(Q57272488)

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Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

scientific article published in Journal of Biological Chemistry

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Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis (English)

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Joseph A. Trapani

object named as

Joseph A. Trapani

4

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Ricky W Johnstone

object named as

Ricky W. Johnstone

2

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author name string

Kylie A. Browne

1

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David A. Jans

3

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language of work or name

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publication date

24 October 2000

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Journal of Biological Chemistry

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275

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50

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39262-39266

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Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Lymphocyte granule-mediated cell death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

CTL granules: evolution of vesicles essential for combating virus infections

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Prevention of apoptosis by a baculovirus gene during infection of insect cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Role of hydrogen peroxide in the formation of DNA adducts in HL-60 cells treated with benzene metabolites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

The role of actin-binding protein 280 in integrin-dependent mechanoprotection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Actin polymerization and intracellular solvent flow in cell surface blebbing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Actin-binding protein requirement for cortical stability and efficient locomotion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Functions of gelsolin: motility, signaling, apoptosis, cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C000622200

21 January 2018

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10.1074/JBC.C000622200

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