CN104663701A - Dinotefuran synergistic suspending agent and preparation method thereof - Google Patents
Dinotefuran synergistic suspending agent and preparation method thereof Download PDFInfo
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- CN104663701A CN104663701A CN201510034620.1A CN201510034620A CN104663701A CN 104663701 A CN104663701 A CN 104663701A CN 201510034620 A CN201510034620 A CN 201510034620A CN 104663701 A CN104663701 A CN 104663701A
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- agent
- mti
- suspending agent
- synergist
- dinotefuran
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- 239000000375 suspending agent Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- YKBZOVFACRVRJN-UHFFFAOYSA-N dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 title abstract description 9
- 230000002195 synergetic effect Effects 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 28
- 239000003755 preservative agent Substances 0.000 claims abstract description 16
- 230000002335 preservative effect Effects 0.000 claims abstract description 16
- 239000002562 thickening agent Substances 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims description 31
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 17
- 239000013530 defoamer Substances 0.000 claims description 14
- 239000006185 dispersion Substances 0.000 claims description 13
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical group CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- 229920001285 xanthan gum Polymers 0.000 claims description 9
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 238000003801 milling Methods 0.000 claims description 8
- 239000004576 sand Substances 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims description 8
- 239000004299 sodium benzoate Substances 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229940008099 dimethicone Drugs 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920000570 polyether Polymers 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 230000000749 insecticidal effect Effects 0.000 abstract description 10
- 238000012360 testing method Methods 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 7
- 239000002518 antifoaming agent Substances 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 4
- 230000000361 pesticidal effect Effects 0.000 abstract description 2
- 239000002270 dispersing agent Substances 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000009736 wetting Methods 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 1
- 238000010008 shearing Methods 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 description 19
- 230000000694 effects Effects 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- 239000007921 spray Substances 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 244000037666 field crops Species 0.000 description 7
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 5
- 150000002191 fatty alcohols Chemical class 0.000 description 5
- 241000176086 Sogatella furcifera Species 0.000 description 4
- 241000018137 Trialeurodes vaporariorum Species 0.000 description 4
- 230000002528 anti-freeze Effects 0.000 description 4
- 239000007900 aqueous suspension Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
- 241001124076 Aphididae Species 0.000 description 3
- 235000006008 Brassica napus var napus Nutrition 0.000 description 3
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 3
- 241001674939 Caulanthus Species 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000004009 herbicide Substances 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001966 tensiometry Methods 0.000 description 2
- QYYMDNHUJFIDDQ-UHFFFAOYSA-N 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one Chemical compound CN1SC=CC1=O.CN1SC(Cl)=CC1=O QYYMDNHUJFIDDQ-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241001600408 Aphis gossypii Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical group O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229960004011 methenamine Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- YZHUMGUJCQRKBT-UHFFFAOYSA-M sodium chlorate Chemical compound [Na+].[O-]Cl(=O)=O YZHUMGUJCQRKBT-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a dinotefuran synergistic suspending agent which is prepared from the following components in percentage by weight: 20-50% of dinotefuran, 2-5% of a dissolution inhibitor, 5-8% of a wetting dispersing agent, 0.1-1% of a thickener, 0.1% of a preservative, 3-5% of an anti-freezing agent, 0.1% of an antifoaming agent, 2-5% of a synergist and the balance being water. The preparation method comprises the following steps: premixing and shearing the dinotefuran, the dissolution inhibitor, the wetting dispersing agent, the thickener, the preservative, the antifreezing agent, the antifoaming agent, the synergist and water; and carrying out secondary sanding to form the product. The dinotefuran synergistic suspending agent provided by the invention is low in surface tension, high in pesticide effect, and adopts a simple preparation technology and simple application method; and a field test proves that the dinotefuran synergistic suspending agent provided by the invention has significant insecticidal efficacy.
Description
Technical field
The invention belongs to pesticide production technology field, be specifically related to a kind of MTI-446 synergy suspending agent and preparation method thereof.
Background technology
The third generation nicotinic insecticide that MTI-446 (dinotefuran) is developed for Mitsui chemical company.This medicament has remarkable interior suction osmosis, and namely shows very high insecticidal activity at very low dosage.This medicine insecticidal spectrum is wide, can prevent the various insects such as various Semiptera, Lepidoptera, diptera, orthoptera, Hymenoptera, beetle order.This medicament is fool proof to mammal, birds and aquatile, to crop without poisoning, can be used for numerous crops such as paddy rice, fruit tree, vegetables.
