(Q48802284)

15 February 2018

title

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. (English)

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15 February 2018

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15 February 2018

Gunther Hartmann

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15 February 2018

Ulrich Kalinke

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Heinz Wiendl

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Stefan Endres

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15 February 2018

Marco Prinz

object named as

Marco Prinz

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15 February 2018

Sven G Meuth

object named as

Sven G Meuth

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15 February 2018

author name string

Angela Dann

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15 February 2018

Hendrik Poeck

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15 February 2018

Andrew L Croxford

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15 February 2018

Stefanie Gaupp

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15 February 2018

Katrin Kierdorf

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15 February 2018

Markus Knust

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15 February 2018

Dietmar Pfeifer

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15 February 2018

Cornelius Maihoefer

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15 February 2018

Klaus-Peter Knobeloch

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15 February 2018

Shizuo Akira

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15 February 2018

language of work or name

English

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publication date

4 December 2011

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15 February 2018

published in

Nature Neuroscience

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15 February 2018

volume

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15 February 2018

issue

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15 February 2018

page(s)

98-106

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15 February 2018

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

cites work

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

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Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

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Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

21 January 2018

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The roles of TLRs, RLRs and NLRs in pathogen recognition

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Pathogen recognition and innate immunity

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Activation of innate immune antiviral responses by Nod2

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The innate immune response to DNA.

21 January 2018

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Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

21 January 2018

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5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

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Activation of MDA5 requires higher-order RNA structures generated during virus infection

21 January 2018

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

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VISA is an adapter protein required for virus-triggered IFN-beta signaling

21 January 2018

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.

21 January 2018

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Shared and distinct genetic variants in type 1 diabetes and celiac disease

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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

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Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

21 January 2018

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Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

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New pieces in the puzzle: how does interferon-beta really work in multiple sclerosis?

21 January 2018

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New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS.

21 January 2018

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CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

21 January 2018

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Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS.

21 January 2018

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

21 January 2018

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Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells

21 January 2018

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

21 January 2018

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Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

21 January 2018

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Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

21 January 2018

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T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta.

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Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.

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IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages

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Functional role of type I and type II interferons in antiviral defense

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Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

21 January 2018

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

21 January 2018

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Essential role of IPS-1 in innate immune responses against RNA viruses

21 January 2018

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Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

21 January 2018

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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

21 January 2018

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12 December 2020

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation

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12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

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12 December 2020

Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia

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12 December 2020

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

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12 December 2020

Identifiers

DOI

10.1038/NN.2964

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15 February 2018

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15 February 2018