(Q43556620)

24 November 2017

title

Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation (English)

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24 November 2017

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24 November 2017

Waelde CA

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24 November 2017

Xiang X

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24 November 2017

Rana A

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24 November 2017

Wen R

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24 November 2017

Luo Z

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24 November 2017

language of work or name

English

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publication date

26 March 2001

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Journal of Biological Chemistry

24 November 2017

published in

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24 November 2017

volume

276

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24 November 2017

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24 November 2017

page(s)

25157-25165

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Raf meets Ras: completing the framework of a signal transduction pathway

24 November 2017

cites work

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14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

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Mutational activation of c-raf-1 and definition of the minimal transforming sequence

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

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Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

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The effector interactions of p21ras

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An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

21 January 2018

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Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line

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Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

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Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

21 January 2018

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14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

21 January 2018

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

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Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

21 January 2018

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Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

21 January 2018

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

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21 January 2018

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Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

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A role for Pak protein kinases in Schwann cell transformation

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Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

21 January 2018

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

21 January 2018

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Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

21 January 2018

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Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

21 January 2018

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Substrates enhance autophosphorylation and activation of p21-activated protein kinase gamma-PAK in the absence of activation loop phosphorylation

21 January 2018

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Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking

21 January 2018

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Microtubules and signal transduction

21 January 2018

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Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

21 January 2018

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21 January 2018

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Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

21 January 2018

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Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

21 January 2018

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14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain

21 January 2018

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The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

21 January 2018

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Autoregulation of the Raf-1 serine/threonine kinase

21 January 2018

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Identification of residues in the cysteine-rich domain of Raf-1 that control Ras binding and Raf-1 activity

21 January 2018

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The making of a bomb scientist

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M100152200

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24 November 2017

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