(Q48823384)

15 February 2018

title

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice (English)

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15 February 2018

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15 February 2018

Marcos Malumbres

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15 February 2018

Jose Luis Barbero

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Sagrario Ortega

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15 February 2018

Ignacio Prieto

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15 February 2018

Junko Odajima

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15 February 2018

Alberto Martín

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15 February 2018

Pierre Dubus

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15 February 2018

Mariano Barbacid

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15 February 2018

language of work or name

English

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publication date

17 August 2003

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15 February 2018

published in

Nature Genetics

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15 February 2018

volume

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15 February 2018

issue

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15 February 2018

page(s)

25-31

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15 February 2018

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

cites work

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7 January 2021

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1

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7 January 2021

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7 January 2021

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

1 reference

7 January 2021

Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators

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7 January 2021

Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication

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7 January 2021

Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

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7 January 2021

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

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7 January 2021

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

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7 January 2021

The mouse Mps1p-like kinase regulates centrosome duplication

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7 January 2021

Cyclin E-CDK2 is a regulator of p27Kip1.

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7 January 2021

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

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7 January 2021

Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase

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7 January 2021

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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7 January 2021

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

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7 January 2021

A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

1 reference

7 January 2021

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

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7 January 2021

Cyclin A is required at two points in the human cell cycle

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7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

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7 January 2021

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

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7 January 2021

S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells

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7 January 2021

Proliferation of cancer cells despite CDK2 inhibition.

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7 January 2021

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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7 January 2021

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

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7 January 2021

Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I.

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7 January 2021

The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes

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7 January 2021

A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes

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7 January 2021

Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity

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7 January 2021

Cyclin A1 is required for meiosis in the male mouse

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7 January 2021

Delayed early embryonic lethality following disruption of the murine cyclin A2 gene.

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7 January 2021

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

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7 January 2021

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein

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7 January 2021

The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor

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7 January 2021

Sex matters in meiosis

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7 January 2021

Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress

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7 January 2021

The mouse Spo11 gene is required for meiotic chromosome synapsis

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7 January 2021

Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog

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7 January 2021

Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis

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7 January 2021

The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility

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7 January 2021

Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing

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7 January 2021

To cycle or not to cycle: a critical decision in cancer.

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7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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7 January 2021

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

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7 January 2021

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

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7 January 2021

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

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7 January 2021

Identifiers

DOI

10.1038/NG1232

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15 February 2018

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15 February 2018