(Q52544495)

3 May 2018

title

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. (English)

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3 May 2018

author name string

Jonkers J

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3 May 2018

Meuwissen R

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3 May 2018

van der Gulden H

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3 May 2018

Peterse H

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3 May 2018

van der Valk M

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3 May 2018

Berns A

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3 May 2018

language of work or name

English

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publication date

1 December 2001

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3 May 2018

published in

Nature Genetics

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3 May 2018

volume

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3 May 2018

issue

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3 May 2018

page(s)

418-425

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3 May 2018

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium

cites work

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7 January 2021

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The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?

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Involvement of Brca2 in DNA repair

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BRCA2 is required for homology-directed repair of chromosomal breaks

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

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A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression

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The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

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The BRCA2 gene product functionally interacts with p53 and RAD51

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RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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Brca2 is required for embryonic cellular proliferation in the mouse

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

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Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

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The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

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Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice

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Conditional gene targeting

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A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

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Genetic background alters the spectrum of tumors that develop in p53-deficient mice

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Cre-mediated gene deletion in the mammary gland

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Generalized lacZ expression with the ROSA26 Cre reporter strain

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

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Cancer-susceptibility genes. Gatekeepers and caretakers

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Molecular portraits of human breast tumours

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Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription

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Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells

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Estrogens as endogenous genotoxic agents--DNA adducts and mutations

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p107 is a suppressor of retinoblastoma development in pRb-deficient mice

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Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

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Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

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The integration sites of endogenous and exogenous Moloney murine leukemia virus

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Simplified mammalian DNA isolation procedure

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Identifiers

DOI

10.1038/NG747

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3 May 2018

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3 May 2018