(Q48392369)

11 February 2018

title

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses (English)

1 reference

11 February 2018

excitatory amino acid antagonist

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7678966

11 August 2024

M. A. Rogawski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7678966

11 August 2024

S. D. Donevan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7678966

11 August 2024

language of work or name

English

0 references

publication date

1 January 1993

1 reference

11 February 2018

full work available at URL

https://api.elsevier.com/content/article/PII:089662739390241I?httpAccept=text/xml

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

https://api.elsevier.com/content/article/PII:089662739390241I?httpAccept=text/plain

11 August 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

11 August 2024

1 reference

11 February 2018

volume

1 reference

11 February 2018

issue

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11 February 2018

page(s)

51-59

1 reference

11 February 2018

Spider toxin blocks excitatory amino acid responses in isolated hippocampal pyramidal neurons

cites work

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

GYKI 52466 blocks the increase in extracellular glutamate induced by ischaemia.

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Glutamate neurotoxicity and diseases of the nervous system

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

A statistical test for demonstrating a presynaptic site of action for a modulator of synaptic amplitude

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system.

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

The epileptiform activity induced by 4-aminopyridine in rat amygdala slices: antagonism by non-N-methyl-D-aspartate receptor antagonists

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neurones in vivo

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Non-NMDA receptor-mediated neurotoxicity in cortical culture

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Excitatory amino acid neurotoxicity and neurodegenerative disease

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Voltage-dependent block of excitatory amino acid currents by pentobarbital

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

GYKI 52466 antagonizes glutamate responses but not NMDA and kainate responses in rat abducens motoneurones

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Kinetic analysis of interactions between kainate and AMPA: Evidence for activation of a single receptor in mouse hippocampal neurons

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Glutamate and the pathophysiology of hypoxic--ischemic brain damage

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

The non-N-methyl-D-aspartate receptor antagonists, GYKI 52466 and NBQX are anticonvulsant in two animal models of reflex epilepsy

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466.

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Glutamate receptor desensitization and its role in synaptic transmission

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors

11 August 2024

1 reference

https://api.crossref.org/works/10.1016/0896-6273(93)90241-I

11 August 2024

Identifiers

DOI

1 reference

11 February 2018

1 reference

11 February 2018