diff --git a/Python/ceval.c b/Python/ceval.c
index 324d062fe9bb43..e2521a4954d815 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -676,15 +676,6 @@ extern void _PyUOpPrint(const _PyUOpInstruction *uop);
  * so consume 3 units of C stack */
 #define PY_EVAL_C_STACK_UNITS 2
 
-#if defined(_MSC_VER) && defined(_Py_USING_PGO)
-/* gh-111786: _PyEval_EvalFrameDefault is too large to optimize for speed with
-   PGO on MSVC. Disable that optimization temporarily. If this is fixed
-   upstream, we should gate this on the version of MSVC.
- */
-#  pragma optimize("t", off)
-/* This setting is reversed below following _PyEval_EvalFrameDefault */
-#endif
-
 PyObject* _Py_HOT_FUNCTION
 _PyEval_EvalFrameDefault(PyThreadState *tstate, _PyInterpreterFrame *frame, int throwflag)
 {
@@ -1125,7 +1116,6 @@ _PyEval_EvalFrameDefault(PyThreadState *tstate, _PyInterpreterFrame *frame, int
 #  pragma GCC diagnostic pop
 #elif defined(_MSC_VER) /* MS_WINDOWS */
 #  pragma warning(pop)
-#  pragma optimize("", on)
 #endif
 
 static void