(Q48310786)

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Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.

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Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/23121022

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

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Anson Pierce

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Natalia Podlutskaya

2

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Jonathan J Halloran

3

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Stacy A Hussong

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Pei-Yi Lin

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Raquel Burbank

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Matthew J Hart

7

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

Veronica Galvan

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

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publication date

26 December 2012

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Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/23121022

Journal of Neurochemistry

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

124

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

6

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

880-893

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes

1 reference

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Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes

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Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

1 reference

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21 January 2018

Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta

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21 January 2018

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

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Automatic and quantitative measurement of protein-protein colocalization in live cells.

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FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

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HMGA1 mediates the activation of the CRYAB promoter by BRG1.

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21 January 2018

Crystallin proteins and amyloid fibrils

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21 January 2018

GRP94 in ER quality control and stress responses

1 reference

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21 January 2018

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

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21 January 2018

Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging

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Interaction of intracellular beta amyloid peptide with chaperone proteins

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Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein.

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21 January 2018

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models

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Caspase cleavage of members of the amyloid precursor family of proteins

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Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

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21 January 2018

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.

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21 January 2018

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

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21 January 2018

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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21 January 2018

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

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21 January 2018

Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress

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21 January 2018

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

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21 January 2018

Molecular chaperones in protein folding and proteostasis

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21 January 2018

mTOR signaling: at the crossroads of plasticity, memory and disease

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21 January 2018

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

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21 January 2018

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

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21 January 2018

Differential network biology

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21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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21 January 2018

Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m

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21 January 2018

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

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21 January 2018

The molecular mechanics of eukaryotic translation

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21 January 2018

Molecular mechanisms of amyloid oligomers toxicity

1 reference

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21 January 2018

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

1 reference

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21 January 2018

Repression of human heat shock factor 1 activity at control temperature by phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12080

21 January 2018

Aggresomes, inclusion bodies and protein aggregation

1 reference

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21 January 2018

Beta-synuclein exhibits chaperone activity more efficiently than alpha-synuclein

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21 January 2018

A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization.

1 reference

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21 January 2018

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

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21 January 2018

SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 zeta and BAD in H9c2 cells

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21 January 2018

Molecular mechanisms of mTOR-mediated translational control

1 reference

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21 January 2018

Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice

1 reference

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21 January 2018

Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

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Developments of a water-maze procedure for studying spatial learning in the rat

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Heat shock transcription factors and sensory placode development

1 reference

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

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Translational control during heat shock

1 reference

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A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice

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Multiple aggregates and aggresomes of C-terminal truncated human αA-crystallins in mammalian cells and protection by αB-crystallin

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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

1 reference

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21 January 2018

Expression of alpha B-crystallin in Alzheimer's disease

1 reference

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Cell biology. Stress response and aging.

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Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation

1 reference

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Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter

1 reference

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

1 reference

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21 January 2018

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

1 reference

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21 January 2018

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

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Transcriptional modulation of heat-shock protein gene expression

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PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.

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Aging as an event of proteostasis collapse

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Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

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21 January 2018

Regulation of heat shock gene transcription in neuronal cells

1 reference

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21 January 2018

Amyloid deposits: protection against toxic protein species?

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Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis

1 reference

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21 January 2018

14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules

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Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease

1 reference

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Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers

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21 January 2018

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience

1 reference

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21 January 2018

4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila

1 reference

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21 January 2018

Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

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inferred from PubMed ID database lookup

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

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inferred from PubMed ID database lookup

Using TESS to predict transcription factor binding sites in DNA sequence

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein Synthesis and the Antagonistic Pleiotropy Hypothesis of Aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

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inferred from PubMed ID database lookup

The chaperone activity of α-synuclein: Utilizing deletion mutants to map its interaction with target proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23121022

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/JNC.12080

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6762020&resulttype=core&format=json

12 May 2020

ResearchGate publication ID

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