Background and objectives Studies have shown that resilient persons are better in coping with lif... more Background and objectives Studies have shown that resilient persons are better in coping with life and work events. Despite adversity they experience self-control and find the strength to carry on. We are interested in how resilience can be influenced in terms of not getting discouraged. Being aware of one’s thoughts and feelings meanwhile not becoming seized is referred to as mindfulness. Mindful persons do not judge, but rather observe and accept the situation at hand. More mindful persons will also be more resilient because mindfulness reduces stress symptoms and focuses on the here and now. Due to this focus of attention persons are better able to regain life and can better deal with setbacks. In this study we examine under which circumstances dispositional mindfulness is associated with being in a state of resilience. More specifically, we test whether a state of well-being and reflection and rumination as emotion regulation strategies moderate the relationship between mindfuln...
BackgroundFK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant ... more BackgroundFK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma.AimsTo examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype.MethodIn 401 general population twins, four functional polymorphisms were examined in models of psychosis and Cortisol, and followed up in models of psychosis in three samples at different familial liability (175 controls, 200 unaffected siblings and 195 patients with a psychotic disorder).ResultsThe most consistent finding was an interaction between childhood trauma and rs9296158/rs4713916 on psychotic symptoms and Cortisol in the twin sample, combined with a directionally similar interaction in siblings (rs4713916) and patients (rs9296158), A-allele carriers at both polymorphisms being most vulnerable to trauma.ConclusionsTrauma may increase the risk of psychosis through enduring changes in the Cortisol ...
BackgroundA bias to develop negative affect in response to daily life stressors may be an importa... more BackgroundA bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess.AimsTo assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life.MethodThe experience samping method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between daily life mood bias and DSM – IV depression were conducted.ResultsProbands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins.ConclusionsGenetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true de...
The tendency to experience negative emotions in the face of stress may lead to repeated overactiv... more The tendency to experience negative emotions in the face of stress may lead to repeated overactivation of the hypothalamic-pituitary-adrenal axis. In a sample of 556 women, this study used the Experience Sampling Method to assess different daily stressors, current mood, and salivary cortisol, 10 times daily for 5 days. Multilevel analyses estimated the contributions of stressors and mood states as predictors of salivary cortisol secretion. Results showed that minor stressors were associated with decreased positive affect and increased negative affect, agitation, and cortisol. Of the mood states, only negative affect was independently associated with cortisol. Negative affect also mediated effects of daily stressors on cortisol. Although further research is needed to clarify: (i) the causal pathways between daily stress, mood, and cortisol and (ii) the importance of daily stress reactivity as a prospective risk factor, these findings confirm that minor daily stressors can influence emotional and biological processes involved in subjective well-being.
Background and objectives Studies have shown that resilient persons are better in coping with lif... more Background and objectives Studies have shown that resilient persons are better in coping with life and work events. Despite adversity they experience self-control and find the strength to carry on. We are interested in how resilience can be influenced in terms of not getting discouraged. Being aware of one’s thoughts and feelings meanwhile not becoming seized is referred to as mindfulness. Mindful persons do not judge, but rather observe and accept the situation at hand. More mindful persons will also be more resilient because mindfulness reduces stress symptoms and focuses on the here and now. Due to this focus of attention persons are better able to regain life and can better deal with setbacks. In this study we examine under which circumstances dispositional mindfulness is associated with being in a state of resilience. More specifically, we test whether a state of well-being and reflection and rumination as emotion regulation strategies moderate the relationship between mindfuln...
BackgroundFK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant ... more BackgroundFK506 binding protein 5 (FKBP5) has repeatedly been shown to be a critical determinant of post-traumatic stress disorder (PTSD) and depression following childhood trauma.AimsTo examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype.MethodIn 401 general population twins, four functional polymorphisms were examined in models of psychosis and Cortisol, and followed up in models of psychosis in three samples at different familial liability (175 controls, 200 unaffected siblings and 195 patients with a psychotic disorder).ResultsThe most consistent finding was an interaction between childhood trauma and rs9296158/rs4713916 on psychotic symptoms and Cortisol in the twin sample, combined with a directionally similar interaction in siblings (rs4713916) and patients (rs9296158), A-allele carriers at both polymorphisms being most vulnerable to trauma.ConclusionsTrauma may increase the risk of psychosis through enduring changes in the Cortisol ...
BackgroundA bias to develop negative affect in response to daily life stressors may be an importa... more BackgroundA bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess.AimsTo assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life.MethodThe experience samping method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between daily life mood bias and DSM – IV depression were conducted.ResultsProbands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins.ConclusionsGenetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true de...
The tendency to experience negative emotions in the face of stress may lead to repeated overactiv... more The tendency to experience negative emotions in the face of stress may lead to repeated overactivation of the hypothalamic-pituitary-adrenal axis. In a sample of 556 women, this study used the Experience Sampling Method to assess different daily stressors, current mood, and salivary cortisol, 10 times daily for 5 days. Multilevel analyses estimated the contributions of stressors and mood states as predictors of salivary cortisol secretion. Results showed that minor stressors were associated with decreased positive affect and increased negative affect, agitation, and cortisol. Of the mood states, only negative affect was independently associated with cortisol. Negative affect also mediated effects of daily stressors on cortisol. Although further research is needed to clarify: (i) the causal pathways between daily stress, mood, and cortisol and (ii) the importance of daily stress reactivity as a prospective risk factor, these findings confirm that minor daily stressors can influence emotional and biological processes involved in subjective well-being.
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