(Q43507724)

English

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

scientific article published in January 2001

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Europe PubMed Central

PubMed publication ID

24 November 2017

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Alzheimer's disease

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phosphorylation

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based on heuristic

inferred from title

4

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Europe PubMed Central

PubMed publication ID

24 November 2017

Matthieu Garnier

object named as

M Garnier

2

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7

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P Greengard

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Europe PubMed Central

PubMed publication ID

24 November 2017

Eva-Maria Mandelkow

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object named as

E M Mandelkow

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Europe PubMed Central

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24 November 2017

author name string

S Leclerc

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Europe PubMed Central

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24 November 2017

R Hoessel

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24 November 2017

J A Bibb

5

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Europe PubMed Central

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24 November 2017

G L Snyder

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Europe PubMed Central

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24 November 2017

J Biernat

8

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Europe PubMed Central

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24 November 2017

Y Z Wu

9

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Europe PubMed Central

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24 November 2017

G Eisenbrand

11

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24 November 2017

L Meijer

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24 November 2017

language of work or name

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publication date

1 January 2001

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Europe PubMed Central

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24 November 2017

Journal of Biological Chemistry

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24 November 2017

276

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24 November 2017

1

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24 November 2017

251-260

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24 November 2017

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity

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Proteolysis by presenilins and the renaissance of tau.

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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

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Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

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Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

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Identifiers

10.1074/JBC.M002466200

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

ResearchGate publication ID

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