CN102784299A - External use ointment for promoting wound healing without scar pigment and preparation method of external use ointment - Google Patents
External use ointment for promoting wound healing without scar pigment and preparation method of external use ointment Download PDFInfo
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Abstract
The invention relates to external use ointment for promoting wound healing without scar pigment and a preparation method of the external use ointment. The external use ointment belongs to ointment prepared from the following ingredients through being mixed in percentage by weight: 5 to 25 parts of centella extracts, 5 to 25 parts of aloe extracts, 5 to 20 parts of salviae miltiorrhizae extracts, 3 to 15 parts of polygonum cuspidatum extracts, 3 to 15 parts of dandelion extracts, 2 to 10 parts of garden burnet extracts, 5 to 20 parts of pearl powder or hydrolyzed pearl solution, 2 to 10 parts of bletilla powder, 0.5 to 3 parts of tea polyphenol powder and 700 to 950 parts of ointment base. The preparation method comprises the following steps that firstly, the extracts of centella, aloe, salviae miltiorrhizae, polygonum cuspidatum, dandelion and garden burnet are fully mixed, ethanol is used for fine extraction for 2 to 3 times, filter liquid is merged, decoloration and concentration are carried out to obtain extractum, and the temperature is lowered to 40 to 50 DEG C; then, the pearl powder or hydrolyzed pearl solution, the bletilla powder and the tea polyphenol powder are added and are mixed and stirred until the temperature is lowered to the room temperature; and finally, the mixture is fully and uniformly ground with the ointment base, and the external use ointment provided by the invention can be prepared. The external use ointment is suitable for surgical operations of burn wounds, empyrosis, beauty treatment and the like, and has the effects that the wound healing is accelerated, no scar or pigment is left, and the skin is smooth.
Description
Technical field
The present invention relates to the Chinese crude drug is the externally applied liniment that feedstock production forms, and refers to that particularly a kind of wound healing that promotes does not stay external cream of cicatrix pigment and preparation method thereof.
Background technology
In daily life, everyone reels unavoidably and produces scratch, and wherein quite a few people can stay cicatrix and pigementation in the process that wound recovers.And be directed against large-scale wound for example surgical operation, gynecilogical operation, plastic aesthetic surgery etc., and form cicatrix and pigment especially easily at the wound healing place, cause the especially youthful worry of much human.Cicatrix is a kind of natural product in the human body processes of wound repair; Damaged or skin injury leads and corium when the epidermis occurrence of large-area; When causing the epidermis of damage location not regenerate, will replace, so just form cicatrix by corium fabric cell, collagen and proliferation of vessels.Wound, infection, burn, physics or chemical damage and surgical operation etc. all can cause cicatrization and hypertrophy, and except the shallow wound of utmost point table does not form the cicatrix, remaining wound all comes to an end with scar healing.At present, the wound class externally used paste of on medical market, selling mainly plays antiinflammatory and healing effect, can effectively eliminate not seeing as yet of cicatrix and pigementation.How in accelerating wound, to make more back wound surface skin smooth and do not leave over cicatrix and pigementation, be the difficult problem that the medical research personnel attempt to solve always.
Summary of the invention
The objective of the invention is provides a kind of wound healing that promotes not stay external cream of cicatrix pigment and preparation method thereof to various operation wounds.This external cream not only has comprehensive effects such as detumescence, antipruritic, softening, regeneration, skin-active, plain, the flat cicatrix of colour killing, and its composition mainly is the pure natural health-care Chinese crude drug, has no side effect, and is safe and reliable.
For realizing above-mentioned purpose; The promotion wound healing that the present invention developed does not stay the external cream of cicatrix pigment, is to comprise that following materials of weight proportions is mixed with the unguentum that forms: Herba Centellae extract 5-25 part, Aloe extract 5-25 part, Radix Salviae Miltiorrhizae extract 5-20 part, Rhizoma Polygoni Cuspidati extract 3-15 part, Herba Taraxaci extract 3-15 part, Radix Sangusorbae extract 2-10 part, Margarita powder or Margarita hydrolyzed solution 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 2-10 part, tea polyphenol powder 0.5-3 part, ointment base 700-950 part.