Modern change is very fast, just towards the future development of environmental type, suspending agent (SC) is being exactly wherein a kind of, and agricultural chemicals suspension agent is that in pesticidal preparations, developing history is short, very fast a kind of formulation, many weed killer herbicides, insecticidal bactericide can be processed into this formulation.Agricultural chemicals suspension agent take water as dispersion medium, insoluble or be slightly soluble in water the former medicine of solid through grinding, and by the effect of surfactant and other auxiliary agent, make it dispersed, the more stable liquid-solid state system that form the tiny higher suspension of a kind of particle, can flow, compared with missible oil, can avoid using a large amount of organic solvents; Compared with wettable powder, then to disperse drift without dust; To the toxicity of people and animals and excitant all lower; And the poisoning that can alleviate crop; Also can not burn in storage transportation because of organic solvent, safety is higher; Quite low degree is reduced to the danger that user and whole environment cause.Further, agricultural chemicals suspension agent excellent performance, good dispersion, suspensibility is high, puts forth effort with adhesion strength all stronger, resistance of rainwater washing against in the exhibition on plant corpus surface, and drug effect significantly and also more lasting.Insecticides adjuvant domestic is not at present also very flourishing, also has no small gap compared with developed countries, the problem that the suspending agent be made into existing auxiliary agent existence more or less in physical stability is certain.
Chinese invention patent CN12239829A is open, and " water complements to 100% for a kind of MTI-446 suspending agent and preparation method thereof: a kind of dinotefuran aqueous suspension agent of this disclosure of the invention; by weight percentage; comprise following component: the former medicine 5% ~ 40% of MTI-446; suspension aid 0 ~ 6%, surfactant 2% ~ 20%, thickener 0 ~ 1%; defoamer 0 ~ 1%; preservative 0 ~ 1%, antifreezing agent 0.5% ~ 5%; Described suspension aid is white carbon, bentonite, Magnesiumaluminumsilicate or kaolin; Described surfactant is NP, 500#, polycarboxylate, TWEEN, 600P, any mixing of 1 ~ 5 kind in thermally coupled distillation columns salt; Described thickener is xanthans, carboxymethyl cellulose, polyacrylamide or polyvinyl alcohol; Described defoamer is silicone defoaming agent, tributyl phosphate or butanols; Described preservative is formaldehyde, benzoic acid, Kathon CG or methenamine; Described antifreezing agent is ethylene glycol, glycerine, urea, isopropyl alcohol or propane diols ".This patent preparation process does not add synergist, can only play the general effect of preparation, and this invention does not add resistance solvent and cannot prepare high-load MTI-446 suspending agent in addition.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of MTI-446 synergy suspending agent and preparation method thereof, solve a preparation difficult problem for high-load MTI-446 suspending agent, improve the control efficiency of MTI-446 suspending agent by adding synergist, there is economy and environment double benefit.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of MTI-446 synergy suspending agent, be made up of following component by weight percentage: MTI-446 20%-50%, resistance solvent 2%-5%, dispersion moisture agent 5%-8%, thickener 0.1%-1%, preservative 0.1%, antifreezing agent 3%-5%, defoamer 0.1%, synergist 2%-5%, Yu Weishui.
Further, described resistance solvent is 5# white oil; Described dispersion moisture agent is modified polycarboxylic acid salt: acrylic acid-acrylic ester-co-polymer of sulfonate, its molecular weight 30,000, and each monomer mole ratio is acrylic acid: acrylate: sulfonic acid=1:3.2:0.8; Described thickener is that xanthans and Magnesiumaluminumsilicate are with the mixture of arbitrary proportion; Described antifreezing agent is ethylene glycol or propane diols; Described defoamer is silicone defoaming agent dimethicone, polyethers or n-octyl alcohol; Described preservative sodium benzoate; Described synergist is Cocoamidopropyl betaine.
Further, the preparation process of MTI-446 synergy suspending agent is: in the container stirred, add amount of preparation water and resistance solvent, stir, then the former medicine of dispersion moisture agent, thickener, preservative, antifreezing agent, defoamer, synergist and MTI-446 is added successively, mix, 12000 revs/min are carried out high speed shear 20-50 minute; Feed liquid after high speed shear carries out secondary sand milling, can obtain synergy MTI-446 suspending agent.
