(Q48269632)

10 February 2018

title

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase (English)

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10 February 2018

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10 February 2018

Christian Haass

series ordinal

object named as

Christian Haass

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Axel Imhof

object named as

Axel Imhof

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Stefan F Lichtenthaler

series ordinal

object named as

Stefan F Lichtenthaler

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10 February 2018

Bart De Strooper

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10 February 2018

Els Marjaux

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10 February 2018

language of work or name

English

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publication date

16 February 2007

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10 February 2018

Journal of Biological Chemistry

published in

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10 February 2018

volume

282

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10 February 2018

issue

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10 February 2018

page(s)

11982-11995

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10 February 2018

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Gamma-secretase: proteasome of the membrane?

21 January 2018

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ADAMs: key components in EGFR signalling and development

21 January 2018

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Shedding light on ADAM metalloproteinases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

21 January 2018

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Remarkable roles of proteolysis on and beyond the cell surface

21 January 2018

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Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

ADAMs family members as amyloid precursor protein alpha-secretases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

21 January 2018

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Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

The pervasiveness of interleukin-1 in alzheimer pathogenesis: a role for specific polymorphisms in disease risk

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Interleukin-1, neuroinflammation, and Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Soluble interleukin-1 receptor type II levels are elevated in cerebrospinal fluid in Alzheimer's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Role of Metalloproteases in the Release of the IL-1 type II Decoy Receptor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700356200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Expression cloning screen for modifiers of amyloid precursor protein shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

The membrane form of the type II IL-1 receptor accounts for inhibitory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Membrane protein secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

A non-amyloidogenic function of BACE-2 in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M700356200

21 January 2018

Identifiers

DOI

10.1074/JBC.M700356200

1 reference

10 February 2018

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10 February 2018