Further, the preferable weight proportion of raw material is described in this external cream: Herba Centellae extract 15-25 part, Aloe extract 15-25 part, Radix Salviae Miltiorrhizae extract 8-15 part, Rhizoma Polygoni Cuspidati extract 5-10 part, Herba Taraxaci extract 5-10 part, Radix Sangusorbae extract 5-8 part, Margarita powder or Margarita hydrolyzed solution 8-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 5-8 part, tea polyphenol powder 1-2 part, ointment base 700-950 part.
As preferred version, the raw material in this external cream also comprises cutaneous permeable agent 0.05-0.1 part, antibacterial 0.1-0.5 part.
Further, above-mentioned ointment base is a kind of in Velvachol, Water-In-Oil emulsifiable paste matrix, emulsion matrix or the gel cream base matter.
Further, the preferred Oleum menthae of above-mentioned cutaneous permeable agent, the preferred hibitane of above-mentioned antibacterial, i.e. hibitane.
The present invention promotes wound healing not stay the method for preparing of the external cream of cicatrix pigment, may further comprise the steps:
1) gets Herba Centellae extract 5-25 part, Aloe extract 5-25 part, Radix Salviae Miltiorrhizae extract 5-20 part, Rhizoma Polygoni Cuspidati extract 3-15 part, Herba Taraxaci extract 3-15 part and Radix Sangusorbae extract 2-10 part by weight ratio, fully mix homogeneously;
2) use mass percentage concentration the mixture essence to be carried 2-3 time, merge each filtrate, its processing of decolouring as the ethanol of 65-95%;
3) destaining solution is condensed into the extractum shape, is cooled to 40-50 ℃, add Margarita powder or Margarita hydrolyzed solution 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 2-10 part and tea polyphenol powder 0.5-3 part more by weight ratio, mix to room temperature, obtain to contain female cream of active ingredient;
4) get ointment base 700-950 part at last by weight ratio, even with the abundant lapping-in of the female cream of gained, can be mixed with external cream of the present invention.
Further, above-mentioned steps 3) in, also add cutaneous permeable agent 0.05-0.1 part, antibacterial 0.1-0.5 part by weight ratio.
Theory of Chinese medical science thinks, the formation of cicatrix mainly is the damage of space between skin and muscles skin, and meridians are obstructed, deficiency of vital QI, and pipe is defended imbalance, and evil poison is outer goes into, and stops up the QI and blood that stagnates, and heresy is not let out row, qi depression to blood stasis, alluvial is swollen, though wound surface closes, and heresy is not let out, and is of a specified duration and condense into cicatrix.Further set forth in " prescriptions worth thousand gold " of the Tang Dynasty Sun Simiao: " the gas place is in meridians, and QI and blood is all puckery not all right, stop up become also ".Ancient Chinese medicine doctor is thought the stagnation of QI-blood that shows as at cicatrix initial stage more, invades excessive four and scurries, and has to ooze out and obvious pruritus, and this is wetly to be exposed to skin, should be with heat-clearing and toxic substances removing, and removing heat from blood and promoting blood circulation, eliminating dampness by diuresis is antipruritic to be the rule of treatment.Therefore, it is considered herein that the softening the hard mass removing food stagnancy is the rule of treatment,, improve keloid and contracture, eliminate pruritus, can reach the effect of health-care recovery in order to softening scar tissue with promoting blood circulation and breaking stagnation.
Simultaneously; The present invention is directed to the synulotic traditional Chinese medical science and discuss, furtherd investigate relevant pharmacology, the toxicity of Chinese herbal medicine, the principle of pressing the Chinese medicine monarch; Screening flavor coldest days of the year end health care Chinese herbal medicine; Through scientific combination, make it can bring into play comprehensive effect such as detumescence, antipruritic, softening, regeneration, skin-active, colour killing element, leveling scar, the mechanism of action division of its cooperative effect is following:
Herba Centellae extract
Herba Centellae is a samphire, and the dry herb of Herba Centellae is claimed Herba sambuci chinensis again, collapsed jorum, Herba Christiae Obcordatae, China as medicinal plants use existing two over thousands of years historical, be " the conventional Chinese medicine that Chinese pharmacopoeia is recorded.It has the effect of clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, and external is a carbuncle sore tumefacting virus, traumatic injury.India and other countries also are applied it as traditional medicinal plants.Herba Centellae extract is a kind of medicine of treating wound healing in Canada, and herb uses in France's approval, is used for dietary supplement in the U.S..
