(Q42796341)

7 November 2017

title

Cell-active dual specificity phosphatase inhibitors identified by high-content screening (English)

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7 November 2017

John S Lazo

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7 November 2017

Peter Wipf

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7 November 2017

Andreas Vogt

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7 November 2017

Marni Brisson

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7 November 2017

Kathleen A Cooley

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7 November 2017

Michael G Tarpley

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7 November 2017

publication date

1 August 2003

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7 November 2017

published in

Chemistry and Biology

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7 November 2017

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7 November 2017

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7 November 2017

page(s)

733-742

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Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

7 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases

1 reference

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7 January 2021

Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A

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7 January 2021

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

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7 January 2021

Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition

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7 January 2021

Dual-specificity phosphatases as targets for antineoplastic agents

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7 January 2021

CDC25 phosphatases as potential human oncogenes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma

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7 January 2021

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

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7 January 2021

Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors

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7 January 2021

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B

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7 January 2021

Evolution of anticancer drug discovery and the role of cell-based screening

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7 January 2021

Cell-based assays for identification of novel double-strand break-inducing agents

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7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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7 January 2021

Myoseverin, a microtubule-binding molecule with novel cellular effects

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7 January 2021

Real-time molecular and cellular analysis: the new frontier of drug discovery

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7 January 2021

Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway

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7 January 2021

From form to function: signaling by protein tyrosine phosphatases.

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7 January 2021

Action potential-induced quantal secretion of catecholamines from rat adrenal chromaffin cells

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7 January 2021

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation

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7 January 2021

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

Growth inhibition of hepatoma cells induced by vitamin K and its analogs.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2803%2900170-4

7 January 2021

10.1016/S1074-5521(03)00170-4

Identifiers

DOI

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7 November 2017

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