Papers by William H Seiple
Investigative Ophthalmology & Visual Science, Jun 16, 2013
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Investigative Ophthalmology & Visual Science, Mar 26, 2012
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PubMed, Jun 1, 1998
Purpose: To assess the feasibility of obtaining reliable multifocal rod electroretinograms (ERGS)... more Purpose: To assess the feasibility of obtaining reliable multifocal rod electroretinograms (ERGS) and to compare them to full-field ERGs. Methods: Multifocal rod ERGs were recorded using a stimulus array of 61 hexagons. The minimum number of dark, blank frames between flashes was varied from 0 (a minimum of 13.3 msec between flashes) to 21 (a minimum of 293 msec between flashes). Full-field ERGs were obtained using trains of flashes designed to simulate the multifocal sequences. Flashes were blue (W47B), except in a few cases in which red (W26) was used to check for cone intrusion. Flash intensities varied from -1 to 1.7 log scot td-s. Results: Dark-adapted, multifocal ERGs to blue flashes had a small, early component followed by a larger, late component. The early component showed little change in amplitude with increasing intensity. Comparisons with the full-field ERGs indicated that the early component was the focal response. The larger, late component was the response to stray light, and it can be suppressed with the addition of a surround. The focal response was from a relatively circumscribed retinal region. This is shown by comparing the multifocal rod responses from a patient with retinitis pigmentosa to her behaviorally measured rod visual field. Conclusions: By choosing conditions (namely, flashes of moderate intensity with a surround) to minimize the effects of stray light, multifocal rod ERGs can be recorded with sufficient localization to be clinically useful. However, the signal-to-noise ratio of these multifocal rod ERGs was poorer than for multifocal cone responses for comparable recording periods because of the need for blank frames and the slower recovery of the rods to successive presentations.
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Human Factors, Jun 1, 1995
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Electroencephalography and Clinical Neurophysiology, Dec 1, 1989
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Investigative Ophthalmology & Visual Science, May 5, 2011
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Ophthalmic and Physiological Optics, Mar 1, 2005
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British Journal of Ophthalmology, Jun 1, 1989
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Journal of the Optical Society of America, Mar 1, 1996
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Vision Research, Jun 1, 1995
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Visual Neuroscience, Jul 1, 1994
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Optometry and Vision Science, Dec 1, 1993
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Investigative Ophthalmology & Visual Science, May 1, 2006
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Investigative Ophthalmology & Visual Science, Jun 16, 2013
Despite high prevalence of central and para-central scotomas and the success of available treatme... more Despite high prevalence of central and para-central scotomas and the success of available treatments, no precise automated means to measure the size or shape of the scotoma exists. Such information would be useful for both early detection and following treatment. Standard automated perimetry and Fundus Guided Perimetry (also known as Microperimetry) present stimuli at various intensities to obtain thresholds. The stimuli are typically in a preset grid pattern which fails to give a detailed outline of scotomas. We describe a new technique, Automated Stereocampimetry, that precisely defines the size and shape of a scotoma, and compare the results to an OCT SLO outfitted with a Fundus Guided Perimeter.
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Noninvasive Assessment of the Visual System, 1993
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Investigative Ophthalmology & Visual Science, May 1, 2004
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Investigative Ophthalmology & Visual Science, Apr 22, 2011
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Springer eBooks, 1989
The detection of small luminance differences between objects and their backgrounds is an importan... more The detection of small luminance differences between objects and their backgrounds is an important tool for navigating in the visual environment. Many visual system disorders cause patients to complain that their vision is cloudy or blurred, or that the borders of objects are blurred, even though they retain 20/20 Snellen acuity. These patients may suffer from losses in contrast sensitivity that cannot be detected using standard clinical testing. A more appropriate measure for these patients is their ability to detect small changes in luminance within a pattern. One widely used experimental measure of this ability is the contrast sensitivity function.
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Papers by William H Seiple