(Q42516528)

1 November 2017

title

Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome (English)

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1 November 2017

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Hans van Bokhoven

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1 November 2017

Tjitske Kleefstra

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1 November 2017

Monique C M Balemans

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1 November 2017

Nael Nadif Kasri

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1 November 2017

Maksym V Kopanitsa

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1 November 2017

Nurudeen O Afinowi

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1 November 2017

Ger Ramakers

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1 November 2017

Theo A Peters

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1 November 2017

Andy J Beynon

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1 November 2017

Sanne M Janssen

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1 November 2017

Rik C J van Summeren

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1 November 2017

Jorine M Eeftens

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1 November 2017

Nathalie Eikelenboom

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1 November 2017

Marco Benevento

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1 November 2017

Makoto Tachibana

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1 November 2017

Yoichi Shinkai

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1 November 2017

Catharina E E M Van der Zee

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1 November 2017

publication date

21 November 2012

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1 November 2017

published in

Human Molecular Genetics

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1 November 2017

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1 November 2017

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1 November 2017

page(s)

852-866

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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

1 November 2017

cites work

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Global effects of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

The chromosome 9q subtelomere deletion syndrome

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Disruption of an EHMT1-associated chromatin-modification module causes intellectual disability

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Genetic and epigenetic defects in mental retardation.

21 January 2018

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Epigenetics in the mature mammalian brain: effects on behavior and synaptic transmission

21 January 2018

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Disruption of the epigenetic code: an emerging mechanism in mental retardation

21 January 2018

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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Further clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Behavioral phenotype in the 9q subtelomeric deletion syndrome: a report about two adult patients

21 January 2018

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Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex

21 January 2018

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Epigenetic regulation of learning and memory by Drosophila EHMT/G9a

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Specific long-lasting potentiation of synaptic transmission in hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Long-lasting facilitation of a synaptic potential following tetanization in thein vitro hippocampal slice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Brain mechanisms of extinction of the classically conditioned eyeblink response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Emotional perseveration: an update on prefrontal-amygdala interactions in fear extinction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Contextual and temporal modulation of extinction: behavioral and biological mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Performance of different mouse strains in an object recognition task

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Qualitatively different modes of perirhinal-hippocampal engagement when rats explore novel vs. familiar objects as revealed by c-Fos imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Spatial memory, recognition memory, and the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

When is the hippocampus involved in recognition memory?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Mutations causing syndromic autism define an axis of synaptic pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Dendritic anomalies in disorders associated with mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Fragile X mental retardation protein in learning-related synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Genetic and epigenetic networks in intellectual disabilities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Emerging major synaptic signaling pathways involved in intellectual disability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

New life in an old idea: the synaptic plasticity and memory hypothesis revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Animal models of neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Criteria for validating mouse models of psychiatric diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Neuronal circuits of fear extinction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Histone methylation regulates memory formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

HDAC1 regulates fear extinction in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Abnormal fear conditioning and amygdala processing in an animal model of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Importance of early environment in the development of post-traumatic stress disorder-like behaviors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

A behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Anxiety in children and adolescents with autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Difference in anxiety and sensitization of the acoustic startle response between the two inbred mouse strains BALB/cAN and DBA/2N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Anxiety responses, plasma corticosterone and central monoamine variations elicited by stressors in reactive and nonreactive mice and their reciprocal F1 hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Sensory processing and stereotypical and repetitive behaviour in children with autism and intellectual disability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Differential regulation of spontaneous and evoked neurotransmitter release at central synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Short-term synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Differing presynaptic contributions to LTP and associative learning in behaving mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS490

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS490

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1 November 2017

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