(Q67266227)

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Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

scientific article published on February 25, 1978

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11 September 2019

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase (English)

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11 September 2019

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10.1016/S0021-9258(17)38120-6

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15 August 2023

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10.1016/S0021-9258(17)38120-6

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15 August 2023

Joseph L. Goldstein

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J L Goldstein

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11 September 2019

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M. S. Brown

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16 July 2022

J. R. Faust

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16 July 2022

I. Kaneko

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16 July 2022

A. Endo

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16 July 2022

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1 February 1978

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11 September 2019

25 February 1978

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National Center for Biotechnology Information

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=624722

16 July 2022

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http://intl.jbc.org/cgi/content/abstract/253/4/1121

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16 July 2022

https://api.elsevier.com/content/article/PII:S0021925817381206?httpAccept=text/xml

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15 August 2023

https://api.elsevier.com/content/article/PII:S0021925817381206?httpAccept=text/plain

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15 August 2023

Journal of Biological Chemistry

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11 September 2019

253

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11 September 2019

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11 September 2019

1121-1128

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:624722%20AND%20SRC:MED&resulttype=core&format=json

11 September 2019

Regulation of HMG-CoA reductase

1

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The LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism

3

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Receptor-Mediated Control of Cholesterol Metabolism

4

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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

5

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15 August 2023

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts

7

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Regulation of sterol synthesis in cultured cells by oxygenated derivatives of cholesterol

8

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Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives. Evidence supporting two distinct mechanisms.20l

10

1 reference

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15 August 2023

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

11

1 reference

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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

12

1 reference

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Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

13

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15 August 2023

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

14

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Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat

15

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Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia

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Protein measurement with the Folin phenol reagent

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Biochemistry of Polyisoprenoid Biosynthesis

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:624722%20AND%20SRC:MED&resulttype=core&format=json

11 September 2019

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