(Q47624762)

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Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity

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Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity (English)

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Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

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based on heuristic

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Raymond Chuen-Chung Chang

4

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Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

5

object named as

Jacques Hugon

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Europe PubMed Central

PubMed publication ID

4 February 2018

object named as

Kwok-Fai So

3

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2

object named as

Man-Shan Yu

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

1

object named as

Ka-Chun Suen

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

language of work or name

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publication date

15 September 2003

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Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

number of pages

9

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

278

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Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

50

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

49819-49827

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

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Mechanisms of neuronal degeneration in Alzheimer's disease

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21 January 2018

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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21 January 2018

Amyloid beta peptide induces necrosis rather than apoptosis

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21 January 2018

Apoptosis and the nervous system

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Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

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Caspases: intracellular signaling by proteolysis

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Caspases: enemies within

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Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

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Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

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Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

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Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology

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Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons

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Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

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Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration

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21 January 2018

PKR; a sentinel kinase for cellular stress

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21 January 2018

PACT, a protein activator of the interferon-induced protein kinase, PKR.

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Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

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Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR

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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

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RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

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21 January 2018

PKR, apoptosis and cancer

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The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors.

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21 January 2018

Caspase 9 activation by the dsRNA-dependent protein kinase, PKR: molecular mechanism and relevance.

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BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis

1 reference

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21 January 2018

Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

1 reference

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21 January 2018

Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2α

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21 January 2018

Caspase-mediated cleavage of the Ca2+/calmodulin-dependent protein kinase-like kinase facilitates neuronal apoptosis

1 reference

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Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor

1 reference

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21 January 2018

Fas and Fas Ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death

1 reference

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21 January 2018

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

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21 January 2018

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

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21 January 2018

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

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The cause of neuronal degeneration in Alzheimer's disease

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Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

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21 January 2018

Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases

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21 January 2018

Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects

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Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

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Caspases: the executioners of apoptosis

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Caspase structure, proteolytic substrates, and function during apoptotic cell death

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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

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21 January 2018

Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

1 reference

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21 January 2018

Evaluation of beta-amyloid peptide 25-35 on calcium homeostasis in cultured rat dorsal root ganglion neurons

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Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide

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Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system

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Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation

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Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity

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Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases

1 reference

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21 January 2018

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

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21 January 2018

Confirmation by FRET in individual living cells of the absence of significant amyloid beta -mediated caspase 8 activation

1 reference

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21 January 2018

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M306503200

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/12975376

ResearchGate publication ID

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