(Q48275838)

10 February 2018

title

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice (English)

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10 February 2018

Mattson MP

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10 February 2018

author name string

Begley JG

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10 February 2018

Duan W

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10 February 2018

Chan S

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10 February 2018

Duff K

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10 February 2018

language of work or name

English

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publication date

1 March 1999

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10 February 2018

Journal of Neurochemistry

published in

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10 February 2018

volume

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10 February 2018

issue

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10 February 2018

page(s)

1030-1039

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10 February 2018

Aging, energy, and oxidative stress in neurodegenerative diseases.

cites work

1 reference

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

21 January 2018

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A potential role for apoptosis in neurodegeneration and Alzheimer's disease

21 January 2018

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Synaptic plasma membranes from rat brain synaptosomes: isolation and partial characterization.

21 January 2018

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An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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β-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease

21 January 2018

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Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells

21 January 2018

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Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

21 January 2018

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Presynaptic microtubules: organisation and assembly/disassembly.

21 January 2018

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Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

21 January 2018

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

21 January 2018

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

21 January 2018

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Amyloid, the presenilins and Alzheimer's disease

21 January 2018

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Mitochondrial regulation of store-operated calcium signaling in T lymphocytes

21 January 2018

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

21 January 2018

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Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system

21 January 2018

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Presenilins and Alzheimer's disease

21 January 2018

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Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

21 January 2018

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

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Synaptic pathology of Alzheimer's disease

21 January 2018

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Evidence for a six-transmembrane domain structure of presenilin 1.

21 January 2018

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

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Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

21 January 2018

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Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

21 January 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Evidence for synaptic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Human and rodent Alzheimer beta-amyloid peptides acquire distinct conformations in membrane-mimicking solvents

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

Mechanisms of neuronal degeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.1999.0721030.X

10.1046/J.1471-4159.1999.0721030.X

21 January 2018

Identifiers

DOI

1 reference

10 February 2018

1 reference

10 February 2018