Herba Centellae extract (mainly containing asiatic acid and Herba Centellae Saponin), its pharmacological action have the epithelial cell of activation, promote normal granulation tissue to form, prevent effects such as adhesion generation and alleviation adhesion formation.The Madagascar area, the Medecassol that processes with the asiatic centella triterpenoid saponin composition is a kind of Wound healing agent, can promote wound healing, also can treat burn.Domestic report utilizes that Asiaticoside is for oral administration, external curing burn property cicatrix, obtains positive effect.Its mechanism of action possibly be activation malpighian stratum cell and bring out keratinization.Research shows that the Herba Centellae Saponin is stimulating the synthetic fibroblasts from hypertrophic scars I type that suppresses simultaneously of normal skin fibroblast I type to synthesize.No matter be oral, or external all can obtain better therapeutic effect.
Aloe extract
Aloe bitter in the mouth, cold in nature.Return liver, stomach, large intestine channel, have that removing heat from the liver, relieving constipation stimulate the menstrual flow, parasite killing and an antidotal effect." Bencao Jingshu " record " heat clearing away of the cold ability of Aloe, hardship can expel the heat-evil, dampness, bitter ability parasite killing is to bitter extremely cold, so be the key medicine of heat extraction parasite killing ".Aloe is a kind of ancient conventional Chinese medicine.After Han dynasty opens the Silk Road, just import Central Plains in China, bringing into play medical care effect widely for many years always, be " the formal herbal species that Chinese pharmacopoeia is recorded through Arab countries.
Aloe as medicine for external use have skin-protecting face nursing, hair caring, sun-proof, wrinkle resistant, anti-skin aging, preserve moisture, effects such as antiinflammatory, speckle dispelling.The Japan scholar finds also to contain three kinds of chemical constituents in the Aloe through the research in 8 years, A Laomi piperazine (Alomicin), Aloetin (Aloetin), Ah's Laue crow Rosin (Aloeulcin).Think that the A Laomi piperazine has remarkable antagonism to cancer; Aloetin has strong antibiotic and mycostatic nature; Can suppress growth, the breeding of pathogen antibacterial and kill them in a large number, Ah's Laue crow Rosin plays the healing effect to scald, burn, scratch and ulcer, has significant treatment wound ability.It not only has extremely strong antiinflammatory and bactericidal action, also has the effect that promotes cell metabolism and then promote tissue regeneration.
The characteristics of Aloe treatment wound are the parts that is used for wound, can not stay cicatrix basically.This is because aloetic mucin except promoting the normal cell growth, also can make lump dwindle, and accelerates repair of damaged tissues.Through promoting granulation to form decomposition with various enzymes to remove the cell and the infected tissue of death.
Radix Salviae Miltiorrhizae extract
Radix Salviae Miltiorrhizae bitter in the mouth, tepor are gone into the conscience warp.Effect with the silt of dispelling pain relieving, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire." not Lu " be carried " Radix Salviae Miltiorrhizae is specially gone into its merit of blood system and is the promoting the circulation of blood of invigorating blood circulation, and interior reaches internal organs and blood stasis dispelling stagnates, and disappears and lump in the abdomen is broken so gather, and outer profit joint and the network of promoting blood circulation, then strong the and numbness work of waist knee joint is gone ".Modern pharmacological research confirms that Radix Salviae Miltiorrhizae can promote tissue repair and regeneration.Radix Salviae Miltiorrhizae can make the fracture local stasis of blood alleviate, and local blood circulation improves, and healing time shortens.Radix Salviae Miltiorrhizae has inhibitory action for the fibrocyte of hyperplasia, so can be used for treating illness such as scleroderma, keloid.
Margarita powder (or Margarita hydrolyzed solution)
The record Margarita has the effect of " separating the pox furunculosis " in Compendium of Material Medica.Margarita powder has been widely used in the treatment of all kinds of skin injurys in the modern medical service practice, like carbuncle sore tumefacting virus, burn due to hot liquid or fire, herpes zoster and knife injury etc.With these dermatopathies of Margarita powder treatment, valuable point is the most, when wound surface recovers, all can keep the formation state of original skin, and can not precipitate by chromogenesis, does not leave over any cicatrix.
The effect of the convergence granulation promoting of Margarita powder possibly restrain the wound sepage with Margarita powder, and nutrition also stimulates wound circumference epithelial tissue hypertrophy relevant.In addition Margarita powder have remarkable prevent skin aging, smooth away wrinkles, the effect of delicate skin; And Margarita powder also has remarkable curative effect to facial speckle; This be because amino acid contained in the Margarita be the key that prevents that wrinkle of skin from occurring too early; And facial speckle is too much because of the lipid peroxide of skin, and contained manganese, copper, zinc, four kinds of trace element of selenium have good elimination effect to lipid peroxide in the Margarita.
