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Wikidata

(Q7916455)

English

vascular endothelial growth factor A

mammalian protein found in Homo sapiens

  • Vascular endothelial growth factor A
  • vascular permeability factor
  • VPF
  • VEGFA
  • vascular endothelial growth factor A121
  • vascular endothelial growth factor A165
In more languages
default values for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
8 references
retrieved
8 April 2019
stated in
MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IPI
chemoattractant activity
determination method
IDA
6 references
retrieved
5 June 2018
stated in
Expression and functions of the vascular endothelial growth factors and their receptors in human basophils
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
chemoattractant activity
determination method
IBA
IDA
6 references
retrieved
8 April 2019
stated in
Expression and functions of the vascular endothelial growth factors and their receptors in human basophils
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IBA
cell component
biological process
positive regulation of angiogenesis
determination method
IDA
IMP
6 references
retrieved
5 June 2018
stated in
Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IMP
retrieved
5 June 2018
stated in
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
positive regulation of endothelial cell proliferation
determination method
IDA
ISS
8 references
retrieved
5 June 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
ISS
retrieved
5 June 2018
stated in
Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
5 June 2018
stated in
The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692
determination method
IDA
positive regulation of endothelial cell proliferation
determination method
IBA
IDA
ISS
9 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
ISS
retrieved
8 April 2019
stated in
Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Expression and Localization of Tenomodulin, a Transmembrane Type Chondromodulin-I-Related Angiogenesis Inhibitor, in Mouse Eyes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IBA
positive regulation of angiogenesis
determination method
IBA
IDA
IMP
6 references
retrieved
8 April 2019
stated in
Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IMP
retrieved
8 April 2019
stated in
AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice
GOA
curator
UniProt
UniProt protein ID
P15692
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692
determination method
IBA

Identifiers

MeSH descriptor ID
D042461
subject named as
Vascular Endothelial Growth Factor A
0 references
RefSeq protein ID
Ensembl protein ID
Freebase ID
/m/03mc6nd
0 references
PDB structure ID
 
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