylic acid 0.1-0.5 triethanolamine 0.1-0.5 methyl glucoside-200.6-0.8 glycerol 0.5-0.7 vitamin E 0.2-0.5 purified water adds to 100.
Formula four: oxireme carboxy guanidine 13-13.5 ethanol 55-56 isopropyl alcohol 10.5-11.0 polyacrylic acid 0.3-0.8 triethanolamine 1.0-1.5 methyl glucoside-200.5-0.8 glycerol 0.4-0.8 vitamin E 0.2-0.3 purified water adds to 100.
Claims (2)
1., using oxireme carboxy guanidine, ethanol and isopropyl alcohol as the agent of the hands of main disinfectant component specialty disinfecting skin-care, it is characterized in that there is following formula (component and percentage by weight % thereof): oxireme carboxy guanidine 13-26.5 ethanol 34-56 isopropyl alcohol 10.5-15.5 polyacrylic acid 0.25-1.0 triethanolamine 0.5-1.5 methyl glucoside-200.6-1.0 glycerol 0.2-1.0 vitamin E 0.2-0.5 purified water adds to 100.
2. a preparation method for hands specialty disinfecting skin-care disinfectant described in claim 1, is characterized in that having following step: described component mixes by proportioning by (1) except ethanol, isopropyl alcohol, in emulsion reaction tank, reacts a program; (2), behind question response liquid cooling to 30 ~ 40 DEG C, add ethanol, isopropyl alcohol dissolve after subpackage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410237448.5A CN105213419A (en) | 2014-05-31 | 2014-05-31 | A kind of composite multifunctional hand-cleaning disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410237448.5A CN105213419A (en) | 2014-05-31 | 2014-05-31 | A kind of composite multifunctional hand-cleaning disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105213419A true CN105213419A (en) | 2016-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410237448.5A Pending CN105213419A (en) | 2014-05-31 | 2014-05-31 | A kind of composite multifunctional hand-cleaning disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105213419A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769592A (en) * | 2016-05-20 | 2016-07-20 | 蔡华英 | Sterilizing hand detergent |
| CN106172396A (en) * | 2016-07-21 | 2016-12-07 | 南通佰能油化有限公司 | Multifunctional hand-cleaning disinfectant |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1399887A (en) * | 2001-07-26 | 2003-03-05 | 李孟刚 | Guanidine alcohol composite multifunctional hand-cleaning disinfectant |
| CN101766181A (en) * | 2009-01-07 | 2010-07-07 | 陈新明 | Multifunctional disinfectant |
-
2014
- 2014-05-31 CN CN201410237448.5A patent/CN105213419A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1399887A (en) * | 2001-07-26 | 2003-03-05 | 李孟刚 | Guanidine alcohol composite multifunctional hand-cleaning disinfectant |
| CN101766181A (en) * | 2009-01-07 | 2010-07-07 | 陈新明 | Multifunctional disinfectant |
Non-Patent Citations (1)
| Title |
|---|
| 李东光 等: "《精细化学品配方（三）》", 31 August 2006, 江苏科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769592A (en) * | 2016-05-20 | 2016-07-20 | 蔡华英 | Sterilizing hand detergent |
| CN106172396A (en) * | 2016-07-21 | 2016-12-07 | 南通佰能油化有限公司 | Multifunctional hand-cleaning disinfectant |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160106 |