CN103760374B - The reaction cup that a kind of chemiluminescence immune assay detects - Google Patents

Abstract

The invention provides a cuvette for chemiluminescent immunoassay detection, which comprises an integrated cup body (1), a cup edge (2) and a liquid collection tank (3), characterized in that the cup body (1) It is an inverted trapezoidal cavity shell structure, the top of the cup body (1) is provided with a rectangular opening, and the inner wall of the bottom of the cup body (1) is provided with an arc-shaped curved surface groove, and the cup edge (2) is connected to the cup The top of the body (1) extends outward parallel to the plane where the top of the cup body (1) is located, and the cup edge (2) is provided with the liquid collection groove (3). In the present invention, the bottom of the cup body (1) is an arc-shaped curved surface structure, which can reduce the generation of air bubbles when adding the reagent to be tested, and through the design of the cup edge (2), the stability of the cuvette during the transfer process is improved to avoid the need for testing reagents. The reagent overflows, and at the same time, the liquid collection tank (3) can collect part of the reagent to be tested that overflows, reducing the pollution to the instrument. The overall design of the present invention is integrated, easy to process and low in manufacturing cost.

Description

Reaction cup for chemiluminescence immunoassay detection

technical field

The invention relates to a reaction cup, in particular to a reaction cup for chemiluminescence immunoassay detection.

Background technique

In recent years, the application range of automatic tubular chemiluminescence immunoassay has become wider and wider, and it is gradually replacing semi-automatic products and plate-type enzyme-labeled products, becoming the leading product in the field of immunology. The cuvettes containing the test reagents have high requirements on light transmittance, and at the same time, when the cuvettes move under the action of the guide rails, it is easy to cause reagent overflow and contaminate the instrument. Therefore, special treatment is required for the cuvettes.

A combined cuvette disclosed in patent 200680027159.6 has the advantages of shortening the stirring time of the sample and suppressing the influence of external light sources on the measurement results. The corner is easy to cause air bubbles in the sample during stirring, which will affect the measurement results and other problems. The cuvette disclosed in patent 200710151356.5 has the advantages of preventing the liquid from overflowing inside and outside the cuvette and improving the stirring efficiency of the liquid, but it also has the disadvantage of requiring an additional mechanical device to tilt the cuvette at a certain angle to avoid the generation of air bubbles.

Contents of the invention

Aiming at the shortcomings of existing cuvettes, the present invention provides a cuvette for chemiluminescent immunoassay detection, which includes an integrated cup body 1, cup edge 2 and liquid collection tank 3, characterized in that the cup body 1 is an inverted trapezoidal cavity shell structure, the top of the cup body 1 is provided with a rectangular opening, and the inner wall of the bottom of the cup body 1 is provided with an arc-shaped curved surface groove, and the cup edge 2 is connected to the top of the cup body 1 and is parallel The plane where the top of the cup body 1 is located extends outward, and the cup rim 2 is provided with the liquid collection groove 3 .

Preferably, in the cuvette for chemiluminescence immunoassay detection, round chamfers are provided at the corners of the inner wall of the cuvette body 1 .

Preferably, in the cuvette for chemiluminescent immunoassay detection, the cross-sectional size of the inner wall of the cup body 1 decreases gradually from the top of the cup body 1 to the bottom of the cup body 1 .

Preferably, the cuvette for chemiluminescence immunoassay detection, wherein the liquid collection groove 3 is a rectangular groove.

Preferably, in the cuvette for chemiluminescent immunoassay detection, the liquid collection tank 3 is arranged parallel to the outer wall of the cuvette 1 that is close to it.

Preferably, in the cuvette for chemiluminescence immunoassay detection, there are 2 or 4 collection tanks 3 .

Preferably, in the cuvette for chemiluminescent immunoassay detection, the rim 2 of the cuvette has a rectangular structure.

Preferably, in the cuvette for chemiluminescent immunoassay detection, the wall surface of the cuvette body 1 is made of translucent material.

Preferably, in the cuvette for chemiluminescent immunoassay detection, the inner wall of the cuvette body 1 is treated with hydrophobicity.

The invention provides a cuvette for chemiluminescence immunoassay detection, which has the following advantages: 1) The inner wall of the bottom of the cup body 1 is an arc-shaped curved surface structure, which can effectively reduce the generation of air bubbles when adding the reagent to be tested; 2) The cup body 1 It is an inverted trapezoidal structure with a wide top and a narrow bottom, which can effectively prevent the reagent to be tested from overflowing during the transmission process; 3) The cup extends outward along 2, which is convenient for mechanical operation and smooth transportation of the reaction cup; 4) The design of the liquid collection tank 3 can be Collect the spilled reagent to be tested to avoid contamination of instrument components; 5) The cup body 1 adopts a symmetrical structure, and its direction can not be distinguished during optical measurement, which reduces the complexity of the measurement system and improves stability; 6) This The whole invention is an integrated design, which is easy to process and low in manufacturing cost.

Description of drawings

Fig. 1 is a side view of a cuvette for chemiluminescence immunoassay detection proposed by the present invention.