Rhizoma Polygoni Cuspidati extract
Rhizoma Polygoni Cuspidati have dispel the wind, dampness removing, removing blood stasis with potent drugs, the effect of stimulating the menstrual flow." Guizhou side's medicine among the people collection " record Rhizoma Polygoni Cuspidati " astringing to arrest bleeding is controlled hemorrhoid complicated by anal fistula, and wind-damp dispelling is delivered cold expelling, dissipating blood stasis blood, burn is controlled in external ".The modern pharmacological research Rhizoma Polygoni Cuspidati has antibacterium, antivirus action, especially to the inhibitory action of suppurative staphylococcus aureus, bacillus pyocyaneus.Clinical report, Rhizoma Polygoni Cuspidati external can promote that wound surface heals rapidly, think that Rhizoma Polygoni Cuspidati is used for burn; Can make shrinkage type in the burn local vascular, change expanding into, increase the capillary vessel number that recovers blood flow; And can reduce platelet, erythrocyte, leukocytic aggregation, reduce thrombosis.Can make VPV quickening in the microcirculation, improve the supply of affected part oxygen and other nutrient substance, strengthen remaining epithelial cell growth and repair ability.
Herba Taraxaci extract
Herba Taraxaci has another name called Herba crotalariae albidae.Property is bitter, sweet, cold, returns liver stomach warp.Have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome effect.Herba Taraxaci can make golden yellow Portugal coccus volume expand, sclerosis, and karyon and ribosome homopolymerization integrated package, RNA interfering and DNA's is synthetic, thus the blocking-up bacterial growth shows stronger bactericidal action.The clinical various inflammation treatments such as acute mastitis, scald acne, skin furuncle and phyma that are used for.Because Folium Taraxacum contains abundant chlorophyll, healing that can accelerated in wounds.
Tea polyphenol powder
Tea polyphenols is the general name of polyhydroxyl phenolic compound contained in the Folium Camelliae sinensis, abbreviates TP (Teaupolyphenol) as, and its main component is a catechin, accounts for the 65-80% of tea polyphenols total amount.Tea polyphenols is remarkable in many-sided effects such as antioxidation, antibiotic, radioprotective, antitumor, and especially the effect of antioxidation and free radical resisting is that other common antioxidants are incomparable.Tea polyphenols has very strong oxygen delivery capacity and can be converted into inert substance with the combined with radical of skin, stops the chain reaction of free radical, fundamentally prevents and alleviates skin aging.
Ultraviolet is the main cause of skin free-radical generating, and ray can cause the fracture of interior biomolecule of body and hydrone, produces a large amount of radical damage skins.Tea polyphenols is comparatively responsive to ultraviolet, and is especially the strongest to the light wave absorption of 280-320nm, can directly stop the damaging action of ultraviolet to skin, so the laudatory title of " ultraviolet filter " is arranged.Therefore can suppress UV-induced photosensitive dermatitis, the free radical of shielding of ultraviolet and ultraviolet induction, thus reduce chromogenesis.The activity of tea polyphenols restraint of tyrosinase reduces melanic formation simultaneously, has the skin-whitening effect.
Age pigment is the generation of lipofuscin, exactly because the crosslinked biomacromolecule that contains free ammonia of lipid peroxidation product malonaldehyde, causes cell component to be destroyed and accumulate in cell, to produce.In addition, malonaldehyde can cause the crosslinked of collagen in the connective tissue, makes former albumen be cross-linked into huge insoluble molecule mutually, and makes skin wrinkle, aging occur.Because tea polyphenols has very strong oxidation resistance, the ability of its elimination activity oxygen-derived free radicals is better than V
EAnd V
CTherefore, have clearing up and discharging or alleviate the Secondary cases pigementation and effects such as chloasma, senile plaque, wrinkle.
Tea polyphenols as a kind of wide spectrum, strong imitate, the antibacterials of low toxicity are generally acknowledged by many scholars in the world.To causing the staphylococcus aureus of burn, wound pyogenic infection, Bacillus proteus, Pseudomonas aeruginosas etc. have the obvious suppression effect.
