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English
Structure-based rescue of common tumor-derived p53 mutants
scientific article published on 01 October 1996
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
title
Structure-based rescue of common tumor-derived p53 mutants
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
author name string
A M Wieczorek
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
J L Waterman
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
M J Waterman
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
T D Halazonetis
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
publication date
1 October 1996
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
published in
Nature Medicine
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
volume
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
issue
10
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
page(s)
1143-1146
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
cites work
p53 status and the efficacy of cancer therapy in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53: puzzle and paradigm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 mutations in human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53: a glimpse at the puppet behind the shadow play
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the specific DNA binding function of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the cryptic DNA binding function of mutant forms of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
WAF1, a potential mediator of p53 tumor suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic forms of p53 inhibit p53-regulated gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 proto-oncogene can act as a suppressor of transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis suppresses tumor growth and progression in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNM1096-1143
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NM1096-1143
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
PubMed publication ID
8837616
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8837616
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8837616%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 October 2019
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