Fig. 2 is a top view of a cuvette for chemiluminescence immunoassay detection proposed by the present invention.

Detailed ways

The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

Please refer to Fig. 1, the present invention provides a cuvette for chemiluminescent immunoassay detection, which includes an integrated cup body 1, cup edge 2 and liquid collection tank 3, characterized in that the cup body 1 is an inverted trapezoid The cavity shell structure, the top of the cup body 1 is provided with a rectangular opening, and the inner wall of the bottom of the cup body 1 is provided with an arc-shaped curved surface groove, and the cup edge 2 is connected to the top of the cup body 1 and is parallel to the cup body The plane where the top of the body 1 is located extends outward, and the cup rim 2 is provided with the liquid collection groove 3 .

In the present invention,

The corners of the inner wall of the cup body 1 are provided with circular chamfers, and the cross-sectional size of the inner wall of the cup body 1 decreases gradually from the top of the cup body 1 to the bottom of the cup body 1 .

The liquid collecting tank 3 is a rectangular groove, which is arranged parallel to the outer wall of the adjacent cup body 1, and can be provided with 2 or 4 grooves.

The edge 2 of the cup is a rectangular structure.

The wall surface of the cup body 1 is made of translucent material, and the inner wall is treated with hydrophobicity.

The working process of a cuvette for chemiluminescence immunoassay detection provided by the present invention is: the edge 2 of the cuvette can use the transmission mechanism to stably transmit the cuvette to the sample adding area, the incubation area, the cleaning area, The desired location such as the measurement area. During the transfer process, since the cuvette has an inverted trapezoidal structure with a wide top and a narrow bottom, the pressure on the bottom is greater than the pressure on the upper part, which can effectively slow down the overflow of the liquid caused by the vibration of the cuvette. At the same time, the design of the cup edge 2 can To prevent the reagent to be tested from dripping onto the instrument and pollute the instrument, and the spilled reagent to be tested can be collected through the liquid collection tank 3 .

The bottom of the cup body 1 has an arc-shaped curved surface structure. When adding samples, the needle body is first placed at a slightly higher part of the bottom of the cup body 1, and then the liquid is injected out. The liquid level detection part is installed on the sample needle, and then As the liquid rises, the sample needle also rises continuously. Due to the existence of the arc surface, the impact of the liquid flow velocity can be slowed down, which greatly reduces the possibility of bubble generation, which is conducive to the accuracy of the final test result.

When the cuvette is performing optical measurement, place the cuvette in a measurement dark room, and inject the required excitation liquid into the cuvette, the substances in the cuvette start to emit light due to chemical action, and the detector is placed In the middle position close to the outside of the cuvette, since the cuvette body is translucent and symmetrical, the direction and position of the cuvette does not affect the test results, which reduces the complexity of the test system.

The width of the cup body 1 can be set according to the width between the guide rails, and the width of the cup edge 2 can be appropriately widened according to the width of the guide rails. The edge 2 of the cup can be slightly bent in an arc, and the position of the top of the liquid collection tank 3 is set to the lowest position, which is beneficial to the recovery of the overflowing reagent to be tested.

Although the embodiment of the present invention has been disclosed as above, it is not limited to the use listed in the specification and implementation, it can be applied to various fields suitable for the present invention, and it can be easily understood by those skilled in the art Therefore, the invention is not limited to the specific details and examples shown and described herein without departing from the general concept defined by the claims and their equivalents.

Claims (7)

1. A cuvette for chemiluminescent immunoassay detection, comprising an integrated cup body (1), a cup edge (2) and a liquid collection tank (3), characterized in that the cup body (1) is an inverted Trapezoidal cavity shell structure, the top of the cup body (1) is provided with a rectangular opening, and the inner wall of the bottom of the cup body (1) is provided with an arc-shaped curved surface groove, and the cup edge (2) is connected to the cup body ( 1) The top extends outward parallel to the plane where the top of the cup body (1) is located, and the cup edge (2) is provided with the sump (3), and the sump (3) is rectangular Groove, the liquid collection groove (3) is arranged parallel to the outer wall of the cup body (1) that is close to it. 2. A cuvette for chemiluminescence immunoassay detection according to claim 1, characterized in that, the inner wall corners of the cup body (1) are all provided with circular chamfers. 3. A cuvette for chemiluminescence immunoassay detection according to claim 1, characterized in that, the cross-sectional size of the inner wall of the cup body (1) is along the top of the cup body (1) toward the cup body (1) Decreasing at the bottom. 4. A cuvette for chemiluminescence immunoassay detection according to claim 1, characterized in that there are 2 or 4 collection tanks (3). 5. A cuvette for chemiluminescent immunoassay detection according to claim 1, characterized in that, the rim (2) of the cup is a rectangular structure. 6. A cuvette for chemiluminescence immunoassay detection according to claim 1, characterized in that the wall surface of the cup (1) is made of translucent material. 7. A cuvette for chemiluminescence immunoassay detection according to claim 6, characterized in that the inner wall of the cup body (1) is treated with hydrophobicity.