Pseudobulbus Bletillae (Rhizoma Bletillae) powder and Radix Sangusorbae extract
The Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Sanguisorbae are a pair of associating medicament commonly used on traumatism treatment.Radix Sanguisorbae has the function of removing heat from blood, convergence, hemostasis, heat clearing away, and the Pseudobulbus Bletillae (Rhizoma Bletillae) has the effect of convergence, hemostasis, detumescence and promoting granulation.Both combinations can form one deck medicine film at wound surface, the associating antibacterial action of Herba Taraxaci, Rhizoma Polygoni Cuspidati, tea polyphenols in addition, the effect that can give full play of and protect from infection, protect wound surface, promotes healing.
The invention has the advantages that: the external cream that is provided by the traditional Chinese medical science about synulotic theory; With the monarch and his subjects' four Chinese medicine thing Herba Centellae, Aloe, Radix Salviae Miltiorrhizae and the capable promoting blood circulation and breaking stagnation of Margarita powder, softening the hard mass removing food stagnancy, unimpeded venation, improve the effect of nutrition, assistant plays anti-inflammation, detumescence and promoting granulation, astringing to arrest bleeding, protection wound surface, promotes the effect of healing with Rhizoma Polygoni Cuspidati, Herba Taraxaci, Pseudobulbus Bletillae (Rhizoma Bletillae) powder, Radix Sanguisorbae, tea polyphenol powder.So have the effect that accelerating wound healing, wound surface skin are smooth, do not stay cicatrix and pigementation.
The specific embodiment
Promote wound healing not stay external cream of cicatrix pigment and preparation method thereof to do further to describe in detail below in conjunction with specific embodiment to the present invention.
Embodiment 1: the preparation of Velvachol external cream
1) gets commercially available each raw material: Herba Centellae extract 20g, Aloe extract 20g, Radix Salviae Miltiorrhizae extract 12g, Rhizoma Polygoni Cuspidati extract 8g, Herba Taraxaci extract 7g and Radix Sangusorbae extract 6g, fully mix homogeneously;
2) using mass percentage concentration is that 75% ethanol soaks mixture, carries 3 times through 70-80 ℃ of backflow essence, merges each filtrate, and it is carried out the routine processing of decolouring;
3) destaining solution is condensed into the extractum shape, is cooled to 40-50 ℃, add Margarita powder 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 6g and tea polyphenol powder 2g earlier, mix to room temperature, add Oleum menthae 0.1g, hibitane 0.3g again, continue to stir, obtain to contain female cream of active ingredient;
4) Velvachol contains 25% white vaseline, 25% octadecanol, 12% propylene glycol and 1.5% sodium lauryl sulphate by weight ratio, and surplus is a distilled water.Get this Velvachol 800g, even with the abundant lapping-in of the female cream of gained, be mixed with amber external cream, through fill, sterilization, detection, get product.
Embodiment 2: the preparation of Water-In-Oil emulsifiable paste matrix external cream
1) gets commercially available each raw material: Herba Centellae extract 25g, Aloe extract 22g, Radix Salviae Miltiorrhizae extract 8g, Rhizoma Polygoni Cuspidati extract 10g, Herba Taraxaci extract 6g and Radix Sangusorbae extract 8g, fully mix homogeneously;
2) using mass percentage concentration is that 95% ethanol soaks mixture, carries 2 times through 70-80 ℃ of backflow essence, merges each filtrate, and it is carried out the routine processing of decolouring;
3) destaining solution is condensed into the extractum shape, is cooled to 40-50 ℃, add Margarita hydrolyzed solution 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 8g and tea polyphenol powder 1g earlier; Mix to room temperature; Add Oleum menthae 0.08g, hibitane 0.5g again, continue to stir, obtain to contain female cream of active ingredient;
4) Water-In-Oil emulsifiable paste matrix (W/O emulsifiable paste matrix) contains 10% glyceryl monostearate, 10% hard paraffin, 5% white vaseline, 50% liquid Paraffin, 0.5% span by weight ratio
40With 0.5% emulsifying agent op, surplus is a distilled water.Get this Water-In-Oil emulsifiable paste matrix 700g, even with the abundant lapping-in of the female cream of gained, be mixed with amber external cream, through fill, sterilization, detection, get product.
