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Wikidata

(Q5629167)

English

histone deacetylase 1

mammalian protein found in Homo sapiens

  • uniprot:Q13547
  • reduced potassium dependency, yeast homolog-like 1
  • HDAC1
In more languages
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No label defined

No description defined

Statements

molecular function
histone deacetylase activity
determination method or standard
IDA
IEA
IMP
TAS
7 references
retrieved
17 October 2017
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
TAS
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
TAS
retrieved
17 October 2017
stated in
Chfr is linked to tumour metastasis through the downregulation of HDAC1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IMP
retrieved
17 October 2017
stated in
The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IEA
retrieved
17 October 2017
stated in
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IDA
protein binding
determination method or standard
IPI
105 references
retrieved
8 April 2019
stated in
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chfr is linked to tumour metastasis through the downregulation of HDAC1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation of Sirt2 by p300 attenuates its deacetylase activity
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional repression of human immunodeficiency virus type 1 by AP-4
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of E2F1 function by the nuclear corepressor KAP1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Recurrent De Novo PACS2 Heterozygous Missense Variant Causes Neonatal-Onset Developmental Epileptic Encephalopathy, Facial Dysmorphism, and Cerebellar Dysgenesis.
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dnmt3L is a transcriptional repressor that recruits histone deacetylase
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
BCoR, a novel corepressor involved in BCL-6 repression
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
REST repression of neuronal genes requires components of the hSWI.SNF complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The bovine herpesvirus 1 immediate-early protein (bICP0) associates with histone deacetylase 1 to activate transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Three proteins define a class of human histone deacetylases related to yeast Hda1p
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Isolation and characterization of a novel class II histone deacetylase, HDAC10
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Deterministic direct reprogramming of somatic cells to pluripotency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dnmt3L is a transcriptional repressor that recruits histone deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Expression, purification and characterization of the human MTA2-RBBP7 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retinoblastoma protein recruits histone deacetylase to repress transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A bead-based approach for large-scale identification of in vitro kinase substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel EID family member, EID-3, inhibits differentiation and forms a homodimer or heterodimer with EID-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Prohibitin, a protein downregulated by androgens, represses androgen receptor activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
The bovine herpesvirus 1 immediate-early protein (bICP0) associates with histone deacetylase 1 to activate transcription
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
transcription factor binding
determination method or standard
IPI
TAS
5 references
retrieved
17 October 2017
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
TAS
retrieved
17 October 2017
stated in
HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
17 October 2017
stated in
INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
17 October 2017
stated in
Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
17 October 2017
stated in
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547
determination method or standard
IPI
histone deacetylase activity
determination method or standard
IBA
IDA
IEA
IMP
TAS
8 references
retrieved
8 April 2019
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
TAS
retrieved
8 April 2019
stated in
Chfr is linked to tumour metastasis through the downregulation of HDAC1
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IMP
retrieved
8 April 2019
stated in
The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IEA
retrieved
8 April 2019
stated in
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IBA
transcription factor binding
determination method or standard
IEA
IPI
TAS
6 references
retrieved
8 April 2019
stated in
Class II histone deacetylases: versatile regulators
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
TAS
retrieved
8 April 2019
stated in
Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q13547
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547
determination method or standard
IEA
cell component
biological process
physically interacts with
Gene Atlas image
PBB GE HDAC1 201209 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D056284
subject named as
Histone Deacetylase 1
0 references
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q5629167&oldid=2022908168"