CN102885348A - Medlar and mulberry beverage with kidney tonifying effect and preparation method thereof - Google Patents

Abstract

The invention relates to a Qishen drink with the function of invigorating the kidney and a preparation method thereof. The beverage is prepared from raspberry, mulberry, medlar, leek seed, dodder seed, plantain seed, schisandra, epimedium, etc. It has the effects of tonifying kidney and strengthening yang, replenishing qi and consolidating essence, and is suitable for deficiency of kidney yang and loss of yin essence Crowd drinking.

Description

A kind of wolfberry beverage with kidney-tonifying effect and preparation method thereof

technical field

The invention relates to a Qishen drink with the function of invigorating the kidney and a preparation method thereof.

Background technique

Traditional Chinese medicine believes that the kidney governs the storage of essence, growth, development, reproduction, and water metabolism, and is called the "innate foundation". Kidney deficiency and essence loss can easily cause visceral dysfunction, and visceral imbalance is one of the important factors that cause diseases in the body. Therefore, tonifying the kidney and replenishing essence plays a vital role in maintaining body functions and coordinating the viscera.

Wuzi Yanzong Fang is a well-known tonifying formula. According to textual research, it was first recorded in the Taoist book "Xuanjielu". "Danxi Heart Method", "Health Prescriptions", "Criteria for Syndrome and Treatment", "Introduction to Medicine" and other books contain this prescription. The 2010 edition of "Pharmacopoeia of the People's Republic of China" also records the Chinese patent medicine preparations "Wuzi Yanzong Pill" and "Wuzi Yanzong Tablet". The whole prescription is composed of five traditional Chinese medicines: medlar, dodder, raspberry, schisandra, and plantain seed. In the prescription, medlar and dodder are used to nourish the kidney, raspberry nourishes essence, schisandra promotes body fluid, and plantain seed promotes diuresis and solidifies essence. It has obvious effects of tonifying kidney and strengthening yang Spermatogenesis, known as the "No. 1 seed" in ancient and modern times. In recent years, multidisciplinary workers have carried out in-depth discussions and researches on this ancient prescription from the aspects of clinical practice, pharmacology, and preparations. Starting from the theory of traditional Chinese medicine such as kidney governing reproduction, kidney storing essence governing bone production and marrow connecting to the brain, this prescription is used It not only confirms the theory of "different diseases are treated with the same treatment" in traditional Chinese medicine, but also contributes to revealing the essence of kidney deficiency syndrome.

On the basis of Wuzi Yanzong Fang, the present invention adds three traditional Chinese medicines of leek seed, mulberry, and epimedium, which not only greatly enhances the effect of tonifying kidney and yang, but also increases the effect of promoting body fluid and moistening dryness, strengthening muscles and bones, nourishing qi and calming heart, etc. Efficacy plays a vital role in regulating body functions and regulating viscera. According to the principles of traditional Chinese medicine "refinement of qi, qi to generate essence" and "yin and yang mutual roots", supplemented with products that nourish yin and nourish the kidney, nourish yin while nourishing yang, so as to achieve the effects of nourishing qi, strengthening the foundation, nourishing the kidney and strengthening yang. The invention has the remarkable effects of invigorating kidney and strengthening yang, replenishing qi and consolidating essence, and is suitable for drinking by people with deficiency of kidney yang and deficiency of yin essence.

Contents of the invention

The object of the present invention is to provide a Qishen drink with the effect of tonifying the kidney and its preparation method. The drink has significant effects of tonifying the kidney and strengthening yang, replenishing qi and consolidating essence, and is suitable for drinking by people with deficiency of kidney yang and deficiency of yin essence.

The present invention is achieved through the following technical solutions:

A Qishen drink with the function of invigorating the kidney is characterized in that it is prepared from the following raw materials in weight ratio: 1-25 parts of raspberry, 1-25 parts of mulberry, 1-25 parts of medlar, 1-25 parts of leek 20 parts, 1-25 parts of dodder, 1-25 parts of plantago, 1-20 parts of schisandra, 1-25 parts of epimedium. The preferred weight ratio of the present invention is: 5-15 parts of raspberry, 5-15 parts of mulberry, 5-20 parts of medlar, 3-15 parts of leek, 5-20 parts of dodder, 5-15 parts of plantago, Schisandra 3 to 15 parts, Epimedium 5 to 15 parts. The optimum weight ratio of the present invention is: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra and 10 parts of epimedium.

The Qishen beverage as described above is characterized in that the source of the raw material can be Chinese medicinal materials or extracts equivalent to the crude drug amount of Chinese medicinal materials.

The Qishen drink as described above is characterized in that Epimedium can be replaced by pilose antler, Morinda officinalis, psoralen, Yizhi, Cistanche, Cynomorium, hippocampus, Cordyceps sinensis, Eucommia, Gecko, Shayuanzi or Dipsacus any type.

The Qishen beverage as described above is characterized in that the preparation method is to weigh each raw material according to the prescription amount, add 8 to 16 times of water to soak for 0.5 hour, decoct for 1 to 3 hours, filter the medicinal liquid, and continue to add 6 to 12 times of water Decoct for 0.5-1.5 hours, filter, combine the filtrates, add sweetener, add purified water to prepare, stir evenly, filter, fill, and sterilize.

