(Q5514565)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

26 September 2017

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

protein binding

13 references

8 April 2019

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

The protein interaction landscape of the human CMGC kinase group

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Phosphorylation of NBR1 by GSK3 modulates protein aggregation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

protein kinase binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

protein serine/threonine kinase activity

Roles of tau protein in health and disease

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

8 April 2019

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

signaling receptor binding

1 reference

8 April 2019

Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

protein kinase A catalytic subunit binding

1 reference

8 April 2019

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

tau protein binding

1 reference

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

tau-protein kinase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

Roles of tau protein in health and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

8 April 2019

cell component

postsynapse

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

mitochondrion

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

cytoplasm

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

microtubule

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

soma

1 reference

8 April 2019

Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

apical dendrite

1 reference

8 April 2019

Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

proximal dendrite

1 reference

8 April 2019

Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of protein catabolic process

biological process

1 reference

8 April 2019

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

positive regulation of protein targeting to mitochondrion

1 reference

8 April 2019

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

chemical synaptic transmission, postsynaptic

1 reference

26 September 2017

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

negative regulation of UDP-glucose catabolic process

1 reference

8 April 2019

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

negative regulation of type B pancreatic cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

negative regulation of glycogen biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

negative regulation of glycogen synthase activity, transferring glucose-1-phosphate

1 reference

8 April 2019

Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

dopamine receptor signaling pathway

1 reference

8 April 2019

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

IRE1-mediated unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

negative regulation of glucose import

1 reference

8 April 2019

Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

negative regulation of insulin receptor signaling pathway

1 reference

8 April 2019

Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

regulation of autophagy of mitochondrion

1 reference

8 April 2019

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

negative regulation of glycogen (starch) synthase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

cellular response to insulin stimulus

1 reference

8 April 2019

Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

glycogen metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

negative regulation of signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

negative regulation of canonical Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

regulation of gene expression by genetic imprinting

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

ageing

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

insulin receptor signaling pathway

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

positive regulation of peptidyl-threonine phosphorylation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

cell migration

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

positive regulation of peptidyl-serine phosphorylation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

positive regulation of neuron apoptotic process

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

hypermethylation of CpG island

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

positive regulation of transcription by RNA polymerase II

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

cellular response to lithium ion

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

cellular response to organic cyclic compound

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

negative regulation of dendrite development

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49840&geneProductId=UniProtKB:P49840

carbohydrate metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

regulation of systemic arterial blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

cardiac left ventricle morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

insulin receptor signaling pathway

1 reference

8 April 2019

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

peptidyl-threonine phosphorylation

1 reference

8 April 2019

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of protein ubiquitination

1 reference

8 April 2019

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

negative regulation of TOR signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

cellular response to interleukin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

proteasome-mediated ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

positive regulation of heart contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

excitatory postsynaptic potential

1 reference

8 April 2019

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

negative regulation of cell growth involved in cardiac muscle cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

extrinsic apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

extrinsic apoptotic signaling pathway in absence of ligand

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

positive regulation of glycogen (starch) synthase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

positive regulation of autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49840

1 reference

8 April 2019

physically interacts with

lithium citrate

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201170

ly-2090314

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL362558

EC enzyme number

2.7.11.1

2 references

12 October 2015

http://www.uniprot.org/uniprot/P49840.txt?156

14 November 2015

http://www.uniprot.org/uniprot/P49840.txt?version=158

Gene Atlas image

PBB GE GSK3A 632 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P49840

1 reference