(Q47830185)

6 February 2018

review article

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title

Inhibition of amyloid formation: a strategy to delay the onset of Alzheimer's disease. (English)

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6 February 2018

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Lansbury PT Jr

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6 February 2018

publication date

1 August 1997

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6 February 2018

Current Opinion in Chemical Biology

published in

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6 February 2018

volume

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6 February 2018

issue

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6 February 2018

page(s)

260-267

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6 February 2018

Alzheimer's disease: genotypes, phenotypes, and treatments

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7 January 2021

Strategies to alter the progression of Alzheimer's disease

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7 January 2021

Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

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7 January 2021

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

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7 January 2021

Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

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7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype.

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

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7 January 2021

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

A strategy for designing inhibitors of beta-amyloid toxicity

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

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https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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7 January 2021

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7 January 2021

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Insertion of lysosomal targeting sequences to the amyloid precursor protein reduces secretion of beta A4.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

A beta deposition inhibitor screen using synthetic amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Expression of apolipoprotein E inhibits aggregation of the C-terminal fragments of beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Concentration-dependent inhibitory effects of apolipoprotein E on Alzheimer's beta-amyloid fibril formation in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

Effectiveness of anthracycline against experimental prion disease in Syrian hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2897%2980018-X

7 January 2021

10.1016/S1367-5931(97)80018-X

Identifiers

DOI

1 reference

6 February 2018

1 reference

6 February 2018