(Q44529190)

English

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

scientific article published on 28 July 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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Christine Van Broeckhoven

6

object named as

Christine Van Broeckhoven

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Bart De Strooper

10

object named as

Bart De Strooper

1 reference

Europe PubMed Central

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3 December 2017

author name string

Omar Nyabi

1

1 reference

Europe PubMed Central

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3 December 2017

Mostafa Bentahir

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Katrien Horré

3

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

An Herreman

4

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Numa Gottardi-Littell

5

1 reference

Europe PubMed Central

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3 December 2017

Pascal Merchiers

7

1 reference

Europe PubMed Central

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3 December 2017

Kurt Spittaels

8

1 reference

Europe PubMed Central

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3 December 2017

Wim Annaert

9

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Europe PubMed Central

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3 December 2017

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publication date

28 July 2003

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Europe PubMed Central

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3 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

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3 December 2017

278

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Europe PubMed Central

PubMed publication ID

3 December 2017

44

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Europe PubMed Central

PubMed publication ID

3 December 2017

43430-43436

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

A cell biological perspective on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilins and the intramembrane proteolysis of proteins: facts and fiction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Recombinant adenovirus is an appropriate vector for endocytotic protein trafficking studies in cultured neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Arrayed adenoviral expression libraries for functional screening

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilins are processed by caspase-type proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Aggresomes: a cellular response to misfolded proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306957200

21 January 2018

Identifiers

10.1074/JBC.M306957200

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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