(Q43626708)

25 November 2017

title

The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis (English)

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25 November 2017

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Lauber K

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25 November 2017

Appel HA

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25 November 2017

Schlosser SF

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25 November 2017

Gregor M

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25 November 2017

Schulze-Osthoff K

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25 November 2017

Wesselborg S

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25 November 2017

language of work or name

English

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publication date

31 May 2001

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Journal of Biological Chemistry

25 November 2017

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inferred from page(s)

published in

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25 November 2017

volume

276

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25 November 2017

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25 November 2017

page(s)

29772-29781

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Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

25 November 2017

cites work

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

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Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

21 January 2018

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Apoptosis signaling by death receptors.

21 January 2018

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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The Bcl-2 protein family: arbiters of cell survival

21 January 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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21 January 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

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Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

21 January 2018

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

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WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

21 January 2018

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

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Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

21 January 2018

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

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Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

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Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

21 January 2018

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Caspase activation: the induced-proximity model

21 January 2018

1 reference

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Caspase-9 and APAF-1 form an active holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspase-9 can be activated without proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

21 January 2018

1 reference

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

21 January 2018

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

21 January 2018

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Oncogene-dependent apoptosis is mediated by caspase-9.

21 January 2018

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Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis

21 January 2018

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

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The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

21 January 2018

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Serial killers: ordering caspase activation events in apoptosis

21 January 2018

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Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

21 January 2018

1 reference

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Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Insights into programmed cell death through structural biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspases: their intracellular localization and translocation during apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspases disrupt the nuclear-cytoplasmic barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M101524200

21 January 2018

Identifiers

DOI

10.1074/JBC.M101524200

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25 November 2017

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