(Q44374511)

2 December 2017

title

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells (English)

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2 December 2017

Bert Vogelstein

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2 December 2017

Prasad V Jallepalli

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2 December 2017

Christoph Lengauer

series ordinal

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2 December 2017

Fred Bunz

series ordinal

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2 December 2017

language of work or name

English

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publication date

24 March 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

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2 December 2017

page(s)

20475-20479

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2 December 2017

cites work

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

CHK2 kinase--a busy messenger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

The INK4a/ARF network in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Analysis of CHK2 in vulval neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Securin is required for chromosomal stability in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Characterization of tumor-associated Chk2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

RAF/RAS oncogenes and mismatch-repair status

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Concomitant inactivation of p53 and Chk2 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

Screening hCHK2 for Mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M213159200

21 January 2018

Identifiers

DOI

10.1074/JBC.M213159200

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2 December 2017

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