(Q46125131)

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PKR, a cognitive decline biomarker, can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients

scientific article published on 4 February 2009

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scholarly article

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

PKR, a cognitive decline biomarker, can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients (English)

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

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6

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Jacques Hugon

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Europe PubMed Central

PubMed publication ID

19 December 2017

author name string

Milena Damjanac

1

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Guylène Page

2

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Stéphanie Ragot

3

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Guillaume Laborie

4

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Roger Gil

5

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Marc Paccalin

7

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

publication date

4 February 2009

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Journal of Cellular and Molecular Medicine

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

13

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

8B

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

1823-1832

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease

1 reference

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Oxidative stress and transcriptional regulation in Alzheimer disease

1 reference

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Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death

1 reference

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21 January 2018

Distinct destructive signal pathways of neuronal death in Alzheimer's disease

1 reference

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21 January 2018

The double-stranded RNA-dependent protein kinase PKR: structure and function

1 reference

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21 January 2018

PKR; a sentinel kinase for cellular stress

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PKR activation in neurodegenerative disease

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21 January 2018

An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease

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21 January 2018

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

1 reference

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21 January 2018

Targets and mechanisms for the regulation of translation in malignant transformation

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21 January 2018

The target of rapamycin (TOR) proteins

1 reference

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21 January 2018

Ribosomal S6 kinase signaling and the control of translation

1 reference

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21 January 2018

Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease

1 reference

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21 January 2018

Peripheral p70S6k levels and emotional memory in patients with Alzheimer's disease

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21 January 2018

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

1 reference

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21 January 2018

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Regulation of mTOR and cell growth in response to energy stress by REDD1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Platelet amyloid precursor protein processing: a bio-marker for Alzheimer's disease

1 reference

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21 January 2018

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

1 reference

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21 January 2018

Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Hippocampal Myc and p53 expression following transient global ischemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Apoptotic gene expression in Alzheimer's disease hippocampal tissue.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Changes of p53 in the brains of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1582-4934.2009.00688.X

21 January 2018

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

1 reference

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21 January 2018

The complexity of p53 stabilization and activation

1 reference

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Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.

1 reference

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Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

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Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint

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p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

1 reference

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21 January 2018

Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals.

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T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease.

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Growth control under stress: mTOR regulation through the REDD1-TSC pathway

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Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway

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Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

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Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

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The coordinate regulation of the p53 and mTOR pathways in cells

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Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity

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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

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Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease

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Impact of Aging: Sporadic, and Genetic Risk Factors on Vulnerability to Apoptosis in Alzheimer's Disease

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19210572

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1 reference

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1 reference

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1 reference

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10.1111/J.1582-4934.2009.00688.X

1 reference

Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

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https://api.fatcat.wiki/v0/release/fhefp6zizrezdjguokxyisyzoe

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Europe PubMed Central

PMC publication ID

2 July 2019

http://europepmc.org/abstract/PMC/6529964

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Europe PubMed Central

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2 July 2019

http://europepmc.org/abstract/PMC/6529964

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