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Distinct roles for CD4 and CD8 as co-receptors in T cell receptor signalling
scientific article published on 01 April 1994
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
title
Distinct roles for CD4 and CD8 as co-receptors in T cell receptor signalling
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
author name string
Maroun CR
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
Julius M
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
publication date
1 April 1994
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
published in
European Journal of Immunology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
volume
24
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
issue
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
page(s)
959-966
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
cites work
Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunoregulation through CD8 (Ly-2): state of aggregation with the alpha/beta/CD3 T cell receptor controls interleukin 2-dependent T cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction between CD4 and class II MHC molecules mediates cell adhesion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct evidence for binding of CD8 to HLA class I antigens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification of rat monoclonal antibodies.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inositol trisphosphate and diacylglycerol as second messengers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The lymphocyte-specific protein tyrosine kinase p56lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Both T cell receptor (TcR)-CD3 complex and CD2 increase the tyrosine kinase activity of p56lck. CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Participation of CD4 coreceptor molecules in T-cell repertoire selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of murine CD8α is not essential for responses of T cell hybridomas to antigen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A kinase-independent function of Lck in potentiating antigen-specific T cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEJI.1830240427
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/EJI.1830240427
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
PubMed publication ID
8149965
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8149965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8149965%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 October 2019
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