The beneficial effect adopting technique scheme to produce is: the present invention compares the MTI-446 suspending agent not adding synergist surface tension by adding synergist reduces by 8 ~ 22 mN/m.After showing to add synergist by field experiment, insecticidal effect significantly improves.The solvability of the former medicine of MTI-446 in water is large, only can make by commonsense method the aqueous suspension agent that weight content is 10% in industry, not easily make more high-load aqueous suspension agent, and the present invention is by adding resistance solvent 5# white oil, the solvability of the former medicine of MTI-446 in water is reduced greatly, solve the problem not easily preparing high-load dinotefuran aqueous suspension agent, greatly reduce the manufacturing, artificial, packaging material, cost of transportation, improve production efficiency.MTI-446 suspending agent broad-spectrum high efficacy of the present invention, safety low-poison, the crop pests such as rice fulgorid, cotten aphid and trialeurodes vaporariorum are efficient.
Embodiment
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
Add water 647 grams and 5# white oil 20 grams in the reactor having heating jacket, stir, then add dispersion moisture agent modified polycarboxylic acid salt 50 grams, thickener xanthans 2 grams, aluminium-magnesium silicate 8 grams, antifreeze glycol 50 grams, defoamer polyethers 1 gram, preservative sodium benzoate 1 gram, synergist Cocoamidopropyl betaine 20 grams and the former medicine of MTI-446 200 grams successively to mix, 12000 revs/min are carried out high speed shear 20 minutes; Then carry out secondary sand milling, can obtain 20% synergy MTI-446 suspending agent is sample one.
Embodiment 2
532 grams of water and 5# white oil 30 grams is added in the reactor having heating jacket, stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams, thickener xanthans 1 gram, aluminium-magnesium silicate 5 grams, antifreeze glycol 40 grams, defoamer n-octyl alcohol 1 gram, preservative sodium benzoate 1 gram, synergist Cocoamidopropyl betaine 30 grams and the former medicine of MTI-446 300 grams successively to mix, 12000 revs/min are carried out high speed shear 30 minutes; Then carry out secondary sand milling, can obtain 30% synergy MTI-446 suspending agent is sample two.
Embodiment 3:
307 grams of water and 5# white oil 50 grams is added in the reactor having heating jacket, stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams, thickener aluminium-magnesium silicate 0.5 gram, xanthans 0.5g, antifreezing agent propane diols 30 grams, defoamer dimethicone 1 gram, preservative sodium benzoate 1 gram, synergist Cocoamidopropyl betaine 50 grams and the former medicine of MTI-446 500 grams successively to mix, 12000 revs/min are carried out high speed shear 50 minutes; Then carry out secondary sand milling, can obtain 50% synergy MTI-446 suspending agent is sample three.
Comparative example embodiment 1
687 grams of water are added in the reactor having heating jacket, open and stir, then add dispersion moisture agent modified polycarboxylic acid salt 50 grams successively, thickener xanthans 2 grams, aluminium-magnesium silicate 8 grams, antifreeze glycol 50 grams, defoamer polyethers 1 gram, preservative sodium benzoate 1 gram, the former medicine of MTI-446 200 grams mix, 12000 revs/min are carried out high speed shear 20 minutes; Then carry out secondary sand milling, can obtain 20% MTI-446 suspending agent is sample four.
Comparative example embodiment 2
562 grams of water are added in the reactor having heating jacket, open and stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams successively, thickener xanthans 1 gram, aluminium-magnesium silicate 5 grams, antifreeze glycol 40 grams, defoamer n-octyl alcohol 1 gram, preservative sodium benzoate 1 gram, synergist water-based azone 30 grams, the former medicine of MTI-446 300 grams mix, 12000 revs/min are carried out high speed shear 30 minutes; Then carry out secondary sand milling, can obtain 30% MTI-446 suspending agent is sample five.
Comparative example embodiment 3
357 grams of water are added in the reactor having heating jacket, open and stir, then add dispersion moisture agent modified polycarboxylic acid salt 60 grams successively, thickener xanthans 0.5 gram, aluminium-magnesium silicate 0.5 gram, antifreezing agent propane diols 30 grams, defoamer dimethicone 1 gram, preservative sodium benzoate 1 gram, synergist water-based fatty alcohol 50 grams, the former medicine of MTI-446 500 grams mix, 12000 revs/min are carried out high speed shear 50 minutes; Then carry out secondary sand milling, can obtain 50% MTI-446 suspending agent is sample six.