The preparation method of wolfberry fruit drink as mentioned above is characterized in that sweetener is white granulated sugar, glucose, starch syrup, maltose syrup, glucose syrup, maltitol, xylitol, erythritol, isomaltooligosaccharide, trichloro Any one or more of sucrose, aspartame, stevia, acesulfame potassium or cyclamate.

As mentioned above, the preparation method of wolfberry drink is characterized in that the finished dosage form can also be granules, tablets, capsules, soft capsules, Pills, pills or oral liquid.

As mentioned above, the preparation method of wolfberry drink is characterized in that the finished product can also be food in various forms made by conventional food preparation techniques using food acceptable excipients or food additives.

The Qishen drink as described above is characterized in that it is used in the preparation of foods for invigorating the kidney and strengthening yang, health care products or medicines.

Experimental research shows that Qishen drink has the effect of nourishing kidney and replenishing essence. The specific experiment is as follows:

1. Effect of Qishen Drink on Rats with Kidney-Yang Deficiency

1. Experimental Materials:

Sodium pentobarbital: prepared with normal saline for intraperitoneal injection, Hubei Yuancheng Gongchuang Technology Co., Ltd.;

Penicillin G Potassium: Prepared with water for injection, for intraperitoneal injection, Huabei Pharmaceutical Factory;

Animals: male SD rats, weighing 200g to 22Og, provided by the Experimental Animal Center of Jiangxi University of Traditional Chinese Medicine (permit number SCXK (江) 2009-0001);

Instrument: Pain Threshold Tester (for electrical stimulation), Dongyi (Beijing) Technology Co., Ltd.

2. experimental method:

Take 50 male rats, anesthetize them intraperitoneally with pentobarbital sodium 40 mg/kg, and after disinfecting the local skin, randomly select 10 animals as the blank control group, and remove the bilateral testicles of the remaining animals and intramuscularly inject 20,000 penicillin G potassium u/kg. On the 11th day, the castrated animals were randomly divided into model group, low-dose, middle-dose and high-dose groups of Qishen beverage, 10 animals in each group, and began to be administered continuously for 12 days. The dosage of Qishen beverage group was 1.5g, 3g, 6g of crude drug/kg, the model group and the blank control group were given the same volume of normal saline, and 1 hour after the last administration, the local penis of the animal was stimulated with a current intensity of 4mA, and the latency and duration of penile erection were observed. The animals were sacrificed the next day, and the prepuce gland, semen sac-prostate and levator ani muscle were weighed, and the organ coefficient (mg/100g) was calculated. the

3. Statistical methods

All data were statistically processed by spss11.5 statistical software, and t-test was used for comparison between groups. the

4. Experimental results

Table 1 The effect of Qishen beverage on rats with kidney yang deficiency ( ±SD)

Note: * means p<0.05 compared with the model group, ** means p<0.01 compared with the model group

The test result shows: the latent period of penile erection of animals in the low, middle and high dose groups of Qishen beverage is significantly shorter than that of the model group, the duration of erection is higher than that of the model group (P<0.01), and the organ coefficient (prepuce gland, seminal sac-prostate and levator ani muscle) were significantly higher than the model group (P<0.01), and there was a certain dose-effect relationship, showing that Qishen beverage has the effect of tonifying the kidney and replenishing essence in rats with kidney-yang deficiency.

Detailed ways

Further describe the present invention below in conjunction with example:

Example 1

The raw materials are weighed according to the following weight proportions: 2 parts of raspberry, 1 part of mulberry, 3 parts of medlar, 1 part of leek, 3 parts of dodder, 2 parts of plantago, 1 part of schisandra, and 1.5 parts of epimedium.

Preparation method: Add the above raw materials to 12 times of water and soak for 0.5 hours, decoct for 2 hours, filter the liquid medicine, continue to add 8 times of water to decoct for 1 hour, filter, combine the filtrate, add sweetener, add purified water to prepare, Stir evenly, filter, fill, and sterilize.

The above-mentioned preparation method is characterized in that the sweetener is white granulated sugar, glucose, starch syrup, maltose syrup, glucose syrup, maltitol, xylitol, erythritol, isomaltooligosaccharide, sucralose, Any one or more of spartame, stevia, acesulfame potassium or cyclamate.

The above-mentioned preparation method is characterized in that the finished dosage form can also be any dosage form made by a pharmaceutically acceptable carrier or excipient according to the conventional process of pharmacy, such as granules, tablets, capsules, soft capsules , drop pills, pills, oral liquid.

The above-mentioned preparation method is characterized in that the finished product can also be various forms of food prepared by conventional food preparation techniques using food acceptable excipients or food additives.

Example 2

The raw materials are weighed according to the following weight proportions: 22 parts of raspberry, 20 parts of mulberry, 18 parts of medlar, 12 parts of leek seed, 18 parts of dodder, 17 parts of plantago, 15 parts of schisandra, and 15 parts of epimedium.

