(Q57198378)

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Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus

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Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus (English)

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object named as

Shinsuke Taki

1

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Klaus Rajewsky

3

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author name string

Frieder Schwenk

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language of work or name

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publication date

July 1995

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European Journal of Immunology

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25

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7

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1888-1896

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Molecular analysis of V(D)J recombination

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Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

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Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.

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An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.

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Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining

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A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production.

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VH to VHDJH rearrangement is mediated by the internal VH heptamer

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Biased usage of two restricted VH gene segments in VH replacement

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Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

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10.1002/EJI.1830250715

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