Tensiometry Test
Surface tension size is the important indicator of preparation drug effect, and carry out Tensiometry Test to sample one ~ sample six that embodiment and comparative example embodiment configure, result of the test is as shown in table 1.
Table 1 sample one ~ sample six surface tension
| Title | Sample one | Sample two | Sample three | Sample four | Sample five | Sample six |
| Surface tension (mN/m) | 25.1 | 24.2 | 23.1 | 45.1 | 36.9 | 37.1 |
Table 1 shows, the surface tension that the MTI-446 suspending agent not adding synergist compared by the MTI-446 suspending agent adding Cocoamidopropyl betaine synergist reduces by 20 ~ 22 mN/m, adds Cocoamidopropyl betaine synergist and compares and add water-based azone and water-based fatty alcohol synergist better effects if in reduction MTI-446 suspending agent surface tension.
Land for growing field crops effect experiment one: land for growing field crops insecticidal test-cotton aphid
With sample one ~ sample six MTI-446 suspending agent in above-described embodiment 1 ~ 6, insecticidal test is carried out to Wei County, Hebei, by the drug effect of field experiment inspection MTI-446 synergy suspending agent.Specific experiment scheme is as follows:
Medication: each sample repeats twice
Extension rate: 20% MTI-446 SC 2000X 3000X other press content conversion multiple dilutions
Use apparatus: conventional backpack sprayer, directed spraying
Water consumption: every mu of 30 kg of water
Investigation method: adopt five point samplings
Control time: after medicine three, five, seven, 15 days
Revision insect recluced rate (%)=(before spray medicine, each sky remains borer population after insect population radix-spray medicine) * 100/ sprays insect population radix before medicine
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate) * 100/(100-check plot Revision insect recluced rate)
Result of the test is in table 2
Effect experiment result table 2
。
As known from Table 2, add the MTI-446 suspending agent of synergist apparently higher than not adding the MTI-446 suspending agent of synergist to cotton cotton aphid control effect, and the MTI-446 suspending agent ratio adding synergist Cocoamidopropyl betaine adds water-based azone and water-based fatty alcohol synergist control cotton cotten aphid successful strengthens.After medicine, the effect of 7 days is best
Land for growing field crops effect experiment two: land for growing field crops insecticidal test-trialeurodes vaporariorum
Trialeurodes vaporariorum on the Quzhou booth wild cabbage of Hebei creates drug resistance in various degree to most pharmaceutical agents.Insecticidal test is carried out, by the drug effect of land for growing field crops inspection MTI-446 suspending agent with above-mentioned sample one ~ sample six MTI-446 suspending agent.Specific experiment scheme is as follows:
Medication: each sample repeats twice use
Extension rate: 20% MTI-446 SC 2000X 3000X other press content conversion multiple dilutions
Use apparatus: conventional backpack sprayer, directed spraying
Water consumption: every mu of 30 kg of water
Investigation method: adopt five point samplings
Control time: after medicine three, five, seven, 15 days
Revision insect recluced rate (%)=(before spray medicine, each sky remains borer population after insect population radix-spray medicine) * 100/ sprays insect population radix before medicine
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate) * 100/(100-check plot Revision insect recluced rate)
Result of the test is as shown in table 3.
Effect experiment result table 3
。
As known from Table 3, add the MTI-446 suspending agent of synergist apparently higher than not adding the MTI-446 suspending agent of synergist to wild cabbage trialeurodes vaporariorum control efficiency, and the MTI-446 suspending agent ratio adding synergist Cocoamidopropyl betaine adds water-based azone and water-based fatty alcohol synergist control wild cabbage trialeurodes vaporariorum successful strengthens.
Land for growing field crops effect experiment three:
Carry out land for growing field crops insecticidal test with same method to Nanchang rice fulgorid, specific experiment scheme is as follows:
Medication: each sample repeats twice
Extension rate: 20% MTI-446 SC 2000X 3000X other press content conversion multiple dilutions
Use apparatus: conventional backpack sprayer, directed spraying
Water consumption: every mu of 30 kg of water
Investigation method: adopt five point samplings
Control time: after medicine three, five, seven, 15 days
Revision insect recluced rate (%)=(before spray medicine, each sky remains borer population after insect population radix-spray medicine) * 100/ sprays insect population radix before medicine
Rectifying efficacies (%)=(treatment region Revision insect recluced rate-check plot Revision insect recluced rate) * 100/(100-check plot Revision insect recluced rate)
Result of the test is as shown in table 4.