Embodiment 3: the preparation of emulsion matrix external cream
1) gets commercially available each raw material: Herba Centellae extract 15g, Aloe extract 18g, Radix Salviae Miltiorrhizae extract 15g, Rhizoma Polygoni Cuspidati extract 5g, Herba Taraxaci extract 5g and Radix Sangusorbae extract 10g, fully mix homogeneously;
2) using mass percentage concentration is that 80% ethanol soaks mixture, carries 3 times through 70-80 ℃ of backflow essence, merges each filtrate, and it is carried out the routine processing of decolouring;
3) destaining solution is condensed into the extractum shape, is cooled to 40-50 ℃, add Margarita powder 18g, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 5g and tea polyphenol powder 1.5g earlier, mix to room temperature, add Oleum menthae 0.05g, hibitane 0.2g again, continue to stir, obtain to contain female cream of active ingredient;
4) emulsion matrix contains 1.5% stearic acid, 6% white vaseline, 1.5% hexadecanol, 0.3% olive oil, 0.5% triethanolamine, 12% liquid paraffin, 3% propylene glycol by weight ratio, and surplus is a distilled water.Get this emulsion matrix 950g, even with the abundant lapping-in of the female cream of gained, be mixed with the external cream of emulsion form, through fill, sterilization, detection, get product.
Embodiment 4: the preparation of gel cream base matter external cream
1) gets commercially available each raw material: Herba Centellae extract 10g, Aloe extract 10g, Radix Salviae Miltiorrhizae extract 15g, Rhizoma Polygoni Cuspidati extract 15g, Herba Taraxaci extract 15g and Radix Sangusorbae extract 5g, fully mix homogeneously;
2) using mass percentage concentration is that 70% ethanol soaks mixture, carries 2 times through 70-80 ℃ of backflow essence, merges each filtrate, and it is carried out the routine processing of decolouring;
3) destaining solution is condensed into the extractum shape, is cooled to 40-50 ℃, add Margarita powder 8g, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 8g and tea polyphenol powder 2g earlier, mix to room temperature, add Oleum menthae 0.1g, hibitane 0.4g again, continue to stir, obtain to contain female cream of active ingredient;
4) gel cream base matter contains 10% propylene glycol, 1.8% triethanolamine, 4% Acritamer 940 by weight ratio, and surplus is a distilled water.Get this gel cream base matter 900g, even with the abundant lapping-in of the female cream of gained, be mixed with gelatinous external cream, through fill, sterilization, detection, get product.
Claims (10)
1. external cream that promotes that wound healing does not stay the cicatrix pigment, it is characterized in that: this external cream is to comprise that following materials of weight proportions is mixed with the unguentum that forms: Herba Centellae extract 5-25 part, Aloe extract 5-25 part, Radix Salviae Miltiorrhizae extract 5-20 part, Rhizoma Polygoni Cuspidati extract 3-15 part, Herba Taraxaci extract 3-15 part, Radix Sangusorbae extract 2-10 part, Margarita powder or Margarita hydrolyzed solution 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 2-10 part, tea polyphenol powder 0.5-3 part, ointment base 700-950 part.
2. do not stay the external cream of cicatrix pigment according to the said promotion wound healing of claim 1, it is characterized in that: the weight proportion of raw material is described in this external cream: Herba Centellae extract 15-25 part, Aloe extract 15-25 part, Radix Salviae Miltiorrhizae extract 8-15 part, Rhizoma Polygoni Cuspidati extract 5-10 part, Herba Taraxaci extract 5-10 part, Radix Sangusorbae extract 5-8 part, Margarita powder or Margarita hydrolyzed solution 8-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 5-8 part, tea polyphenol powder 1-2 part, ointment base 700-950 part.
3. do not stay the external cream of cicatrix pigment according to claim 1 or 2 said promotion wound healings, it is characterized in that: the raw material in this external cream also comprises cutaneous permeable agent 0.05-0.1 part, antibacterial 0.1-0.5 part.
4. do not stay the external cream of cicatrix pigment according to claim 1 or 2 said promotion wound healings, it is characterized in that: said ointment base is a kind of in Velvachol, Water-In-Oil emulsifiable paste matrix, emulsion matrix or the gel cream base matter.
5. do not stay the external cream of cicatrix pigment according to the said promotion wound healing of claim 3, it is characterized in that: said ointment base is a kind of in Velvachol, Water-In-Oil emulsifiable paste matrix, emulsion matrix or the gel cream base matter.
