(Q48021761)

7 February 2018

review article

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title

Role of binding proteins to IRS-1 in insulin signalling (English)

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7 February 2018

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W Ogawa

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7 February 2018

T Matozaki

series ordinal

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7 February 2018

M Kasuga

series ordinal

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7 February 2018

publication date

1 May 1998

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7 February 2018

Molecular and Cellular Biochemistry

published in

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7 February 2018

volume

182

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7 February 2018

issue

1-2

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7 February 2018

page(s)

13-22

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7 February 2018

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1

cites work

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12 December 2020

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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12 December 2020

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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12 December 2020

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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12 December 2020

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

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12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

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12 December 2020

Pleckstrin domain homology

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12 December 2020

Binding of G protein beta gamma-subunits to pleckstrin homology domains

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12 December 2020

Mechanism of activation of protein kinase B by insulin and IGF-1

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12 December 2020

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

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12 December 2020

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

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12 December 2020

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

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12 December 2020

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase

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12 December 2020

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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12 December 2020

Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras

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12 December 2020

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

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12 December 2020

Association of insulin receptor substrate-1 with integrins

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12 December 2020

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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12 December 2020

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

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12 December 2020

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.

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12 December 2020

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

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12 December 2020

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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12 December 2020

Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells

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12 December 2020

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

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12 December 2020

Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase

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12 December 2020

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

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12 December 2020

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

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12 December 2020

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

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12 December 2020

The PH domain: a common piece in the structural patchwork of signalling proteins

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12 December 2020

The insulin signaling system

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12 December 2020

Insulin signal transduction and the IRS proteins

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12 December 2020

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

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12 December 2020

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

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12 December 2020

A signal chain of events

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12 December 2020

Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin

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12 December 2020

Characterization of a 115-kDa protein that binds to SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in Chinese hamster ovary cells

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12 December 2020

Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes

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12 December 2020

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

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12 December 2020

The insulin-sensitive glucose transporter

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12 December 2020

The insulin receptor: structure, function, and signaling

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12 December 2020

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

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12 December 2020

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

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12 December 2020

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

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12 December 2020

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells

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12 December 2020

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

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12 December 2020

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

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12 December 2020

Phosphoinositide kinases

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12 December 2020

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase

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12 December 2020

Association of insulin receptor substrate 1 with simian virus 40 large T antigen

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12 December 2020

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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12 December 2020

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.

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12 December 2020

Requirement for the adapter protein GRB2 in EGF receptor endocytosis

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12 December 2020

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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12 December 2020

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction

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12 December 2020

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

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12 December 2020

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C

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12 December 2020

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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12 December 2020

A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways

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12 December 2020

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction

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12 December 2020

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

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12 December 2020

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

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12 December 2020

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

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12 December 2020

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

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12 December 2020

The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase

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12 December 2020

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

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12 December 2020

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

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12 December 2020

SH2/SH3 signaling proteins

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12 December 2020

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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12 December 2020

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

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12 December 2020

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

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12 December 2020

Characterization of a 60-kilodalton substrate of the insulin receptor kinase

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12 December 2020

Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

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12 December 2020

Normal Activation of P70 S6 Kinase by Insulin in Cells Overexpressing Dominant Negative 85-kDa Subunit of Phosphoinositide 3-Kinase

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12 December 2020

The role of ras proteins in insulin signal transduction

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12 December 2020

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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12 December 2020

PI 3-kinase: structural and functional analysis of intersubunit interactions

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12 December 2020

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

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12 December 2020

Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling

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12 December 2020

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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12 December 2020

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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12 December 2020

Regulation of gene expression by insulin

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12 December 2020

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

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12 December 2020

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

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12 December 2020

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

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12 December 2020

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

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12 December 2020

The IRS-1 signaling system

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12 December 2020

Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1

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12 December 2020

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

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12 December 2020

Expression of a Catalytically Inert SYP Blocks Activation of Map Kinase Pathway Downstream of P21ras

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12 December 2020

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

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12 December 2020

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

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12 December 2020

Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion.

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12 December 2020

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

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12 December 2020

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

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12 December 2020

The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes

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12 December 2020

Csk enhances insulin-stimulated dephosphorylation of focal adhesion proteins

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12 December 2020

Role of IRS-2 in insulin and cytokine signalling

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12 December 2020

Roles of protein-tyrosine phosphatases in growth factor signalling

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12 December 2020

Regulation of protein synthesis by insulin

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12 December 2020

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

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12 December 2020

Role of IRS-1-GRB-2 complexes in insulin signaling

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12 December 2020

A putative modular domain present in diverse signaling proteins

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12 December 2020

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

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12 December 2020

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

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12 December 2020

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor

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12 December 2020

Small GTP-binding proteins and the regulation of the actin cytoskeleton

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12 December 2020

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

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12 December 2020

Identifiers

DOI

10.1023/A:1006862807598

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7 February 2018

Dimensions Publication ID

1039855845

0 references

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7 February 2018