(Q57975493)

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Alexander Damalas

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Tanya Gottlieb

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Dan Michael

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Jan Taplick

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Juan Fernando Martinez Leal

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Ruth Maya

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Miri Moas

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Rony Seger

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Yoichi Taya

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Avri Ben-Ze’ev

Multiple roles of the tumor suppressor p53.

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language of work or name

English

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publication date

September 2002

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published in

Biochemical Pharmacology

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volume

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issue

5-6

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page(s)

865-871

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cites work

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The p53 and Mdm2 families in cancer.

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Genotoxic and non-genotoxic pathways of p53 induction

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Regulation and function of the p53 tumor suppressor protein

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The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

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Regulation of p53 function

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Surfing the p53 network

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Activation of p53 by oncogenes

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Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

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Excess beta-catenin promotes accumulation of transcriptionally active p53.

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Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

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Lessons from hereditary colorectal cancer

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Mutations in the APC tumour suppressor gene cause chromosomal instability

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Down-regulation of beta-catenin by activated p53.

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Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

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Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

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WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase

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Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

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Cellular survival: a play in three Akts

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Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

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p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.

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PTEN: life as a tumor suppressor

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Regulation of PTEN transcription by p53

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PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

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p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades

7 January 2021

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