Effect experiment result table 4
。
As known from Table 4, add the MTI-446 suspending agent of synergist apparently higher than not adding the MTI-446 suspending agent of synergist to rice fulgorid control efficiency, and the MTI-446 suspending agent ratio adding synergist Cocoamidopropyl betaine adds water-based azone and water-based fatty alcohol synergist control rice fulgorid successful strengthens.
Claims (3)
1. a MTI-446 synergy suspending agent, is characterized in that it is made up of following component by weight percentage: MTI-446 20%-50%, resistance solvent 2%-5%, dispersion moisture agent 5%-8%, thickener 0.1%-1%, preservative 0.1%, antifreezing agent 3%-5%, defoamer 0.1%, synergist 2%-5%, Yu Weishui.
2. MTI-446 synergy suspending agent according to claim 1, is characterized in that described resistance solvent is 5# white oil; Described dispersion moisture agent is modified polycarboxylic acid salt: acrylic acid-acrylic ester-co-polymer of sulfonate, its molecular weight 30,000, and each monomer mole ratio is acrylic acid: acrylate: sulfonic acid=1:3.2:0.8; Described thickener is that xanthans and Magnesiumaluminumsilicate mix with arbitrary proportion; Described antifreezing agent is ethylene glycol or propane diols; Described defoamer is dimethicone, polyethers or n-octyl alcohol; Described preservative is Sodium Benzoate; Described synergist is Cocoamidopropyl betaine.
3. the preparation method of the MTI-446 synergy suspending agent described in claim 1 or 2, it is characterized in that step is as follows: in the container stirred, add amount of preparation water and resistance solvent, stir, then the former medicine of described dispersion moisture agent, thickener, preservative, antifreezing agent, defoamer, synergist and MTI-446 is added successively, mix, 12000 revs/min are carried out high speed shear 20-50 minute; Feed liquid after high speed shear carries out secondary sand milling, can obtain described MTI-446 synergy suspending agent.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108513975A (en) * | 2018-05-23 | 2018-09-11 | 河北威远生物化工有限公司 | A kind of Fluoxastrobin suspending agent and preparation method thereof for flying to prevent |
| CN109221225A (en) * | 2018-09-28 | 2019-01-18 | 绩溪农华生物科技有限公司 | A kind of dinotefuran synergy suspending agent and preparation method thereof |
| CN109258632A (en) * | 2018-09-29 | 2019-01-25 | 绩溪农华生物科技有限公司 | A kind of nano pesticide composition and preparation method thereof |
| CN115067325A (en) * | 2022-06-14 | 2022-09-20 | 江苏剑牌农化股份有限公司 | Preparation method of anhydrous dinotefuran suspending agent |
| CN115104620A (en) * | 2021-08-13 | 2022-09-27 | 山东恒利达生物科技有限公司 | Furan nicotine insecticidal composition and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102239829A (en) * | 2011-07-13 | 2011-11-16 | 南京扬子鸿利源化学品有限责任公司 | Dinotefuran aqueous suspension agent and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102239829A (en) * | 2011-07-13 | 2011-11-16 | 南京扬子鸿利源化学品有限责任公司 | Dinotefuran aqueous suspension agent and its preparation method |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108513975A (en) * | 2018-05-23 | 2018-09-11 | 河北威远生物化工有限公司 | A kind of Fluoxastrobin suspending agent and preparation method thereof for flying to prevent |
| CN109221225A (en) * | 2018-09-28 | 2019-01-18 | 绩溪农华生物科技有限公司 | A kind of dinotefuran synergy suspending agent and preparation method thereof |
| CN109258632A (en) * | 2018-09-29 | 2019-01-25 | 绩溪农华生物科技有限公司 | A kind of nano pesticide composition and preparation method thereof |
| CN115104620A (en) * | 2021-08-13 | 2022-09-27 | 山东恒利达生物科技有限公司 | Furan nicotine insecticidal composition and application thereof |
| CN115104620B (en) * | 2021-08-13 | 2023-08-11 | 山东恒利达生物科技有限公司 | Furannicotine insecticidal composition and application thereof |
| CN115067325A (en) * | 2022-06-14 | 2022-09-20 | 江苏剑牌农化股份有限公司 | Preparation method of anhydrous dinotefuran suspending agent |
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