(Q91239723)

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IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo

scientific article published on 30 August 2018

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20 April 2020

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo (English)

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20 April 2020

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triple-negative breast cancer

1 reference

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Bramanandam Manavathi

5

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20 April 2020

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Lalita Guntuku

1

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20 April 2020

Jagadeesh Kumar Gangasani

2

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20 April 2020

Dinesh Thummuri

3

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20 April 2020

Roshan M Borkar

4

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20 April 2020

Srinivas Ragampeta

6

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20 April 2020

Jayathirtha Rao Vaidya

7

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20 April 2020

Ramakrishna Sistla

8

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20 April 2020

Naidu G M Vegi

9

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20 April 2020

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30 August 2018

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20 April 2020

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20 April 2020

38

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20 April 2020

4

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20 April 2020

581-595

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20 April 2020

Triple-negative breast cancer: an unmet medical need

1 reference

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7 January 2021

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Regulation mechanisms and signaling pathways of autophagy

1 reference

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7 January 2021

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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Role of autophagy in cancer

1 reference

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7 January 2021

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Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

The contribution of lysosomotropism to autophagy perturbation

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

A high content screening assay for identifying lysosomotropic compounds

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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Principles and current strategies for targeting autophagy for cancer treatment

1 reference

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7 January 2021

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Chloroquine and hydroxychloroquine for cancer therapy

1 reference

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7 January 2021

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A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

1 reference

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7 January 2021

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1,3,5-Triazines: A promising scaffold for anticancer drugs development

1 reference

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7 January 2021

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Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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Recent syntheses of PI3K/Akt/mTOR signaling pathway inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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Discovery of triazine-benzimidazoles as selective inhibitors of mTOR

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

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Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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Commentary. Lysosomotropic agents

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Methods in mammalian autophagy research

1 reference

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7 January 2021

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

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The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update

1 reference

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7 January 2021

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The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

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inferred from DOI database lookup

Multiple functions of BCL-2 family proteins

1 reference

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7 January 2021

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The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy is a therapeutic target in anticancer drug resistance.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Massive cell vacuolization induced by organic amines such as procainamide.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Cysteine cathepsins: multifunctional enzymes in cancer

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lysosomal involvement in cell death and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lysosomes and endoplasmic reticulum: targets for improved, selective anticancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

1 reference

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7 January 2021

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Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

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Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of macroautophagy triggers apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of autophagy by chloroquine induces apoptosis in primary effusion lymphoma in vitro and in vivo through induction of endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Lysosomal-mitochondrial cross-talk during cell death

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes

1 reference

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7 January 2021

based on heuristic

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Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy in cancer metastasis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors.

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7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy as a modulator and target in prostate cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of autophagy in cisplatin resistance in ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydroxychloroquine: from malaria to autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis of C5-tethered indolyl-3-glyoxylamide derivatives as tubulin polymerization inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FS41388-018-0446-2

7 January 2021

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Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/S41388-018-0446-2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30166591%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30166591%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

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