(Q73745038)

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Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus

scientific article published on 01 April 2000

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10795739%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus (English)

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6 November 2019

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R Bosselut

1

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6 November 2019

S Kubo

2

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6 November 2019

T Guinter

3

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6 November 2019

J L Kopacz

4

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6 November 2019

J D Altman

5

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6 November 2019

L Feigenbaum

6

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6 November 2019

A Singer

7

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6 November 2019

publication date

1 April 2000

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6 November 2019

1 reference

Europe PubMed Central

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6 November 2019

12

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6 November 2019

4

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Europe PubMed Central

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6 November 2019

409-418

1 reference

Europe PubMed Central

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6 November 2019

Phenotypic analysis of antigen-specific T lymphocytes

1 reference

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7 January 2021

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ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).

1 reference

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7 January 2021

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The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

1 reference

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7 January 2021

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Differential expression of CD8α and CD8β associated with MHC-restricted and non-MHC-restricted cytolytic effector cells

1 reference

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7 January 2021

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Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants.

1 reference

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7 January 2021

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Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

1 reference

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7 January 2021

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Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

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7 January 2021

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Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain

1 reference

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7 January 2021

based on heuristic

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Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice

1 reference

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7 January 2021

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Interaction between CD4 and class II MHC molecules mediates cell adhesion

1 reference

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7 January 2021

based on heuristic

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The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

1 reference

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7 January 2021

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Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1 reference

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7 January 2021

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

1 reference

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7 January 2021

based on heuristic

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CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1 reference

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7 January 2021

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Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1 reference

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7 January 2021

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A new technique for the assay of infectivity of human adenovirus 5 DNA

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7 January 2021

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Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1 reference

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7 January 2021

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Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation

1 reference

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7 January 2021

based on heuristic

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Co-engagement of CD8 with the T cell receptor is required for negative selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

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CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity

1 reference

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7 January 2021

based on heuristic

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A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection

1 reference

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7 January 2021

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The role of CD4 in T-cell activation: accessory molecule or co-receptor?

1 reference

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7 January 2021

based on heuristic

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Signals and signs for lymphocyte responses

1 reference

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7 January 2021

based on heuristic

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Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

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Helper T-cell development in the absence of CD4-p56 Ick association

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells

1 reference

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7 January 2021

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A general method for rapid site-directed mutagenesis using the polymerase chain reaction.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity

1 reference

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7 January 2021

based on heuristic

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Differential effects of zeta and eta transgenes on early alpha/beta T cell development

1 reference

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7 January 2021

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Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

1 reference

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7 January 2021

based on heuristic

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Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for CD8 beta chain in positive selection of CD8-lineage T cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A second subunit of CD8 is expressed in human T cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular biology and function of CD4 and CD8

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of TCR zeta chain in T cell development and selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

An immunological role for the CD8 beta-chain

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980193-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1074-7613(00)80193-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10795739%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10795739%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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