(Q44292825)

1 December 2017

title

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein (English)

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1 December 2017

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1 December 2017

Baur AS

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1 December 2017

publication date

1 June 2001

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Trends in Biochemical Sciences

1 December 2017

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inferred from page(s)

published in

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1 December 2017

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1 December 2017

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1 December 2017

page(s)

356-363

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Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

1 December 2017

cites work

1 reference

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7 January 2021

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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7 January 2021

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

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7 January 2021

The numerous effector functions of Nef.

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7 January 2021

Interactions of HIV-1 NEF with cellular signal transducing proteins

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7 January 2021

HIV: a new role for Nef in the spread of HIV.

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7 January 2021

The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

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7 January 2021

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

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7 January 2021

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

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7 January 2021

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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7 January 2021

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

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7 January 2021

HIV-1 auxiliary proteins: making connections in a dying cell

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7 January 2021

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

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7 January 2021

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

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7 January 2021

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

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7 January 2021

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

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7 January 2021

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

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7 January 2021

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

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7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

1 reference

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7 January 2021

Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.

1 reference

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7 January 2021

The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism.

1 reference

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7 January 2021

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

1 reference

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7 January 2021

Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

1 reference

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7 January 2021

Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein

1 reference

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7 January 2021

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

1 reference

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7 January 2021

Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity.

1 reference

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7 January 2021

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

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7 January 2021

NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro

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7 January 2021

Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 Tax protein is through cooperation of NF-kappaB and Tat.

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7 January 2021

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

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7 January 2021

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

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7 January 2021

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0004%2801%2901846-1

7 January 2021

10.1016/S0968-0004(01)01846-1

Identifiers

DOI

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1 December 2017

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