(Q54231898)

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Michael S Brown

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Wei-Ping Li

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Peter J Espenshade

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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language of work or name

English

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publication date

December 1999

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703-712

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cites work

1 reference

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7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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7 January 2021

Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins

1 reference

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7 January 2021

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

1 reference

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7 January 2021

Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway

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7 January 2021

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

1 reference

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7 January 2021

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

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7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

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7 January 2021

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

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7 January 2021

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

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7 January 2021

Assembly of asparagine-linked oligosaccharides

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7 January 2021

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER

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7 January 2021

A C-terminal signal prevents secretion of luminal ER proteins

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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7 January 2021

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

1 reference

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7 January 2021

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

1 reference

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7 January 2021

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

1 reference

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7 January 2021

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

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7 January 2021

The Florey Lecture, 1992. The secretion of proteins by cells

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7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

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7 January 2021

Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

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7 January 2021

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

1 reference

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7 January 2021

Brefeldin A renders Chinese hamster ovary cells insensitive to transcriptional suppression by 25-hydroxycholesterol.

1 reference

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7 January 2021

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

1 reference

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7 January 2021

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

1 reference

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7 January 2021

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

1 reference

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7 January 2021

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

1 reference

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7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

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7 January 2021

A primer on vesicle budding

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7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

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7 January 2021

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2981668-2

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

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7 January 2021