(Q42061736)

15 October 2017

title

Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity (English)

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15 October 2017

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Szabó K

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15 October 2017

Bakos E

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15 October 2017

Welker E

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15 October 2017

Müller M

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15 October 2017

Goodfellow HR

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15 October 2017

Higgins CF

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15 October 2017

Váradi A

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15 October 2017

Sarkadi B

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15 October 2017

language of work or name

English

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publication date

1 September 1997

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Journal of Biological Chemistry

15 October 2017

published in

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15 October 2017

volume

272

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15 October 2017

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15 October 2017

page(s)

23165-23171

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Biochemistry of multidrug resistance mediated by the multidrug transporter

15 October 2017

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Modulation of drug permeability in chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins

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Effects of phosphorylation of P-glycoprotein on multidrug resistance

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Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance.

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Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells.

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Reversal of vinblastine resistance by a new staurosporine derivative, NA-382, in P388/ADR cells

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Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein

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Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells

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Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein

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Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites

21 January 2018

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

21 January 2018

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Drug-stimulated ATPase activity of the human P-glycoprotein

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ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells

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The catalytic cycle of P-glycoprotein

21 January 2018

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Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

21 January 2018

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Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter

21 January 2018

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Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

21 January 2018

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Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies

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Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system

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21 January 2018

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The effects of lipids and detergents on ATPase-active P-glycoprotein

21 January 2018

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Characterization and functional reconstitution of the multidrug transporter

21 January 2018

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Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

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Calcein accumulation as a fluorometric functional assay of the multidrug transporter

21 January 2018

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A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells

21 January 2018

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Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

21 January 2018

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Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

21 January 2018

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Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells

21 January 2018

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The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate

21 January 2018

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P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

21 January 2018

1 reference

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Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators

21 January 2018

1 reference

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Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.37.23165

21 January 2018

Identifiers

DOI

10.1074/JBC.272.37.23165

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15 October 2017

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