Preparation method is the same as embodiment 1

Example 3

The raw materials are weighed according to the following weight ratio: 6 parts of raspberry, 6 parts of mulberry, 5 parts of medlar, 3 parts of leek seed, 5 parts of dodder, 6 parts of plantago, 4 parts of schisandra, and 5 parts of epimedium.

Preparation method is the same as embodiment 1

Example 4

The raw materials are weighed according to the following weight ratio: 14 parts of raspberry, 15 parts of mulberry, 17 parts of medlar, 11 parts of leek seed, 18 parts of dodder, 15 parts of plantago, 12 parts of schisandra, and 10 parts of epimedium.

Preparation method is the same as embodiment 1

Example 5

The raw materials are weighed according to the following weight proportions: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 10 parts of epimedium.

Preparation method is the same as embodiment 1

Example 6

The raw materials are weighed according to the following weight proportions: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 10 parts of antler.

Preparation method is the same as embodiment 1

Example 7

The raw materials were weighed according to the following weight ratio: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 4 parts of cordyceps.

Preparation method is the same as embodiment 1

Example 8

The raw materials were weighed according to the following weight proportions: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 7 parts of cistanche.

Preparation method is the same as embodiment 1

Example 9

The raw materials were weighed according to the following weight proportions: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 8 parts of Morinda officinalis.

Preparation method is the same as embodiment 1

Example 10

The raw materials are weighed according to the following weight ratio: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 10 parts of Eucommia.

Preparation method is the same as embodiment 1

Example 11

The raw materials were weighed according to the following weight ratio: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 10 parts of psoralen.

Preparation method is the same as embodiment 1

Example 12

The raw materials are weighed according to the following weight proportions: 10 parts of raspberry, 10 parts of mulberry, 10 parts of medlar, 6 parts of leek seed, 10 parts of dodder, 10 parts of plantago, 6 parts of schisandra, and 10 parts of schisandra.

Preparation method is the same as embodiment 1

Claims (10)

1. Qi mulberry beverage with kidney tonifying functions, it is characterized in that being prepared from by following raw material and weight proportion: 1～25 part of raspberry, 1～25 part in mulberry fruit, 1～25 part of the fruit of Chinese wolfberry, 1～20 part of semen allii tuberosi, 1～25 part of the seed of Chinese dodder, 1～25 part of plantain seed, 1～20 part in the fruit of Chinese magnoliavine, 1～25 part of barrenwort.

2. Qi mulberry beverage as claimed in claim 1, wherein the weight proportion of each raw material is: 5～15 parts of raspberries, 5～15 parts in mulberry fruit, 5～20 parts of the fruits of Chinese wolfberry, 3～15 parts of semen allii tuberosi, 5～20 parts of the seed of Chinese dodders, 5～15 parts of plantain seeds, 3～15 parts in the fruit of Chinese magnoliavine, 5～15 parts of barrenwort.

3. Qi mulberry beverage as claimed in claim 1 or 2, wherein the weight proportion of each raw material is: 10 parts of raspberries, 10 parts in mulberry fruit, 10 parts of the fruits of Chinese wolfberry, 6 parts of semen allii tuberosi, 10 parts of the seed of Chinese dodders, 10 parts of plantain seeds, 6 parts in the fruit of Chinese magnoliavine, 10 parts of barrenwort.

4. such as the described Qi mulberry of claim 1～3 beverage, the source that it is characterized in that described raw material can be Chinese medicine or the extract that is equivalent to Chinese medicine crude drug amount.

5. such as the described Qi mulberry of claim 1～3 beverage, it is characterized in that barrenwort can change any in pilose antler, Morinda officinalis, Psoralea corylifolia, intelligence development, saline cistanche, cynomorium songaricum, hippocampus, Cordyceps sinensis, the bark of eucommia, gekko, semen astragali complanati or the teasel root into.

6. such as the described Qi mulberry of claim 1～3 beverage, it is characterized in that the preparation method takes by weighing each raw material by recipe quantity, adds 8～16 times of water soakings 0.5 hour, decocted 1～3 hour, medical filtration continues to add 6～12 times of decoctings and boiled 0.5～1.5 hour, filter, merging filtrate adds sweetener, add the purified water allotment, stir, filter can, sterilization gets final product.

7. the preparation method of Qi mulberry beverage as claimed in claim 6 is characterized in that sweetener is any in white granulated sugar, glucose, starch syrup, malt syrup, glucose syrup, maltitol, xylitol, antierythrite, oligoisomaltose, Sucralose, Aspartame, stevioside, acesulfame potassium or the honey element or more than one.

8. the preparation method of Qi mulberry beverage as claimed in claim 6 is characterized in that finished dosage forms can also be granule, tablet, capsule, soft capsule, pill, pill or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by the pharmacy common process.

9. the preparation method of Qi mulberry beverage as claimed in claim 6 is characterized in that finished product can also be to adopt acceptable excipient or food additives on the food, routinely the various form food made of food preparation technology.

10. such as the described Qi mulberry of claim 1～3 beverage, it is characterized in that preparing the food of tonifying kidney and strengthening yang or the application in health products or the medicine.