(Q42982609)

English

Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics

scientific article published on June 1996

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scholarly article

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Europe PubMed Central

PMC publication ID

12 November 2017

Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics (English)

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

author name string

S K Sreedharan

1

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

C Verma

2

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

L S Caves

3

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

S M Brocklehurst

4

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

S E Gharbia

5

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

H N Shah

6

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

K Brocklehurst

7

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

language of work or name

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publication date

1 June 1996

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Europe PubMed Central

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12 November 2017

Biochemical Journal

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Europe PubMed Central

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12 November 2017

316 ( Pt 3)

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Europe PubMed Central

PMC publication ID

12 November 2017

777-786

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

The determination of enzyme inhibitor constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Relocating a negative charge in the binding pocket of trypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Molecular dynamics simulations and rigid body (TLS) analysis of aspartate carbamoyltransferase: evidence for an uncoupled R state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Combination plots as graphical tools in the study of enzyme inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Crystal structure of a papain-E-64 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Crystal structure of bovine beta-trypsin at 1.5 A resolution in a crystal form with low molecular packing density. Active site geometry, ion pairs and solvent structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Cysteinyl proteinases and their selective inactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Substrate specificity of trypsin investigated by using a genetic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

22 Diffusion-controlled enzymatic reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Crystal structure of an actinidin-E-64 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Molecular dynamics studies of a DNA‐binding protein: 2. An evaluation of implicit and explicit solvent models for the molecular dynamics simulation of the Escherichia coli trp repressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Binding of chloromethyl ketone substrate analogues to crystalline papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Five sepharose-bound ligands for the chromatographic purification of Clostridium collagenase and clostripain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Comparative Kinetic Properties of alpha, beta and Psi Forms of Trypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1217418

26 May 2018

Electrical potentials in trypsin isozymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformational sampling using high-temperature molecular dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of gingivain, a cysteine proteinase from Porphyromonas gingivalis strain W83

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular dynamics simulation of papain-E-64 (N-[N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl]agmatine) complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional evidence for the cysteine proteinase nature of gingivain the extracellular proteinase of Porphyromonas gingivalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

trans-epoxysuccinyl-L-leucylamido (4-guanidino)-butane (E-64) inhibits trypsin-catalysed hydrolysis possibly by binding in the S1-subsite

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STUDIES ON THE ACTIVE CENTER OF TRYPSIN. THE BINDING OF AMIDINES AND GUANIDINES AS MODELS OF THE SUBSTRATE SIDE CHAIN

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromatography of trypsin and its derivatives. Characterization of a new active form of bovine trypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolutionary Similarities between Pancreatic Proteolytic Enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pseudotrypsin. A modified bovine trypsin produced by limited autodigestion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity and mechanism of clostripain catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8670152

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ3160777

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 November 2017

ResearchGate publication ID

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