6. do not stay the external cream of cicatrix pigment according to the said promotion wound healing of claim 3, it is characterized in that: said cutaneous permeable agent is an Oleum menthae, and said antibacterial is a hibitane.
7. do not stay the external cream of cicatrix pigment according to the said promotion wound healing of claim 5, it is characterized in that: said cutaneous permeable agent is an Oleum menthae, and said antibacterial is a hibitane.
8. method for preparing that promotes that wound healing does not stay the external cream of cicatrix pigment, it is characterized in that: this method may further comprise the steps:
1) gets Herba Centellae extract 5-25 part, Aloe extract 5-25 part, Radix Salviae Miltiorrhizae extract 5-20 part, Rhizoma Polygoni Cuspidati extract 3-15 part, Herba Taraxaci extract 3-15 part and Radix Sangusorbae extract 2-10 part by weight ratio, fully mix homogeneously;
2) use mass percentage concentration the mixture essence to be carried 2-3 time, merge each filtrate, its processing of decolouring as the ethanol of 65-95%;
3) destaining solution is condensed into the extractum shape, is cooled to 40-50 ℃, add Margarita powder or Margarita hydrolyzed solution 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 2-10 part and tea polyphenol powder 0.5-3 part more by weight ratio, mix to room temperature, obtain to contain female cream of active ingredient;
4) get ointment base 700-950 part at last by weight ratio, even with the abundant lapping-in of the female cream of gained, can be mixed with external cream of the present invention.
9. said according to Claim 8 promotion wound healing does not stay the method for preparing of the external cream of cicatrix pigment, it is characterized in that: in the said step 3), also add cutaneous permeable agent 0.05-0.1 part, antibacterial 0.1-0.5 part by weight ratio.
10. do not stay the method for preparing of the external cream of cicatrix pigment according to the said promotion wound healing of claim 9, it is characterized in that: said ointment base is a kind of in Velvachol, Water-In-Oil emulsifiable paste matrix, emulsion matrix or the gel cream base matter; Said cutaneous permeable agent is an Oleum menthae, and said antibacterial is a hibitane.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535679A (en) * | 2015-12-30 | 2016-05-04 | 胡广 | Probiotic enzyme ecological-restoration composition |
| CN106265484A (en) * | 2016-08-16 | 2017-01-04 | 湖南中威制药有限公司 | A kind of Oxiconazole Nitrate cream preparation and production method thereof |
| CN107115558A (en) * | 2017-04-27 | 2017-09-01 | 王天湶 | A kind of wound dressing of anti-pigment deposition and preparation method thereof |
| CN108210653A (en) * | 2016-12-10 | 2018-06-29 | 王仙 | A kind of aloe masking liquid and preparation method thereof |
| CN112691067A (en) * | 2019-10-23 | 2021-04-23 | 上海承曜生物科技有限公司 | Skin care composition rich in oriental beauty tea extract |
| JP2022549102A (en) * | 2019-11-28 | 2022-11-24 | 浙江養生堂天然薬物研究所有限公司 | Skin Topical Compositions with Effectiveness in Promoting Wound Healing and/or Scar Repair |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535679A (en) * | 2015-12-30 | 2016-05-04 | 胡广 | Probiotic enzyme ecological-restoration composition |
| CN105535679B (en) * | 2015-12-30 | 2018-08-21 | 胡广 | A kind of probiotics ferment restoration of the ecosystem composition |
| CN106265484A (en) * | 2016-08-16 | 2017-01-04 | 湖南中威制药有限公司 | A kind of Oxiconazole Nitrate cream preparation and production method thereof |
| CN108210653A (en) * | 2016-12-10 | 2018-06-29 | 王仙 | A kind of aloe masking liquid and preparation method thereof |
| CN107115558A (en) * | 2017-04-27 | 2017-09-01 | 王天湶 | A kind of wound dressing of anti-pigment deposition and preparation method thereof |
| CN112691067A (en) * | 2019-10-23 | 2021-04-23 | 上海承曜生物科技有限公司 | Skin care composition rich in oriental beauty tea extract |
| CN112691067B (en) * | 2019-10-23 | 2023-06-09 | 上海承曜生物科技有限公司 | Skin repair agent composition rich in oriental tea extract |
| JP2022549102A (en) * | 2019-11-28 | 2022-11-24 | 浙江養生堂天然薬物研究所有限公司 | Skin Topical Compositions with Effectiveness in Promoting Wound Healing and/or Scar Repair |
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